成果/Result
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：Cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- Challenges of quaternary ammonium antimicrobial agents: Mechanisms, resistance, persistence and impacts on the microecology被引量：233收藏
- 作者：Zhang, Jiaxin Cheng, Lei Li, Hao Chen, Xi Zhang, Lin Shan, Tiantian Wang, Jiannan Chen, Ding Shen, Jiawei Zhou, Xinxuan Gou, Lichen Zhang, Lixin Zhou, Xuedong Ren, Biao
- 机构： State Key Laboratory of Oral Diseases; Department of Operative Dentistry and Endodontics; Department of Endodontics; National Center for Stomatology; State Key Laboratory of Bioreactor Engineering
- 来源：Science of the Total Environment 2025
- 关键词：Ammonium compounds - Disinfectants - Macroinvertebrates
- Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces被引量：143收藏
- 作者：Wang, Weishan Li, Shanshan Li, Zilong Zhang, Jingyu Fan, Keqiang Tan, Gaoyi Ai, Guomin Lam, Sin Man Shui, Guanghou Yang, Zhiheng Lu, Hongzhong Jin, Pinjiao Li, Yihong Chen, Xiangyin Xia, Xuekui Liu, Xueting Dannelly, H. Kathleen Yang, Chen Yang, Yi Zhang, Siliang Alterovitz, Gil Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Chinese Acad Sci;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2020
- 关键词：Ketones - Metabolism - Biochemistry - Bacteria - Metabolites - Glycerol
- A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes被引量：88收藏
- 作者：Zhao, Xiangxiang Li, Shanshan Liu, Guang Wang, Zhong Yang, Zhiheng Zhang, Quanwei Liang, Mindong Liu, Jiakun Li, Zilong Tong, Yaojun Zhu, Guoliang Wang, Xinye Jiang, Lan Wang, Weishan Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Agr Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：CRISPR-Cas12a Aptamer Biosensing platform Diverse analyte Alpha fetoprotEIn detection Cocaine detection
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Development of an Escherichia coli-based diterpenoid bioproduction foundry被引量：57收藏
- 作者：Guo, Ke Liu, Ping Wang, Ziwei Wang, Shiwei Wei, Jinshuo Zhang, Ziyang Zhao, Chuanfu Qin, Qiumei Zhang, Lixin Li, Zhenghong Wang, Weishan
- 机构： The College of Life Sciences; R&D Innovation Center; The School of Pharmacy; State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Microbial Diversity and Innovative Utilization
- 来源：Chemical Engineering Journal 2026
- 关键词：Biochemical engineering - Escherichia coli - Genes - Genetic engineering - Modular construction - Strain
- Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis被引量：54收藏
- 作者：Wu, Fan Zhang, Jing Song, Fuhang Wang, Sanshan Guo, Hui Wei, Qi Dai, Huanqin Chen, Xiangyin Xia, Xuekui Liu, Xueting Zhang, Lixin Yu, Jin-Quan Lei, Xiaoguang
- 机构：Peking Univ;Peking Univ;Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：ACS CENTRAL SCIENCE 2020
- Polyketide pesticides from actinomycetes被引量：52收藏
- 作者：Li, Shanshan Yang, Bowen Tan, Gao-Yi Ouyang, Li-Ming Qiu, Shiwen Wang, Weishan Xiang, Wensheng Zhang, Lixin
- 机构：Chinese Acad Agr Sci;East China Univ Sci & Technol;Chinese Acad Sci;Northeast Agr Univ;Univ Chinese Acad Sci
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Crop protection - Metabolites - Bacteria
- Hydrogenase as the basis for green hydrogen production and utilization被引量：46收藏
- 作者：Ji, Haishuo Wan, Lei Gao, Yanxin Du, Ping Li, Wenjin Luo, Hang Ning, Jiarui Zhao, Yingying Wang, Huangwei Zhang, Lixin Zhang, Liyun
- 机构：Nankai Univ;Max Planck Inst Chem Energy Convers;Nankai Univ;East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST
- 来源：JOURNAL OF ENERGY CHEMISTRY 2023
- 关键词：Hydrogenase Biological H-2 energy Oxygen tolerance Artificial photosynthesis Biofuel cells
- Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro被引量：42收藏
- 作者：Cao, Jiaqian Yao, Yongpeng Fan, Keqiang Tan, Gaoyi Xiang, Wensheng Xia, Xuekui Li, Shanshan Wang, Weishan Zhang, Lixin
- 机构：State Key Lab Microbial Resources;Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Agr Sci;Qilu Univ Technol
- 来源：SCIENCE ADVANCES 2018
- 关键词：Biosensors - Transcription - DNA - Binding sites - Signal transduction
- Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity被引量：41收藏
- 作者：Zhang, Donghui Shi, Chao Cong, Zihao Chen, Qi Bi, Yufang Zhang, Junyu Ma, Kaiqian Liu, Shiqi Gu, Jiawei Chen, Minzhang Lu, Ziyi Zhang, Haodong Xie, Jiayang Xiao, Ximian Liu, Longqiang Jiang, Weinan Shao, Ning Chen, Sheng Zhou, Min Shao, Xiaoyan Dai, Yidong Li, Maoquan Zhang, Lixin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Ruijin Rehabil Hosp;Tongji Univ
- 来源：ADVANCED SCIENCE 2022
- 关键词：antifungal agents fungal keratitis host defense peptide mimicking poly(DL-diaminopropionic acid) beta-peptide polymers
- TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis被引量：39收藏
- 作者：Xu, Yurong Ke, Meilan Li, Jie Tang, Yaqian Wang, Nian Tan, Guoqing Wang, Yansheng Liu, Ruihua Bai, Linquan Zhang, Lixin Wu, Hang Zhang, Buchang
- 机构：Anhui Univ;Hefei Normal Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Xinyu Pharmaceut Co Ltd
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2019
- 关键词：lincomycin SLCG_2919 Streptomyces lincolnensis TetR family transcriptional regulator
- Characterizing Y224 conformational flexibility in FtmOx1-catalysis using 19F NMR spectroscopy被引量：36收藏
- 作者：Wang, Xinye Yang, Lingyun Wang, Shenlin Wang, Jun Li, Kelin Naowarojna, Nathchar Ju, Yi Ye, Ke Han, Yuchen Yan, Wupeng Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构： State Key Laboratory of Bioreactor Engineering; iHuman Institute; School of Life Sciences and Biotechnology; Department of Chemistry; Program of Chemistry
- 来源：Catalysis Science and Technology 2024
- 关键词：Biosynthesis - Complexation - Conformations - Nuclear magnetic resonance spectroscopy
- High-yield porphyrin production through metabolic engineering and biocatalysis被引量：34收藏
- 作者：Chen, Haihong Wang, Yaohong Wang, Weishan Cao, Ting Zhang, Lu Wang, Zhengduo Chi, Xuran Shi, Tong Wang, Huangwei He, Xinwei Liang, Mindong Yang, Mengxue Jiang, Wenyi Lv, Dongyuan Yu, Jiaming Zhu, Guoliang Xie, Yongtao Gao, Bei Wang, Xinye Liu, Xueting Li, Youyuan Ouyang, Limin Zhang, Jingyu Liu, Huimin Li, Zilong Tong, Yaojun Xia, Xuekui Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Qilu Univ Technol
- 来源：NATURE BIOTECHNOLOGY 2025
- 关键词：Catalysis - Diagnosis - Fermentation - Medical applications - Metabolic engineering
- Transcriptional regulation of a leucine-responsive regulatory protEIn for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis被引量：33收藏
- 作者：Xu, Yurong Tang, Yaqian Wang, Nian Liu, Jing Cai, Xinlu Cai, Hongyi Li, Jie Tan, Guoqing Liu, Ruihua Bai, Linquan Zhang, Lixin Wu, Hang Zhang, Buchang
- 机构：Anhui Univ;Hefei Normal Univ;Xinyu Pharmaceut Co Ltd;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Leucine-responsive regulatory protEIn Metabolic regulation Streptomyces lincolnensis Lincomycin Transcriptional activator
- Genome-based mining of new antimicrobial meroterpenoids from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：32收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Zhu, Guoliang Liu, Miaomiao Dai, Huanqin Hsiang, Tom Liu, Xueting Zhang, Lixin Quinn, Ronald J. Feng, Yunjiang
- 机构：Griffith Univ;Chinese Acad Sci;East China Univ Sci & Technol;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Meroterpenoids Phytopathogenic fungus Bipolaris sorokiniana Genome-based mining Antimicrobial activity
- Learn from microbial intelligence for avermectins overproduction被引量：32收藏
- 作者：Gao, Qiang Tan, Gao-Yi Xia, Xuekui Zhang, Lixin
- 机构：East China Univ Sci & Technol;Tianjin Univ Sci & Technol;Shandong Acad Sci;Qingdao Natl Lab Marine Sci & Technol
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2017
- Systematic development of a highly efficient cell factory for 5-aminolevulinic acid production被引量：28收藏
- 作者：Zhou, Houming Zhang, Chengyu Li, Zilong Xia, Menglei Li, Zhenghong Wang, Zhengduo Tan, Gao-Yi Luo, Ying Zhang, Lixin Wang, Weishan
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Tianjin Univ Sci & Technol
- 来源：TRENDS IN BIOTECHNOLOGY 2024
- 关键词：Agriculture - Metabolic engineering - Metabolism
- Characterization of an Lrp/AsnC family regulator SCO3361, controlling actinorhodin production and morphological development in Streptomyces coelicolor被引量：26收藏
- 作者：Liu, Jing Li, Jie Dong, Hong Chen, Yunfu Wang, Yansheng Wu, Hang Li, Changrun Weaver, David T. Zhang, Lixin Zhang, Buchang
- 机构：Anhui Univ;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：Lrp/AsnC family Streptomyces coelicolor SCO3361 Act production Morphological development Interactional regulation
- Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis被引量：26收藏
- 作者：Xu, Yurong Tan, Guoqing Ke, Meilan Li, Jie Tang, Yaqian Meng, Sitong Niu, Jingjing Wang, Yansheng Liu, Ruihua Wu, Hang Bai, Linquan Zhang, Lixin Zhang, Buchang
- 机构：Anhui Univ;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Xinyu Pharmaceut Co Ltd
- 来源：JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY 2018
- 关键词：Streptomyces lincolnensis Lincomycin S-adenosylmethionine (SAM) SAM synthetase
- A Gene Cluster Encoding a Nonribosomal Peptide Synthetase-Like Enzyme Catalyzes New Γ-Aromatic Butenolides被引量：25收藏
- 作者：Meng, Qingzhou Wang, Xinzhu Dai, Huanqin Assani, Israa Zhang, Mengting Zhao, Peipei Li, Longfen Yin, Xin Qu, Kunyu Wu, Qinghua Pan, Yang Zhang, Lixin Xia, Xuekui
- 机构： Biology Institute; School of Pharmacy; State Key Laboratory of Mycology; Savaid Medical School; Department of Pharmaceutical Engineering
- 来源：SSRN 2023
- 关键词：Aromatic compounds - Biochemistry - Enzymes - Gene encoding - Metabolites
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus被引量：21收藏
- 作者：Qi, Jun Jiang, Lan Zhao, Peipei Chen, Haiyan Jia, Xiaopeng Zhao, Liya Dai, Huanqin Hu, Jiansen Liu, Changheng Shim, Sang Hee Xia, Xuekui Zhang, Lixin
- 机构：Qilu Univ Technol;East China Univ Sci & Technol;Guangxi Univ;Duksung Womens Univ;Duksung Womens Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Apostichopus japonicus Chaetomium globosum Genome mining Chaetoglobosins Azaphilones Antimicrobial activity
- Purification and characterization of a novel β-1,3-glucanase from Arca inflata and its immune-enhancing effects被引量：20收藏
- 作者：Li, Chunlei Wen, Yao He, Ying Zhu, Jianhua Yin, Xin Yang, Jianing Zhang, Lixin Song, Liyan Xia, Xuekui Yu, Rongmin
- 机构：Jinan Univ;Qilu Univ Technol;Jinan Univ;East China Univ Sci & Technol
- 来源：FOOD CHEMISTRY 2019
- 关键词：Arca inflata Endo-beta-1,3-Glucanase Biochemical characterization Immune-enhancing activity GlycoprotEIn
- Dissecting the Mechanism of the Nonheme Iron Endoperoxidase FtmOx1 Using Substrate Analogues被引量：19收藏
- 作者：Zhu, Guoliang Yan, Wupeng Wang, Xinye Cheng, Ronghai Naowarojna, Nathchar Wang, Kun Wang, Jun Song, Heng Wang, Yuyang Liu, Hairong Xia, Xuekui Costello, Catherine E. Liu, Xueting Zhang, Lixin Liu, Pinghua
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Boston Univ;Wuhan Univ;Qilu Univ Technol
- 来源：JACS AU 2022
- 关键词：FtmOx1 nonheme iron enzymes endoperoxidation hydroxylation dehydrogenation X-ray structure
- New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucor rouxii被引量：19收藏
- 作者：He, Wenni Li, Yao Qin, Yuejie Tong, Xiaomei Song, Zhijun Zhao, Yu Wei, Ran Li, Li Dai, Huanqin Wang, Wenzhao Luo, Houwei Ye, Xin Zhang, Lixin Liu, Xueting
- 机构：Chinese Acad Sci;Chinese Acad Med Sci;Peking Union Med Coll;Univ Chinese Acad Sci;Chinese Acad Med Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2017
- 关键词：Cryptotanshinone Biotransformation Mucor rouxii Anti-influenza A virus activity
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
