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( 任职于 生物工程学院)
生物工程专业：博士生导师/硕士生导师 生物化学与分子生物学专业：博士生导师/硕士生导师 生物工程领域：工程硕士导师 生物反应器工程国家重点实验室，教授。2004年毕业于清华大学生物科学与技术系，获理学学士学位。同年赴美密歇根大学分子、细胞与发育生物学系攻读博士学位。2010年获得博士学位并于密歇根大学及霍华德休斯医学研究所从事博士后研究工作。代表性研究成果发表在eLife、Nature Structural & Molecular Biology、 Journal of Biological Chemistry等期刊上。2014年1月加入... 详细>>
- Developmental ROS individualizes organismal stress resistance and lifespan被引量：194收藏
- 作者：Bazopoulou, Daphne Knoefler, Daniela Zheng, Yongxin Ulrich, Kathrin Oleson, Bryndon J. Xie, Lihan Kim, Minwook Kaufmann, Anke Lee, Young-Tae Dou, Yali Chen, Yong Quan, Shu Jakob, Ursula
- 机构：Univ Michigan;East China Univ Sci & Technol;SCICB;Michigan Med;Chinese Acad Sci
- 来源：NATURE 2019
- 质疑
- Towards efficient terpenoid biosynthesis: manipulating IPP and DMAPP supply被引量：82收藏
- 作者：Wang, Qin Quan, Shu Xiao, Han
- 机构：Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Terpenoid Mevalonate pathway 2-C-Methyl-D-erythritol 4-phosphate (MEP) Isopentenyl diphosphate (IPP) Dimethylallyl diphosphate (DMAPP) Biosynthesis
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- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
- 质疑
- Visualizing chaperone-assisted protein folding被引量：51收藏
- 作者：Horowitz, Scott Salmon, Loic Koldewey, Philipp Ahlstrom, Logan S. Martin, Raoul Quan, Shu Afonine, Pavel V. van den Bedem, Henry Wang, Lili Xu, Qingping Trievel, Raymond C. Brooks, Charles L., III Bardwell, James C. A.
- 机构：Univ Michigan;Howard Hughes Med Inst;Univ Michigan;East China Univ Sci & Technol;Lawrence Berkeley Natl Lab
- 来源：NATURE STRUCTURAL & MOLECULAR BIOLOGY 2016
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- An enzyme-based biosensor for monitoring and engineering protein stability in vivo被引量：30收藏
- 作者：Ren, Chang Wen, Xin Mencius, Jun Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2021
- 关键词：biosensor protein stability protein engineering deep mutational scanning
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- Selection and screening strategies in directed evolution to improve protein stability被引量：27收藏
- 作者：Ren, Chang Wen, Xin Mencius, Jun Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Directed evolution Protein folding Protein stability Cell surface display Cell-free display Reporter protein Stability biosensor
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- Advances in Biosynthesis of Natural Products from Marine Microorganisms被引量：25收藏
- 作者：Zhou, Quan Hotta, Kinya Deng, Yaming Yuan, Rui Quan, Shu Chen, Xi
- 机构：Northwest Univ;Genetech Biotechnol Pte Ltd;East China Univ Sci & Technol
- 来源：MICROORGANISMS 2021
- 关键词：marine natural products genomic screening heterologous expression combinatorial biosynthesis
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- Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation被引量：24收藏
- 作者：Chen, Guochao Wang, Duo Wu, Bin Yan, Fuxiang Xue, Hongjuan Wang, Quanmeng Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;Chinese Acad Sci;Huazhong Agr Univ;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2020
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- Chaperone Spy Protects Outer Membrane Proteins from Folding Stress via Dynamic Complex Formation被引量：21收藏
- 作者：He, Wei Yu, Gangjin Li, Tianpeng Bai, Ling Yang, Yuanyuan Xue, Zixiao Pang, Yonghao Reichmann, Dana Hiller, Sebastian He, Lichun Liu, Maili Quan, Shu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Hebrew Univ Jerusalem;Univ Basel;Univ Chinese Acad Sci
- 来源：MBIO 2021
- 关键词：chaperone outer membrane protein biogenesis folding stress protein-protein interaction nuclear magnetic resonance spectroscopy
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- Fluorogenic sensing of amorphous aggregates, amyloid fibers, and chaperone activity via a near-infrared aggregation-induced emission-active probe被引量：20收藏
- 作者：He, Wei Yang, Yuanyuan Qian, Yuhui Chen, Zhuoyi Zheng, Yongxin Zhao, Wenping Yan, Chenxu Guo, Zhiqian Quan, Shu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：AGGREGATE 2024
- 关键词：aggregation-induced emission fluorescence molecular chaperone protein aggregation
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- Conversion of the molecular chaperone Spy into a novel fusion tag to enhance recombinant protein expression被引量：20收藏
- 作者：Ruan, Alessandro Ren, Chang Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Protein expression Fusion tag Molecular chaperone Spy
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- The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection被引量：19收藏
- 作者：Yang, Dahai Liu, Xiaohong Xu, Wenting Gu, Zhaoyan Yang, Cuiting Zhang, Lingzhi Tan, Jinchao Zheng, Xin Wang, Zhuang Quan, Shu Zhang, Yuanxing Liu, Qin
- 机构：East China Univ Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Qingdao Natl Lab Marine Sci & Technol
- 来源：PLOS PATHOGENS 2019
- 质疑
- Novel T3SS effector EseK in Edwardsiella piscicida is chaperoned by EscH and EscS to express virulence被引量：19收藏
- 作者：Cao, Huifang Yang, Cuiting Quan, Shu Hu, Tianjian Zhang, Lingzhi Zhang, Yuanxing Yang, Dahai Liu, Qin
- 机构：East China Univ Sci & Technol;Qingdao Natl Lab Marine Sci & Technol;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：CELLULAR MICROBIOLOGY 2018
- 关键词：chaperone Edwardsiella piscicida protein-protein interaction secretion translocation virulence factor
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- Structural basis for product specificities of MLL family methyltransferases被引量：16收藏
- 作者：Li, Yanjing Zhao, Lijie Zhang, Yuebin Wu, Ping Xu, Ying Mencius, Jun Zheng, Yongxin Wang, Xiaoman Xu, Wancheng Huang, Naizhe Ye, Xianwen Lei, Ming Shi, Pan Tian, Changlin Peng, Chao Li, Guohui Liu, Zhijun Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Univ Chinese Acad Sci;Chinese Acad Sci;Chinese Acad Sci
- 来源：MOLECULAR CELL 2022
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- Exploring microbial degradation of polyamide 4 in soils: Unveiling degradation mechanisms, pathways, and the contribution of strain NR4被引量：16收藏
- 作者：Wang, Li Zhang, Ziwei Zhang, Di Qiu, Yongjun Wang, Yibing Quan, Shu Zhao, Liming
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：JOURNAL OF CLEANER PRODUCTION 2023
- 关键词：Polyamide 4 Biodegradation Soil Enrichment and acclimation PA4 degrading mechanism
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- Distinct kinetic mechanisms of H3K4 methylation catalyzed by MLL3 and MLL4 core complexes被引量：12收藏
- 作者：Zheng, Yongxin Huang, Yinping Mencius, Jun Li, Yanjing Zhao, Lijie Luo, Wanting Chen, Yong Quan, Shu
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci;ShanghaiTech Univ
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2021
- 关键词：Alkylation - Enzymes - Kinetics - Amino acids - Gene expression - Catalysis - Molecular dynamics - Peptides
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- Molecular Characterization of an Intrinsically Disordered Chaperone Reveals Net-Charge Regulation in Chaperone Action被引量：11收藏
- 作者：Ren, Chang Zheng, Yongxin Liu, Chunlan Mencius, Jun Wu, Zhili Quan, Shu
- 机构：East China Univ Sci & Technol;Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me
- 来源：JOURNAL OF MOLECULAR BIOLOGY 2022
- 关键词：chaperone intrinsically disordered protein net-charge regulation protein aggregation stress response
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- Insights into the client protein release mechanism of the ATP-independent chaperone Spy被引量：9收藏
- 作者：He, Wei Li, Xinming Xue, Hongjuan Yang, Yuanyuan Mencius, Jun Bai, Ling Zhang, Jiayin Xu, Jianhe Wu, Bin Xue, Yi Quan, Shu
- 机构：East China Univ Sci & Technol;Tsinghua Univ;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2022
- 质疑
- Attenuated substrate inhibition of a haloketone reductase via structure-guided loop engineering被引量：9收藏
- 作者：Shang, Yue-Peng Chen, Qi Li, Ai-Tao Quan, Shu Xu, Jian-He Yu, Hui-Lei
- 机构：East China Univ Sci & Technol;Hubei Univ
- 来源：JOURNAL OF BIOTECHNOLOGY 2020
- 关键词：Haloketone reductase Substrate inhibition Protein engineering X-ray crystal structure Asymmetric reduction
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- Increased surface charge in the protein chaperone Spy enhances its anti-aggregation activity被引量：7收藏
- 作者：He, Wei Zhang, Jiayin Sachsenhauser, Veronika Wang, Lili Bardwell, James C. A. Quan, Shu
- 机构：East China Univ Sci & Technol;Univ Michigan
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2020
- 关键词：molecular chaperone Spy protein engineering protein aggregation electrostatic interaction hydrophobic interaction kinetics protein folding conformational change chaperone-substrate interaction
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- Simultaneous Improvement in the Thermostability and Catalytic Activity of Epoxidase Lsd18 for the Synthesis of Lasalocid A被引量：6收藏
- 作者：Liu, Ning Xiao, Hongli Zang, Yongjian Zhou, Longji Mencius, Jun Yang, Zhiwei Quan, Shu Chen, Xi
- 机构：Northwest Univ;Xi An Jiao Tong Univ;Yunnan Normal Univ;East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
- 关键词：natural product Lsd18 thermostability FoldX Rossetta-ddG catalytic activity
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- Combinatorial metabolic engineering of Escherichia coli for de novo production of structurally defined and homogeneous Amino oligosaccharides被引量：6收藏
- 作者：Shi, Jinqi Deng, Chen Zhang, Chunyue Quan, Shu Fan, Liqiang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI;East China Univ Sci & Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2024
- 关键词：Amino oligosaccharides Chitin oligosaccharides Metabolic engineering Fed-batch cultivation bioproduction
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- Online bioinformatics teaching practice: Comparison of popular docking programs using SARS-CoV-2 spike RBD-ACE2 complex as a benchmark被引量：5收藏
- 作者：Fan, Wenxuan Mencius, Jun Du, Wenjing Fan, Huangyunxian Zhu, Hongjin Wei, Dongzhi Zhou, Mian Quan, Shu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION 2021
- 关键词：COVID-19 molecular docking protein complex SARS-CoV-2
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- 蛋白质稳定性计算设计与定向进化前沿工具被引量：5收藏
- 作者：阮青云 黄莘 孟子钧 全舒
- 机构：华东理工大学生物工程学院;上海市细胞代谢光遗传学技术前沿科学研究基地
- 来源：《合成生物学》 2023
- 关键词：蛋白质折叠 蛋白质稳定性 蛋白质稳定化工程 理性设计 计算机辅助设计 定向进化
- 摘要：天然蛋白质具有临界稳定性的特征,这种较低的稳定性使蛋白质结构具有足够的灵活性,从而支持其发挥生物学功能。然而,临界稳定性使得蛋白质遭受胁迫压力后极易发生错误折叠并失去功能,导致天然蛋白质往往无法满足科学研究与工业应用的需...
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- Fluorogenic sensing of amorphous aggregates,amyloid fibers,and chaperone activity via a near-infrared aggregation-induced emission-active probe被引量：5收藏
- 作者：Wei He Yuanyuan Yang Yuhui Qian Zhuoyi Chen Yongxin Zheng Wenping Zhao Chenxu Yan Zhiqian Guo Shu Quan
- 机构：State Key Laboratory of Bioreactor Engineering;Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering;Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism
- 来源：聚集体（英文） 2024
- 下载全文在线阅读质疑
- Chaperone-substrate interactions monitored via a robust TEM-1 β-lactamase fragment complementation assay被引量：5收藏
- 作者：Bai, Ling He, Wei Li, Tianpeng Yang, Cuiting Zhuang, Yingping Quan, Shu
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY LETTERS 2017
- 关键词：Cell envelope Chaperone Protein fragment complementation assay Protein-protein interaction Stress TEM-1 beta-lactamase
- 质疑
- FADS-Based Directed Evolution of a Robust Bst DNA Polymerase Adapting High-Temperature Loop-Mediated Isothermal Amplification (HT-LAMP)被引量：4收藏
- 作者：Li, Xiao Tang, Qiongwei Jiang, Jingjie Shang, Yuepeng Lu, Zelin Chen, Mingli He, Jiajia Liu, Feng Zhu, Sisi Zhang, Zengping Han, Hui Yu, Xixi Li, Qiuxian Xiu, Yuansong Yang, Yuhong Gui, Ping Wang, Xuefeng Lu, Feng Jing, Wei Xu, Langping Lin, Yanna Wang, Xinglong Quan, Shu Liu, Xiang Yin, Huancai Ma, Fuqiang
- 机构：Chinese Acad Sci;Yeasen Biotechnol Shanghai Co Ltd;Molefuture Biotechnol Shanghai Co Ltd;Shandong Lab Adv Biomat & Med Devices Weihai;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2025
- 关键词：FADS Bst DNA polymerase HT-LAMP strand displacement index hydrophobic blade
- 质疑
- DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates被引量：4收藏
- 作者：Zhao, Lijie Huang, Naizhe Mencius, Jun Li, Yanjing Xu, Ying Zheng, Yongxin He, Wei Li, Na Zheng, Jun Zhuang, Min Quan, Shu Chen, Yong
- 机构：Chinese Acad Sci;Univ Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;ShanghaiTech Univ
- 来源：ISCIENCE 2022
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