成果/Result
- Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction被引量：134收藏
- 作者：Cao, Xuan Lv, Yu-Bei Chen, Jun Imanaka, Tadayuki Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2016
- 关键词：Limonene Yarrowia lipolytica Neryl diphosphate synthase 1 Limonene synthase
- Heterologous production of α-farnesene in metabolically engineered strains of Yarrowia lipolytica被引量：122收藏
- 作者：Yang, Xia Nambou, Komi Wei, Liujing Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIORESOURCE TECHNOLOGY 2016
- 关键词：Biofuels Fed-batch Metabolic engineering Terpene synthases Yarrowia lipolytica
- Programming the group behaviors of bacterial communities with synthetic cellular communication被引量：117收藏
- 作者：Kong, Wentao Celik, Venhar Liao, Chen Hua, Qiang Lu, Ting
- 机构： Department of Bioengineering; Institute for Genomic Biology; State Key Laboratory of Bioreactor Engineering; Department of Physics
- 来源：Bioresources and Bioprocessing 2014
- 关键词：Behavioral research - Cell engineering - Genes - Mobile telecommunication systems - Population statistics - Timing circuits
- Enhancing linalool production by engineering oleaginous yeast Yarrowia lipolytica被引量：97收藏
- 作者：Cao, Xuan Wei, Liu-Jing Lin, Jia-Yu Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCE TECHNOLOGY 2017
- 关键词：Linalool Yarrowia lipolytica Linalool synthase MVA pathway
- Enhanced squalene biosynthesis in Yarrowia lipolytica based on metabolically engineered acetyl-CoA metabolism被引量：82收藏
- 作者：Huang, Yu-Ying Jian, Xing-Xing Lv, Yu-Bei Nian, Ke-Qing Gao, Qi Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2018
- 关键词：Yarrowia lipolytica Acetyl-CoA Squalene Metabolic network model Terpenoid
- Improved squalene production through increasing lipid contents in Saccharomyces cerevisiae被引量：78收藏
- 作者：Wei, Liu-Jing Kwak, Suryang Liu, Jing-Jing Lane, Stephan Hua, Qiang Kweon, Dae-Hyuk Jin, Yong-Su
- 机构：East China Univ Sci & Technol;Univ Illinois;Univ Illinois;Sungkyunkwan Univ
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2018
- 关键词：beta-oxidation diacylglycerol acyltransferase HMG-CoA reductase lipid bodies Saccharomyces cerevisiae squalene
- Metabolic engineering of β-carotene biosynthesis in Yarrowia lipolytica被引量：72收藏
- 作者：Zhang, Xin-Kai Wang, Dan-Ni Chen, Jun Liu, Zhi-Jie Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2020
- 关键词：Yarrowia lipolytica beta-carotene CRISPR Cas9 system Metabolic engineering Fermenter cultivation
- Biosynthesis of α-Pinene by Genetically Engineered Yarrowia lipolytica from Low-Cost Renewable Feedstocks被引量：63收藏
- 作者：Wei, Liu-Jing Zhong, Yu-Tao Nie, Ming-Yue Liu, Shun-Cheng Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2021
- 关键词：Yarrowia lipolytica alpha-pinene waste cooking oil lignocellulosic hydrolysate
- Elevating Limonene Production in Oleaginous Yeast Yarrowia lipolytica via Genetic Engineering of Limonene Biosynthesis Pathway and Optimization of Medium Composition被引量：59收藏
- 作者：Cheng, Bo-Qian Wei, Liu-Jing Lv, Yu-Bei Chen, Jun Hua, Qiang
- 机构：East China Univ Sci & Technol;SCICBT
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2019
- 关键词：limonene Yarrowia lipolytica carbon source fed-batch fermentation
- Multicopy integrants of crt genes and co-expression of AMP deaminase improve lycopene production in Yarrowia lipolytica被引量：58收藏
- 作者：Zhang, Xin-Kai Nie, Ming-Yue Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Lycopene Yarrowia lipolytica Multicopy integration AMP deaminase overexpression Fermenter cultivation
- CRISPR/Cas9-mediated targeted mutagenesis of bZIP2 in Salvia miltiorrhiza leads to promoted phenolic acid biosynthesis被引量：57收藏
- 作者：Shi, Min Du, Zhiyan Hua, Qiang Kai, Guoyin
- 机构：East China Univ Sci & Technol;Zhejiang Chinese Med Univ;Univ Hawaii Manoa
- 来源：INDUSTRIAL CROPS AND PRODUCTS 2021
- 关键词：Salvia miltiorrhiza bZIP2 Phenolic acids Abscisic acid Transcriptional regulation
- Combining adaptive laboratory evolution and metabolic engineering for efficient erythritol production from crude glycerol by Yarrowia lipolytica被引量：55收藏
- 作者：Zhao, Ling-Xuan Li, Jiawei Wang, Ya-Ting Zhu, Qin-Yi Chen, Jun Liu, Zhi-Jie Liu, Feng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Microbial Metabolism; Key Laboratory of Fermentation Engineering
- 来源：Journal of Biotechnology 2026
- 关键词：Biochemistry - Fermentation - Food additives - Glycerol - Metabolic engineering
- A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza被引量：53收藏
- 作者：Shi, Min Zhu, Ruiyan Zhang, Yi Zhang, Siwei Liu, Tingyao Li, Kunlun Liu, Shucan Wang, Leran Wang, Yao Zhou, Wei Hua, Qiang Kai, Guoyin
- 机构：Zhejiang Chinese Med Univ;East China Univ Sci & Technol;Shanghai Normal Univ
- 来源：METABOLIC ENGINEERING 2022
- 关键词：Salvia miltiorrhiza Hairy root SmWRKY34 SmbZIP3 Phenolic acids Tanshinones
- Antibacterial activity and mechanism of the sesquiterpene δ-cadinene against Listeria monocytogenes被引量：47收藏
- 作者：Qin, Rong Yang, Shengping Fu, Bin Chen, Yang Zhou, Mengzhou Qi, Yonggang Xu, Ning Wu, Qian Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构： Key Laboratory of Fermentation Engineering ; State Key Laboratory of Bioreactor Engineering; Hubei Juhui Agriculture Co.
- 来源：LWT 2024
- 关键词：Biofilms - Cytology - Diseases - Gene expression - Gene Ontology - Listeria - Morphology
- Antibacterial Activity and Mechanism of the Sesquiterpene Δ-Cadinene Against Listeria Monocytogenes and its Application in Milk被引量：46收藏
- 作者：Qin, Rong Yang, Shengping Fu, Bin Chen, Yang Qi, Yonggang Xu, Ning Wu, Qian Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构： Key Laboratory of Fermentation Engineering ; State Key Laboratory of Bioreactor Engineering; Hubei Juhui Agriculture Co.
- 来源：SSRN 2023
- 关键词：Biofilms - Cytology - Diseases - Gene expression - Gene Ontology - Listeria - NuclEIc acids
- Lycopene production in recombinant strains of Escherichia coli is improved by knockout of the central carbon metabolism gene coding for glucose-6-phosphate dehydrogenase被引量：41收藏
- 作者：Zhou, Yan Nambou, Komi Wei, Liujing Cao, Jingjing Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2013
- 关键词：Escherichia coli Glucose-6-phosphate dehydrogenase Lycopene MEP pathway
- In silico profiling of cell growth and succinate production in Escherichia coli NZN111被引量：40收藏
- 作者：Jian, Xingxing Li, Ningchuan Zhang, Cheng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; Science for Life Laboratory; Shanghai Collaborative Innovation Center for Biomanufacturing Technology
- 来源：Bioresources and Bioprocessing 2016
- 关键词：Cell growth - Glucose - Growth kinetics - Metabolism - Metabolites
- Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources被引量：40收藏
- 作者：Zhao, Chen Gu, Deqing Nambou, Komi Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;SCICBT
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Yarrowia lipolytica Metabolomics Pathway abundance Carbon sources Lipid production
- Reconstruction and analysis of a genome-scale metabolic model of the vitamin C producing industrial strain Ketogulonicigenium vulgare WSH-001被引量：40收藏
- 作者：Zou, Wei Liu, Liming Zhang, Jing Yang, Haoru Zhou, Maoda Hua, Qiang Chen, Jian
- 机构： State Key Laboratory of Food Science and Technology; State Key Laboratory of Bioreactor Engineering; The Key Laboratory of Industrial Biotechnology; College of Bioengineering
- 来源：Journal of Biotechnology 2012
- 关键词：Physiological models - Genes - Sulfur compounds - Physiology - Amino acids - Production efficiency
- Designing of a "cheap to run'' fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel被引量：39收藏
- 作者：Nambou, Komi Zhao, Chen Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCE TECHNOLOGY 2014
- 关键词：Biodiesel Fermentation Lipids Phosphate limitation Yarrowia lipolytica
- In silico analysis and experimental improvement of taxadiene heterologous biosynthesis in Escherichia coli被引量：37收藏
- 作者：Meng, Hailin Wang, Yong Hua, Qiang Zhang, Siliang Wang, Xiaoning
- 机构： School of Bioscience and Bioengineering; Key Laboratory of Synthetic Biology; State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioprocess Engineering 2011
- 关键词：Thermodynamic properties - Chromosomes - Lipids - Escherichia coli - Biochemistry
- Pathway engineering and medium optimization for α-farnesene biosynthesis in oleaginous yeast Yarrowia lipolytica被引量：37收藏
- 作者：Liu, Shun-Cheng Liu, Zhijie Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：?-farnesene acetyl-CoA Metabolic engineering MVA pathway Medium optimization
- Analysis of metabolic fluxes for better understanding of mechanisms related to lipid accumulation in oleaginous yeast Trichosporon cutaneum被引量：35收藏
- 作者：Liu, Zhijie Gao, Yang Chen, Jun Imanaka, Tadayuki Bao, Jie Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Biotechnology
- 来源：Bioresource Technology 2013
- 关键词：Yeast - Biodiesel - Metabolism - Sulfur compounds - Nitrogen compounds - Enzymes
- Combining metabolic engineering and adaptive evolution to enhance the production of dihydroxyacetone from glycerol by Gluconobacter oxydans in a low-cost way被引量：35收藏
- 作者：Lu, Leifang Wei, Liujing Zhu, Kun Wei, Dongzhi Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Bioresource Technology 2012
- 关键词：Cost engineering - Metabolic engineering - Gene expression - Glycerol - Cultivation - Carbon
- Quantification and analysis of metabolic characteristics of aerobic succinate-producing Escherichia coli under different aeration conditions被引量：33收藏
- 作者：Liu, Zhijie Wang, Xinran Qi, Qingsheng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Microbial Technology
- 来源：Process Biochemistry 2012
- 关键词：Oxygen supply - Physiological models - Gene expression - Metabolism
- Antimicrobial activity and mechanism of α-copaene against foodborne pathogenic bacteria and its application in beef soup被引量：32收藏
- 作者：Chen, Shangyan Zheng, Hao Yang, Shengping Qi, Yonggang Li, Wei Kang, Sini Hu, Han Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构：Hubei Univ Technol;East China Univ Sci & Technol;Hubei Juhui Agr Co Ltd
- 来源：LWT-FOOD SCIENCE AND TECHNOLOGY 2024
- 关键词：Foodborne pathogenic bacteria Antibacterial mechanism Antibiofilm activity alpha-Copaene Biosafety
- Functions of membrane-bound alcohol dehydrogenase and aldehyde dehydrogenase in the bio-oxidation of alcohols in Gluconobacter oxydans DSM 2003被引量：31收藏
- 作者：Wei, Liu-Jing Zhou, Ji-Lai Zhu, Dan-Ni Cai, Bai-Yi Lin, Jin-Ping Hua, Qiang Wei, Dong-Zhi
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioprocess Engineering 2012
- 关键词：Enzymes - Oxidation - Aldehydes
- Multiple gene integration to promote erythritol production on glycerol in Yarrowia lipolytica被引量：27收藏
- 作者：Zhang, Ling Nie, Ming-Yue Liu, Feng Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2021
- 关键词：Erythritol Glycerol utilization Multiple gene integration Ribose 5-phosphate isomerase Yarrowia lipolytica
- Utilization of nanoemulsion to enhance antibacterial capacity of Zanthoxylum bungeanum pericarp essential oils against foodborne pathogenic bacteria被引量：27收藏
- 作者：Zheng, Hao Chen, Shangyan Liu, Zao Zhou, Gao Zhang, Xuan Kang, Sini Hua, Qiang Wu, Yongkang Liu, Zhijie
- 机构：Hubei Univ Technol;East China Univ Sci & Technol;Hubei Juhui Agr Co Ltd
- 来源：LWT-FOOD SCIENCE AND TECHNOLOGY 2024
- 关键词：Foodborne pathogenic bacteria Zanthoxylum bungeanum pericarp essential oil Antibacterial mechanism Nanoemulsion
- Yarrowia lipolytica as a Metabolic Engineering Platform for the Production of Very-Long-Chain Wax Esters被引量：27收藏
- 作者：Gao, Qi Yang, Jing-Lin Zhao, Xin-Ru Liu, Shun-Cheng Liu, Zhi-Jie Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2020
- 关键词：Yarrowia lipolytica very-long-chain fatty acids fatty alcohols wax esters
