沈亚领 收藏
( 任职于 生物工程学院鲁华生物技术研究所)
生物工程专业：博士生导师/硕士生导师 生物化工专业：博士生导师 生物工程领域：工程硕士导师 沈亚领，男，工学博士，生物反应器工程国家重点实验室和生物工程学院教授，长期从事生物工程科学领域的研究工作。承担和完成国家级、省部级及横向课题项目20多项；与企业合作研发获临床批件5件；在相关学科领域发表论文100多篇，其中Sci论文... 详细>>
- Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30被引量：125收藏
- 作者：Zhang, Liaoyuan Yang, Yunlong Sun, Jian'an Shen, Yaling Wei, Dongzhi Zhu, Jiawen Chu, Ju
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2010
- 关键词：2,3-Butanediol Serratia marcescens H30 Respiratory quotient Medium optimization Fed-batch
- 质疑
- Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase被引量：96收藏
- 作者：Sun, Jian-An Zhang, Liao-Yuan Rao, Ben Shen, Ya-Ling Wei, Dong-Zhi
- 机构：E China Univ Sci & Technol;Fujian Agr & Forestry Univ
- 来源：BIORESOURCE TECHNOLOGY 2012
- 关键词：Acetoin 2,3-Butanediol Serratia marcescens Cofactor engineering Fermentation
- 质疑
- Antimetastatic effect of prodigiosin through inhibition of tumor invasion被引量：90收藏
- 作者：Zhang, J Shen, YL Liu, JW Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL PHARMACOLOGY 2005
- 关键词：prodigiosin metastasis invasion MMPs RhoA
- 质疑
- Microbial production of 2,3-butanediol by a surfactant (serrawettin)-deficient mutant of Serratia marcescens H30被引量：87收藏
- 作者：Zhang, Liaoyuan Sun, Jian'an Hao, Yingli Zhu, Jiawen Chu, Ju Wei, Dongzhi Shen, Yaling
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2010
- 关键词：2,3-Butanediol Serrawettin W1 synthase Inactivation Serratia marcescens Fed-batch
- 质疑
- Chromosomal integration of the Vitreoscilla hemoglobin gene and its physiological actions in Tremella fuciformis被引量：53收藏
- 作者：Zhu, Hu Wang, Tian-Wen Sun, Shu-Jing Shen, Ya-Ling Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering; Mycological Research Center
- 来源：Applied Microbiology and Biotechnology 2006
- 关键词：Assays - Cells - Chromosomes - DNA - Enzymes - Escherichia coli - Fermentation - Hemoglobin - Oxygen - Reaction kinetics
- 质疑
- Characterization and regulation of the 2,3-butanediol pathway in Serratia marcescens被引量：47收藏
- 作者：Rao, Ben Zhang, Liao Yuan Sun, Jian'an Su, Gang Wei, Dongzhi Chu, Ju Zhu, Jiawen Shen, Yaling
- 机构：E China Univ Sci & Technol;Fujian Agr & Forestry Univ;E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2012
- 关键词：Serratia marcescens Acetoin 2,3-Butanediol Regulation
- 质疑
- Strategy for the improvement of prodigiosin production by a Serratia marcescens mutant through fed-batch fermentation被引量：45收藏
- 作者：Tao, JL Wang, XD Shen, YL Wei, DZ
- 机构：E China Univ Sci & Technol
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2005
- 关键词：feeding strategy mutation prodigiosin Serratia marcescens ultra violet
- 质疑
- 辅酶Q_(10)的生产及在医学领域中的应用被引量：43收藏
- 作者：张继忠 迟莉丽 沈亚领
- 机构：上海医药学校;山东中医药大学附属医院;华东理工大学生物化学研究所
- 来源：《上海应用技术学院学报（自然科学版）》 2004
- 关键词：辅酶Q10 临床应用 生产方法
- 摘要：辅酶Q10是一种线粒体氧化还原酶的辅酶。目前辅酶Q10的主要应用领域是心血管病临床方面。其疗效主要是改善心肌能量产生,具有抗经活性和使生物稳定的特性。辅酶Q10具有增强体外循环中红细胞膜及免疫功能的作用、体外循环抗氧化能...
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- A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30被引量：43收藏
- 作者：Zhang, Liaoyuan Xu, Quanming Zhan, Senran Li, Yongyu Lin, Hui Sun, Shujing Sha, Li Hu, Kaihui Guan, Xiong Shen, Yaling
- 机构：Fujian Agr & Forestry Univ;E China Univ Sci & Technol;Fujian Agr & Forestry Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2014
- 关键词：Serratia marcescens Meso-2,3-butanediol dehydrogenase Cloning Expression Enzymatic properties
- 质疑
- Development of an adsorption procedure for the direct separation and purification of prodigiosin from culture broth被引量：42收藏
- 作者：Wang, XD Tao, JL Wei, DZ Shen, YL Tong, WY
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY 2004
- 关键词：adsorption resin chromatography fermentation in situ separation prodigiosin Serratia marcescens
- 质疑
- Enhanced acetoin production by serratia marcescens H32 using statistical optimization and a two-stage agitation speed control strategy被引量：42收藏
- 作者：Sun, Jianan Zhang, Liaoyuan Rao, Ben Han, Yunbin Chu, Ju Zhu, Jiawen Shen, Yaling Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering; School of Life Science; Chemical Engineering Research Center
- 来源：Biotechnology and Bioprocess Engineering 2012
- 关键词：Bottles - Speed - Speed control - Productivity
- 质疑
- Refolding and structural characteristic of TRAIL/Apo2L inclusion bodies from different specific growth rates of recombinant Escherichia coli被引量：40收藏
- 作者：Kang, Hui Sun, Ai-You Shen, Ya-Ling Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology Progress 2007
- 关键词：Fluorescence - Proteins - Scanning electron microscopy - Spectroscopy - Urea
- 质疑
- Mn2+ modulates the expression of cellulase genes in Trichoderma reesei Rut-C30 via calcium signaling被引量：39收藏
- 作者：Chen, Yumeng Shen, Yaling Wang, Wei Wei, Dongzhi
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2018
- 关键词：Trichoderma reesei Mn2+ stimulation Cellulase Mn2+ transport Calcium signaling TPMR1
- 质疑
- Extraction of Acetoin from Fermentation Broth Using an Acetone/Phosphate Aqueous Two-Phase System被引量：39收藏
- 作者：Sun, Jianan Rao, Ben Zhang, Liaoyuan Shen, Yaling Wei, Dongzhi
- 机构：E China Univ Sci & Technol;FuJian Agr & Forestry Univ
- 来源：CHEMICAL ENGINEERING COMMUNICATIONS 2012
- 关键词：Acetoin Acetone/phosphate Aqueous-two phase system Fermentation Partition coefficient Recovery
- 质疑
- Curcumin-Loaded Blood-Stable Polymeric Micelles for Enhancing Therapeutic Effect on Erythroleukemia被引量：38收藏
- 作者：Gong, Feirong Chen, Dan Teng, Xin Ge, Junhua Ning, Xianfeng Shen, Ya-ling Li, Jian Wang, Shanfeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Qingdao Univ;Univ Tennessee
- 来源：MOLECULAR PHARMACEUTICS 2017
- 关键词：curcumin polymer micelles blood-stable antitumor
- 质疑
- Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)-2,3-butanediol production被引量：36收藏
- 作者：Bai, Fangmin Dai, Lu Fan, Jiying Ngoctu Truong Rao, Ben Zhang, Liaoyuan Shen, Yaling
- 机构：E China Univ Sci & Technol;Fujian Agr & Forestry Univ
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2015
- 关键词：(3R)-acetoin (2R, 3R)-2,3-butanediol Meso-2,3-butanediol dehydrogenase (2R,3R)-2,3-butanediol dehydrogenase Serratia marcescens
- 质疑
- Enhanced acetoin production by Serratia marcescens H32 using statistical optimization and a two-stage agitation speed control strategy被引量：35收藏
- 作者：Sun, Jianan Zhang, Liaoyuan Rao, Ben Han, Yunbin Chu, Ju Zhu, Jiawen Shen, Yaling Wei, Dongzhi
- 机构：E China Univ Sci & Technol;Fujian Agr & Forestry Univ;E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2012
- 关键词：acetoin Serratia marcescens medium optimization two-stage agitation speed control strategy fed-batch fermentation
- 质疑
- Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin被引量：35收藏
- 作者：Xu, Quanming Xie, Linxiang Li, Yongyu Lin, Hui Sun, Shujing Guan, Xiong Hu, Kaihui Shen, Yaling Zhang, Liaoyuan
- 机构：Fujian Agr & Forestry Univ;E China Univ Sci & Technol;Fujian Agr & Forestry Univ
- 来源：JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY 2015
- 关键词：(3R)-acetoin Escherichia coli metabolic engineering medium optimization fed-batch
- 质疑
- In vitro-in silico screening strategy and mechanism of angiotensin I-converting enzyme inhibitory peptides from α-lactalbumin被引量：33收藏
- 作者：Xie, Dewei Du, Lei Lin, Haisheng Su, Erzheng Shen, Yaling Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Guangdong Ocean Univ;Nanjing Forestry Univ;Shanghai Collaborat Innovat Ctr Biomfg SCICB
- 来源：LWT-FOOD SCIENCE AND TECHNOLOGY 2022
- 关键词：ACE inhibitory peptide Alpha-lactalbumin Molecular docking Structure-activity relation Inhibitory mechanism
- 质疑
- The effects of angiotensin I-converting enzyme inhibitory peptide VGINYW and the hydrolysate of α-lactalbumin on blood pressure, oxidative stress and gut microbiota of spontaneously hypertensive rats被引量：32收藏
- 作者：Xie, Dewei Shen, Yaling Su, Erzheng Du, Lei Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Nanjing Forestry Univ;Shanghai Collaborat Innovat Ctr Biomfg SCICB
- 来源：FOOD & FUNCTION 2022
- 质疑
- Advances in the role and mechanism of lactic acid bacteria in treating obesity被引量：30收藏
- 作者：Shen, Yi-Lin Zhang, Liu-Qing Yang, Ying Yin, Bin-Cheng Ye, Bang-Ce Zhou, Ying
- 机构：East China Univ Sci & Technol
- 来源：FOOD BIOENGINEERING 2022
- 关键词：antiobesity GABA lactic acid bacteria mechanism SCFAs
- 质疑
- Anti-Hyperuricemic, Nephroprotective, and Gut Microbiota Regulative Effects of Separated Hydrolysate of α-Lactalbumin on Potassium Oxonate- and Hypoxanthine-Induced Hyperuricemic Mice被引量：30收藏
- 作者：Xie, Dewei Shen, Yaling Su, Erzheng Du, Lei Xie, Jingli Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Nanjing Forestry Univ;Shanghai Collaborat Innovat Ctr Biomfg SCICB
- 来源：MOLECULAR NUTRITION & FOOD RESEARCH 2023
- 关键词：anti-hyperuricemia gut microbiota hydrolysate nephroprotection alactalbumin
- 质疑
- Optimization of culture on the overproduction of TRAIL in high-cell-density culture by recombinant Escherichia coli被引量：29收藏
- 作者：Luo, Qingping Shen, Ya-Ling Wei, Dong-Zhi Cao, Wei
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2006
- 质疑
- 1,3-Propanediol production by a newly isolated strain, Clostridium perfringens GYL被引量：29收藏
- 作者：Guo, Yali Dai, Lu Xin, Bo Tao, Fei Tang, Hongzhi Shen, Yaling Xu, Ping
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2017
- 关键词：1,3-Propanediol Anaerobic Clostridium Fermentation
- 质疑
- Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidase被引量：29收藏
- 作者：Sun, Jian-An Zhang, Liao-Yuan Rao, Ben Shen, Ya-Ling Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering; School of Life Science
- 来源：Bioresource Technology 2012
- 关键词：Batch cell culture - Gene encoding
- 质疑
- High-level production of soluble tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in high-density cultivation of recombinant Escherichia coli using a combined feeding strategy被引量：29收藏
- 作者：Shen, YL Zhang, Y Sun, AY Xia, XX Wei, DZ Yang, SL
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2004
- 关键词：combined feeding strategy Escherichia coli fed-batch high-cell-density cultivation TRAIL
- 质疑
- Optimizing the medium compositions for accumulation of the novel FR-008/Candicidin derivatives CS101 by a mutant of Streptomyces sp. using statistical experimental methods被引量：28收藏
- 作者：Mao, Xiangzhao Shen, Yaling Yang, Liang Chen, Shi Yang, Yuping Yang, Jingya Zhu, Hu Deng, Zixin Wei, Dongzhi
- 机构： State Key Laboratory of Bioreactor Engineering; Laboratory of Microbial Metabolism; Department of Mathematics; College of Food Science
- 来源：Process Biochemistry 2007
- 关键词：Antibiotics - Concentration (process) - Derivatives - Mathematical models - Optimization - Statistical methods
- 质疑
- Microbial production of 2,3-butanediol by a mutagenized strain of Serratia marcescens H30被引量：28收藏
- 作者：Zhang, Liaoyuan Yang, Yunlong Sun, Jian'an Shen, Yaling Wei, Dongzhi Zhu, Jiawen Chu, Ju
- 机构： State Key Laboratory of Bioreactor Engineering; Chemical Engineering Research Center; State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2010
- 关键词：Sodium compounds - Fermentation - Sugar (sucrose)
- 质疑
- Autotransporter domain-dependent enzymatic analysis of a novel extremely thermostable carboxylesterase with high biodegradability towards pyrethroid pesticides被引量：28收藏
- 作者：Cai, Xianghai Wang, Wei Lin, Lin He, Dannong Huang, Gang Shen, Yaling Wei, Wei Wei, Dongzhi
- 机构：East China Univ Sci & Technol;Natl Engn Res Ctr Nanotechnol;Shanghai Univ Med & Hlth Sci
- 来源：SCIENTIFIC REPORTS 2017
- 质疑
- Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp T241被引量：27收藏
- 作者：Zhang, Liaoyuan Guo, Zewang Chen, Jiebo Xu, Quanming Lin, Hui Hu, Kaihui Guan, Xiong Shen, Yaling
- 机构：Fujian Agr & Forestry Univ;E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2016
- 质疑
