成果/Result
- Characterization of a thermostable raw-starch hydrolyzing α-amylase from deep-sea thermophile Geobacillus sp.被引量：43收藏
- 作者：Jiang, Tao Cai, Menghao Huang, Mengmeng He, Hao Lu, Jian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：PROTEIN EXPRESSION AND PURIFICATION 2015
- 关键词：alpha-Amylase Geobacillus sp. Heterologous expression Thermophile
- De Novo Production of Plant 4′-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast被引量：32收藏
- 作者：Qian, Zhilan Yu, Jiahui Chen, Xinjie Kang, Yijia Ren, Yanna Liu, Qi Lu, Jian Zhao, Qing Cai, Menghao
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACS SYNTHETIC BIOLOGY 2022
- 关键词：plant 4 '-deoxyflavones Scutellaria baicalensis Georgi Pichia pastoris transcriptional regulation device fine-tuning pathway control
- A novel pH–precursor–glucose synergic control strategy for dinactin biosynthesis by an arctic actinomycete Streptomyces sp.被引量：25收藏
- 作者：He, Hao Xue, Ying Xu, Ning Yin, Ying Lu, Jian Cai, Menghao Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Collaborative Innovation Center for Biomanufacturing
- 来源：Process Biochemistry 2016
- 关键词：Bacteria - Gene encoding - Biochemistry - Glucose
- Enhancing aspergiolide A production from a shear-sensitive and easy-foaming marine-derived filamentous fungus Aspergillus glaucus by oxygen carrier addition and impeller combination in a bioreactor被引量：21收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Niu, Chuanpeng Zhou, Jiushun Sun, Xueqian Kang, Li Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：BIORESOURCE TECHNOLOGY 2011
- 关键词：Aspergillus glaucus Aspergiolide A Oxygen carrier Shear-sensitive
- An Integrated Control Strategy for the Fermentation of the Marine-Derived Fungus Aspergillus glaucus for the Production of Anti-cancer Polyketide被引量：20收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Zhou, Jiushun Niu, Chuanpeng Kang, Li Sun, Xueqian Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Marine Biotechnology 2012
- 关键词：Biochemistry - Bioreactors - Shear stress - Aspergillus - Bioconversion - Metabolites - Sodium hydroxide - Diseases - Dissolved oxygen - Ketones
- Efficient inhibition of Cronobacter biofilms by chitooligosaccharides of specific molecular weight被引量：14收藏
- 作者：Lu, Jun Chen, Qiming Pan, Bolin Qin, Zhen Fan, Liqiang Xia, Quanming Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2019
- 关键词：Cronobacter spp Biofilms Chitooligosaccharides
- Enhancing aspergiolide A production from a shear-sensitive and easy-foaming marine-derived filamentous fungus Aspergillus glaucus by oxygen carrier addition and impeller combination in a bioreactor被引量：13收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Niu, Chuanpeng Zhou, Jiushun Sun, Xueqian Kang, Li Zhang, Yuanxing
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2011
- 关键词：Oxygen - Turbomachine blades - Biomass - Bioconversion - Bioreactors - Turbine components - Impellers
- Reconstruction of the Genome-Scale Metabolic Model of Saccharopolyspora erythraea and Its Application in the Overproduction of Erythromycin被引量：12收藏
- 作者：Xu, Feng Lu, Ju Ke, Xiang Shao, Minghao Huang, Mingzhi Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：METABOLITES 2022
- 关键词：genome-scale metabolic model Saccharopolyspora erythraea iJL1426 erythromycin production n-propanol process optimization
- Development of a responsive methanol sensor and its application in Pichia pastoris fermentation被引量：10收藏
- 作者：Zhou, XS Lu, J Fan, WM Zhang, YX
- 机构：E China Univ Chem Technol
- 来源：BIOTECHNOLOGY LETTERS 2002
- 关键词：hirudin methanol methanol sensor on-line monitoring Pichia pastoris
- 气升式生物反应器在杂交瘤细胞培养中的应用被引量：9收藏
- 作者：谭文松 陆健 张元兴
- 机构：华东理工大学生化工程研究所
- 来源：《生物工程学报》 1996
- 关键词：生物反应器 杂交瘤细胞 细胞培养 生物制品
- 摘要：在前述研究工作基础上,设计开发了10L规模的动物细胞培养用气升式生物反应器。应用该生物反应器悬浮培养杂交瘤细胞,通过平行试验,考察了该反应器设计的合理性和可靠性。结果显示该反应器不存在限制细胞生长、代谢和产物生成的因素,...
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- Combinatorial strategies for production improvement of red pigments from Antarctic fungusGeomycessp.被引量：8收藏
- 作者：Huang, Hezhou Ding, Lulu Lu, Jian Wang, Nengfei Cai, Menghao
- 机构：East China Univ Sci & Technol;Minist Nat Resources;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF FOOD SCIENCE 2020
- 关键词：Antarctic fungus ARTP fermentation optimization Geomycessp medium development natural red pigments
- Programmable Biosynthesis of Plant-Derived 4′-Deoxyflavone Glycosides by an Unconventional Yeast Consortium被引量：7收藏
- 作者：Kang, Yijia Qian, Zhilan Yu, Haishuang Lu, Jian Zhao, Qing Qiao, Xue Ye, Min Zhou, Xiangshan Cai, Menghao
- 机构：East China Univ Sci & Technol;Shanghai Chenshan Bot Garden;Peking Univ;China Resources Biopharmaceut Co Ltd
- 来源：SMALL METHODS 2024
- 关键词：4 '-deoxyflavone glycosides baicalin co-culture Pichia pastoris plant natural products
- Optimization of nutrients for dinactin production by a marine Streptomyces sp from the high latitude Arctic被引量：6收藏
- 作者：Zhou, Jiao He, Hao Wang, Xiaolong Lu, Jian Zhou, Xiangshan Cai, Menghao Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2015
- 关键词：arctic actinomycete fermentation dinactin medium optimization precursor-feeding strategy
- Transposon insertion mutation of Antarctic psychrotrophic fungus for red pigment production adaptive to normal temperature被引量：6收藏
- 作者：Ding, Lulu Huang, Hezhou Lu, Fengning Lu, Jian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：East China Univ Sci & Technol;China Resources Angde Biotech Pharma Co Ltd;China Resources Biopharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2022
- 关键词：Natural red pigment Antarctic fungus Geomyces sp. Protoplast transformation Transposon mutagenesis
- Comparative omics directed gene discovery and rewiring for normal temperature-adaptive red pigment synthesis by polar psychrotrophic fungus Geomyces sp. WNF-15A被引量：4收藏
- 作者：Long, Haoyu Zhou, Jiawei Ren, Yanna Lu, Jian Wang, Nengfei Liu, Haifeng Zhou, Xiangshan Cai, Menghao
- 机构：East China Univ Sci & Technol;Linyi Univ;China Resources Angde Biotech Pharm Co Ltd;China Resources Biopharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2024
- 关键词：Polar fungi Red pigment Cold-adaptive Comparative omics Food additives
- An Integrated Control Strategy for the Fermentation of the Marine-Derived Fungus Aspergillus glaucus for the Production of Anti-cancer Polyketide被引量：4收藏
- 作者：Cai, Menghao Zhou, Xiangshan Lu, Jian Fan, Weimin Zhou, Jiushun Niu, Chuanpeng Kang, Li Sun, Xueqian Zhang, Yuanxing
- 机构：E China Univ Sci & Technol
- 来源：MARINE BIOTECHNOLOGY 2012
- 关键词：Aspergillus glaucus Fermentation scale-up Aspergiolide A pH shift Marine-derived fungus
- Ammonium sulfate supplementation enhances erythromycin biosynthesis by augmenting intracellular metabolism and precursor supply in Saccharopolyspora erythraea被引量：4收藏
- 作者：Yuan, Yujie Xu, Feng Ke, Xiang Lu, Ju Huang, Mingzhi Chu, Ju
- 机构：East China Univ Sci & Technol
- 来源：BIOPROCESS AND BIOSYSTEMS ENGINEERING 2023
- 关键词：Saccharopolyspora erythraea Erythromycin production Ammonium sulfate Targeted metabolomics Metabolic flux analysis Cellular metabolic mechanism
- 用国产生物反应器培养Vero细胞和狂犬病毒被引量：4收藏
- 作者：张立 范为民 严春 陆健 张元兴 宋瑶君 赵一鸣 陈文兰 俞俊棠
- 机构：华东理工大学生物工程学院
- 来源：《高技术通讯》 1999
- 关键词：生物反应器 细胞培养 Vero细胞 狂犬病毒 培养
- 摘要：介绍了国产生物反应器ＣｅｌＣｕｌ－５０Ａ的特点及性能，并利用此生物反应器培养了Ｖｅｒｏ细胞和狂犬病毒，细胞密度达１．１×１０７ｃｅｌｓ／ｍｌ。
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- Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature被引量：3收藏
- 作者：Lu, Fengning Ren, Yanna Ding, Lulu Lu, Jian Zhou, Xiangshan Liu, Haifeng Wang, Nengfei Cai, Menghao
- 机构：East China Univ Sci & Technol;China Resources Biopharmaceut Co Ltd;China Resources Angde Biotech Pharma Co Ltd;Minist Nat Resources;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2022
- 关键词：Polar fungi Psychrotroph Geomyces sp Red pigment Transposon mutagenesis
- 海洋红树林内生真菌产抗肿瘤活性化合物1403C发酵条件的优化被引量：2收藏
- 作者：康丽 蔡孟浩 范卫民 陆健 周祥山 张元兴
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《生物技术通报》 2011
- 关键词：Halorosellinia sp.(No.1403) 丝状真菌 发酵 优化 pH剪切力
- 摘要：旨在考察pH、溶解氧和剪切力对Halorosellinia sp.(No.1403)发酵过程的影响。结果表明,在发酵中后期及整个发酵过程中控制发酵液的pH恒定对菌体的生长影响不明显,但在不同发酵时期控制不同的恒定pH值对...
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- Bioprocess exploration for thermostable α-amylase production of a deep-sea thermophile Geobacillus sp in high-temperature bioreactor被引量：2收藏
- 作者：Jiang, Tao Huang, Mengmeng He, Hao Lu, Jian Zhou, Xiangshan Cai, Menghao Zhang, Yuanxing
- 机构：East China Univ Sci & Technol
- 来源：PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY 2016
- 关键词：Geobacillus high-temperature bioreactor statistical methodologies thermophile
- A novel pH-precursor-glucose synergic control strategy for dinactin biosynthesis by an arctic actinornycete Streptomyces sp.被引量：2收藏
- 作者：He, Hao Xue, Ying Xu, Ning Yin, Ying Lu, Jian Cai, Menghao Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：PROCESS BIOCHEMISTRY 2016
- 关键词：Dinactin pH-precursor-glucose regulation nonS Succinate
- Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature被引量：1收藏
- 作者：Fengning Lu Yanna Ren Lulu Ding Jian Lu Xiangshan Zhou Haifeng Liu Nengfei Wang Menghao Cai
- 机构：State Key Laboratory of Bioreactor Engineering;China Resources Biopharmaceutical Co.;China Resources Angde Biotech Pharma Co.;First Institute of Oceanography;Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism
- 来源：生物资源与生物加工(英文) 2022
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- Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature (vol 9, 118, 2022)被引量：1收藏
- 作者：Lu, Fengning Ren, Yanna Ding, Lulu Lu, Jian Zhou, Xiangshan Liu, Haifeng Wang, Nengfei Cai, Menghao
- 机构：East China Univ Sci & Technol;China Resources Biopharmaceut Co Ltd;China Resources Angde Biotech Pharm Co;Minist Nat Resources;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2023
- Glutamate-related nitrogen metabolism regulates cold-adaptive synthesis of red pigment in polar fungus Geomyces sp. WNF-15A被引量：1收藏
- 作者：Zhou, Jiawei Long, Haoyu Guo, Yan Lu, Jian Wang, Nengfei Liu, Haifeng Zhou, Xiangshan Cai, Menghao
- 机构：East China Univ Sci & Technol;Linyi Univ;China Resources Angde Biotech Pharm Co Ltd;China Resources Biopharmaceut Co Ltd;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：JOURNAL OF BIOTECHNOLOGY 2025
- 关键词：Cold adaptation Glutamate Nitrogen metabolism Polar fungi Red pigments
- Correction: Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature (Bioresources and Bioprocessing, (2022), 9, 1, (118), 10.1186/s40643-022-00604-5)被引量：1收藏
- 作者：Lu, Fengning Ren, Yanna Ding, Lulu Lu, Jian Zhou, Xiangshan Liu, Haifeng Wang, Nengfei Cai, Menghao
- 机构： State Key Laboratory of Bioreactor Engineering; China Resources Biopharmaceutical Co.; China Resources Angde Biotech Pharma Co.; First Institute of Oceanography; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism
- 来源：Bioresources and Bioprocessing 2023
- Synthetic yeast-bacterium consortium enables co-inducible relayed synthesis of chemicals被引量：0收藏
- 作者：Xu, Mingqiang Yu, Jiahui Chen, Xinjie Li, Xie Guo, Yan Qian, Zhilan Liu, Qi Ren, Yanna Lu, Jian Chen, Xianjun Yang, Yi Cai, Menghao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：METABOLIC ENGINEERING 2026
- 关键词：Synthetic consortiums Co-inducible Quorum sensing Optogenetics Komagataella phaffii Escherichia coli
- Efficient biosynthesis of isopropanol from ethanol by metabolically engineered Escherichia coli被引量：0收藏
- 作者：Wang, Y. Luo, Y. Lu, J. Wu, H.
- 机构：East China Univ Sci & Technol;Dalian Univ Technol
- 来源：NEW BIOTECHNOLOGY 2025
- Correction:Minos and Restless transposon insertion mutagenesis of psychrotrophic fungus for red pigment synthesis adaptive to normal temperature被引量：0收藏
- 作者：Fengning Lu Yanna Ren Lulu Ding Jian Lu Xiangshan Zhou Haifeng Liu Nengfei Wang Menghao Cai
- 机构：State Key Laboratory of Bioreactor Engineering;China Resources Biopharmaceutical Co.;China Resources Angde Biotech Pharma Co.;First Institute of Oceanography;Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism
- 来源：生物资源与生物加工(英文) 2023
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- Comparative omics directed gene discovery and rewiring for normal temperature-adaptive red pigment synthesis by polar psychrotrophic fungus Geomyces sp.WNF-15A被引量：0收藏
- 作者：Haoyu Long Jiawei Zhou Yanna Ren Jian Lu Nengfei Wang Haifeng Liu Xiangshan Zhou Menghao Cai
- 机构：State Key Laboratory of Bioreactor Engineering;School of Chemistry&Chemical Engineering;China Resources Angde Biotech Pharma Co.;China Resources Biopharmaceutical Co.;Shanghai Collaborative Innovation Center for Biomanufacturing
- 来源：合成和系统生物技术(英文) 2024
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