成果/Result
- Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells被引量：221收藏
- 作者：Yuan, Yuan Liu, Changsheng Qjan, Jiangchao Wang, Jing Zhang, Yuan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2010
- 关键词：Hydroxyapatite nanoparticles Cytotoxicity Apoptosis-induction Human hepatoma HepG2 cells Size-mediated Mitochondrial-dependent pathway
- Bioinspired trimodal macro/micro/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect被引量：207收藏
- 作者：Tang, Wei Lin, Dan Yu, Yuanman Niu, Haoyi Guo, Han Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACTA BIOMATERIALIA 2016
- 关键词：Trimodal macro/micro/nano-porous architecture Recombinant human bone morphogenetic protein-2 Critical size bone defect Mesoporous bioactive glass
- Long-circulating polymeric nanoparticles bearing a combinatorial coating of PEG and water-soluble chitosan被引量：191收藏
- 作者：Sheng, Yan Liu, Changsheng Yuan, Yuan Tao, Xinyi Yang, Fan Shan, Xiaoqian Zhou, Huanjun Xu, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2009
- 关键词：Polymeric nanoparticles Polyethylene glycol Water-soluble chitosan Long-circulating Biodistribution
- Magnesium modification of a calcium phosphate cement alters bone marrow stromal cell behavior via an integrin-mediated mechanism被引量：191收藏
- 作者：Zhang, Jing Ma, Xiaoyu Lin, Dan Shi, Hengsong Yuan, Yuan Tang, Wei Zhou, Huanjun Guo, Han Qian, Jiangchao Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2015
- 关键词：Magnesium/calcium phosphate cements Cell adhesion Osteogenic differentiation Fibronectin Integrin
- Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors被引量：190收藏
- 作者：Chen, Qj Yu, Shan Zhang, Donghui Zhang, Wenjing Zhang, Haodong Zou, Jingcheng Mao, Zhengwei Yuan, Yuan Gao, Changyou Liu, Runhui
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2019
- 关键词：Peptides - Chain length - Adhesives - Cells - Scaffolds (biology) - Cell engineering
- Degradable, antibacterial silver exchanged mesoporous silica spheres for hemorrhage control被引量：182收藏
- 作者：Dai, Chenglong Yuan, Yuan Liu, Changsheng Wei, Jie Hong, Hua Li, Xiaosheng Pan, Xiaohua
- 机构：E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOMATERIALS 2009
- 关键词：Mesoporous silica sphere Hemostatic efficiency Degradation Antibacterial
- A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles-capped mesoporous silica被引量：171收藏
- 作者：Gan, Qi Lu, Xunyu Yuan, Yuan Qian, Jiangchao Zhou, Huanjun Lu, Xun Shi, Jianlin Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2011
- 关键词：pH-responsive Mesoporous silica Magnetic Gate-like Biocompatibility
- Injectable Double-Crosslinked Adhesive Hydrogels with High Mechanical Resilience and Effective Energy Dissipation for Joint Wound Treatment被引量：169收藏
- 作者：Chen, Kai Wu, Zihan Liu, Yutong Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED FUNCTIONAL MATERIALS 2022
- 关键词：adhesive hydrogels dynamic environment energy dissipation joint wound treatment mechanical resilience
- N2-Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle被引量：165收藏
- 作者：Cai, Bolei Lin, Dan Li, Yan Wang, Le Xie, Jirong Dai, Taiqiang Liu, Fuwei Tang, Mingyue Tian, Lei Yuan, Yuan Kong, Liang Shen, Steve G. F.
- 机构：Shanghai Jiao Tong Univ;Shanghai Res Inst Stomatol;Fourth Mil Med Univ;Fourth Mil Med Univ;Fourth Mil Med Univ
- 来源：ADVANCED SCIENCE 2021
- 关键词：bone regeneration interleukin-8 neutrophils stem cell recruitment stromal cell-derived factor-1 alpha
- Bioinspired, Injectable, Quaternized Hydroxyethyl Cellulose Composite Hydrogel Coordinated by Mesocellular Silica Foam for Rapid, Noncompressible Hemostasis and Wound Healing被引量：158收藏
- 作者：Wang, Chengwei Niu, Haoyi Ma, Xiaoyu Hong, Hua Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Wego Biol Technol Co Ltd
- 来源：ACS APPLIED MATERIALS & INTERFACES 2019
- 关键词：hydroxyethyl cellulose mesocellular foam hemostasis antibacterial wound healing
- In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells被引量：138收藏
- 作者：Lu, Xun Qian, Jiangchao Zhou, Huanjun Gan, Qi Tang, Wei Lu, Jingxiong Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF NANOMEDICINE 2011
- 关键词：silica nanoparticles cytotoxicity apoptosis HepG2 cells mitochondrial-dependent pathway oxidative stress
- Sulfated polysaccharide directs therapeutic angiogenesis via endogenous VEGF secretion of macrophages被引量：134收藏
- 作者：Yu, Yuanman Dai, Kai Gao, Zehua Tang, Wei Shen, Tong Yuan, Yuan Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：SCIENCE ADVANCES 2021
- 关键词：Diseases
- RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration被引量：133收藏
- 作者：Zhang, Jing Zhou, Huanjun Yang, Kai Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2013
- 关键词：Calcium silicate/calcium phosphate cement rhBMP-2 Bone regeneration Hierarchical porosity
- Rapid initiation of guided bone regeneration driven by spatiotemporal delivery of IL-8 and BMP-2 from hierarchical MBG-based scaffold被引量：126收藏
- 作者：Lin, Dan Chai, Yanjun Ma, Yifan Duan, Bing Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2019
- 关键词：Rapid initiation BMP-2 IL-8 MBG In situ guided bone regeneration
- Tannic acid-loaded mesoporous silica for rapid hemostasis and antibacterial activity被引量：124收藏
- 作者：Wang, Chengwei Zhou, Huayi Niu, Haoyi Ma, Xiaoyu Yuan, Yuan Hong, Hua Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Wego Biol Technol Co Ltd
- 来源：BIOMATERIALS SCIENCE 2018
- 关键词：Flavonoids - Grafting (chemical) - Blood - Bacteria - Tannins
- Harnessing 4D Printing Bioscaffolds for Advanced Orthopedics被引量：124收藏
- 作者：Chen, Xi Han, Shuyan Wu, Weihui Wu, Zihan Yuan, Yuan Wu, Jun Liu, Changsheng
- 机构：East China Univ Sci & Technol;Sun Yat Sen Univ
- 来源：SMALL 2022
- 关键词：bioprinting bone regeneration scaffolds shape-memory materials tissue engineering
- A dual-delivery system of pH-responsive chitosan-functionalized mesoporous silica nanoparticles bearing BMP-2 and dexamethasone for enhanced bone regeneration被引量：122收藏
- 作者：Gan, Qi Zhu, Jiaoyang Yuan, Yuan Liu, Honglai Qian, Jiangchao Li, Yongsheng Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2015
- 关键词：Bone - Targeted drug delivery - Sol-gels - Sol-gel process - Silica nanoparticles - Mesoporous materials - Proteins - Controlled drug delivery
- Charge-Reversal APTES-Modified Mesoporous Silica Nanoparticles with High Drug Loading and Release Controllability被引量：121收藏
- 作者：Wang, Yifeng Sun, Yi Wang, Jine Yang, Yang Li, Yulin Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：mesoporous silica nanocarriers charge reversal doxorubicin drug delivery pH responsive
- Nanotechnology platforms for cancer immunotherapy被引量：113收藏
- 作者：Yang, Zhaogang Ma, Yifan Zhao, Hai Yuan, Yuan Kim, Betty Y. S.
- 机构：Univ Texas Southwestern Med Ctr Dallas;Ohio State Univ;Univ Texas MD Anderson Canc Ctr;East China Univ Sci & Technol
- 来源：WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY 2020
- 关键词：cancer immunotherapy immunomodulatory agents nanoplatforms
- Mitochondria-Targeted Hydroxyapatite Nanoparticles for Selective Growth Inhibition of Lung Cancer in Vitro and in Vivo被引量：106收藏
- 作者：Sun, Yi Chen, Yaying Ma, Xiaoyu Yuan, Yuan Liu, Changsheng Kohn, Joachim Qian, Jiangchao
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Rutgers State Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：hydroxyapatite nanoparticles lung cancer mitochondrion-targeted cytotoxicity uptake
- Injectable Hydrogel with NIR Light-Responsive, Dual-Mode PTH Release for Osteoregeneration in Osteoporosis被引量：100收藏
- 作者：Kuang, Lijun Huang, Jinghuan Liu, Yutong Li, Xiaolin Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6
- 来源：ADVANCED FUNCTIONAL MATERIALS 2021
- 关键词：dual-mode release injectable hydrogels near-infrared light osteoporotic bone repair parathyroid hormone pores formation
- Self-Assembled Injectable Nanocomposite Hydrogels Coordinated by in Situ Generated CaP Nanoparticles for Bone Regeneration被引量：96收藏
- 作者：Kuang, Lijun Ma, Xiaoyu Ma, Yifan Yao, Yuan Tariq, Muhammad Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2019
- 关键词：in situ generated CaP nanoparticles injectable nanocomposite hydrogels self-assembly Apt-functionalized bone regeneration
- Rejuvenating Aged Bone Repair through Multihierarchy Reactive Oxygen Species-Regulated Hydrogel被引量：93收藏
- 作者：He, Zirui Sun, Chuanhao Ma, Yifan Chen, Xi Wang, Ying Chen, Kai Xie, Fangru Zhang, Yan Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Ohio State Univ
- 来源：ADVANCED MATERIALS 2024
- 关键词：aged bone regeneration poly(diselenide-carbonate) nanomicelles ROS-scavenging hydrogel senescent microenvironment
- Amphiphilic Polymer-Mediated Formation of Laponite-Based Nanohybrids with Robust Stability and pH Sensitivity for Anticancer Drug Delivery被引量：93收藏
- 作者：Wang, Guoying Maciel, Dina Wu, Yilun Rodrigues, Joao Shi, Xiangyang Yuan, Yuan Liu, Changsheng Tomas, Helena Li, Yulin
- 机构：Univ Madeira;E China Univ Sci & Technol;E China Univ Sci & Technol;Donghua Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2014
- 关键词：amphiphilic polymer Laponite doxorubicin pH sensitive anticancer
- Dual mechanism β-amino acid polymers promoting cell adhesion被引量：92收藏
- 作者：Chen, Qi Zhang, Donghui Zhang, Wenjing Zhang, Haodong Zou, Jingcheng Chen, Mingjiao Li, Jin Yuan, Yuan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NATURE COMMUNICATIONS 2021
- Preparation of hemoglobin-loaded nano-sized particles with porous structure as oxygen carriers被引量：89收藏
- 作者：Zhao, Jian Liu, Chang-Sheng Yuan, Yuan Tao, Xin-Yi Shan, Xiao-Qian Sheng, Yan Wu, Fan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOMATERIALS 2007
- 关键词：nanoparticles hemoglobin encapsulation efficiency pore-connecting efficiency oxygen-carrying capacity circulation time
- Multifunctional Carbon Dots for Biomedical Applications: Diagnosis, Therapy, and Theranostic被引量：86收藏
- 作者：Wang, Jiayi Fu, Yu Gu, Zhanghao Pan, Hao Zhou, Panyu Gan, Qi Yuan, Yuan Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Tongji Univ;Naval Med Univ;East China Univ Sci & Technol
- 来源：SMALL 2024
- 关键词：carbon dots diagnosis therapy theranostic
- Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells被引量：86收藏
- 作者：Tang, Wei Yuan, Yuan Liu, Changsheng Wu, Yuequn Lu, Xun Qian, Jiangchao
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：NANOMEDICINE 2014
- 关键词：apoptosis induction cell type-dependent cytotoxicity cellular uptake and distribution hydroxyapatite nanoparticles intracellular calcium concentration reactive oxygen species
- A viscoelastic PEGylated poly(glycerol sebacate)-based bilayer scaffold for cartilage regeneration in full-thickness osteochondral defect被引量：86收藏
- 作者：Lin, Dan Cai, Bolei Wang, Le Cai, Lisha Wang, Zihao Xie, Jirong Lv, Qian-xin Yuan, Yuan Liu, Changsheng Shen, Steve G. F.
- 机构：Shanghai Jiao Tong Univ;Shanghai Res Inst Stomatol;East China Univ Sci & Technol;Fourth Mil Med Univ;Jiamusi Univ
- 来源：BIOMATERIALS 2020
- 关键词：Viscoelastic PEGylated poly(glycerol sebacate) Cartilage regeneration Osteochondral regeneration Full-thickness articular defects Bilayer scaffold
- Exosomal mRNAs for Angiogenic-Osteogenic Coupled Bone Repair被引量：83收藏
- 作者：Ma, Yifan Sun, Lili Zhang, Jingjing Chiang, Chi-ling Pan, Junjie Wang, Xinyu Kwak, Kwang Joo Li, Hong Zhao, Renliang Rima, Xilal Y. Zhang, Chi Zhang, Anan Liu, Yutong He, Zirui Hansford, Derek Reategui, Eduardo Liu, Changsheng Lee, Andrew S. Yuan, Yuan Lee, Ly James
- 机构：Ohio State Univ;Ohio State Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Spot Biosyst Ltd
- 来源：ADVANCED SCIENCE 2023
- 关键词：PEGylated poly (glycerol sebacate) acrylate (PEGS-A) hydrogel small extracellular vesicles carrying therapeutic mRNAs and associated microRNAs track-etched membrane-based nanoelectroporation (TM-nanoEP) vascular endothelial growth factor A (VEGF-A) bone morphogenetic protein 2 (BMP-2) mRNAs coupled angiogenic-osteogenic regeneration
