- Impact of Antifouling PEG Layer on the Performance of Functional Peptides in Regulating Cell Behaviors被引量：190收藏
- 作者：Chen, Qj Yu, Shan Zhang, Donghui Zhang, Wenjing Zhang, Haodong Zou, Jingcheng Mao, Zhengwei Yuan, Yuan Gao, Changyou Liu, Runhui
- 机构：East China Univ Sci & Technol;Zhejiang Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2019
- 关键词：Peptides - Chain length - Adhesives - Cells - Scaffolds (biology) - Cell engineering
- 质疑
- Surface Modified with a Host Defense Peptide-Mimicking β-Peptide Polymer Kills Bacteria on Contact with High Efficacy被引量：118收藏
- 作者：Qian, Yuxin Qi, Fan Chen, Qi Zhang, Qiang Qiao, Zhongqian Zhang, Si Wei, Ting Yu, Qian Yu, Shan Mao, Zhengwei Gao, Changyou Ding, Yiru Cheng, Yanyong Jin, Chenyu Xie, Hexin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：beta-peptide polymer graft to antimicrobial surface divalent ion membrane destabilization biocompatible surface antimicrobial resistance MRSA
- 质疑
- Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines被引量：102收藏
- 作者：Chen, Fei-Fei Zheng, Gao-Wei Liu, Lei Li, Hao Chen, Qi Li, Fu-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2018
- 关键词：amine dehydrogenase reductive amination chiral amine protein engineering biocatalysis substrate scope
- 质疑
- Dual mechanism β-amino acid polymers promoting cell adhesion被引量：92收藏
- 作者：Chen, Qi Zhang, Donghui Zhang, Wenjing Zhang, Haodong Zou, Jingcheng Chen, Mingjiao Li, Jin Yuan, Yuan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NATURE COMMUNICATIONS 2021
- 质疑
- Silk-Inspired β-Peptide Materials Resist Fouling and the Foreign-Body Response被引量：82收藏
- 作者：Zhang, Donghui Chen, Qi Zhang, Wenjing Liu, Hengjiang Wan, Jianglin Qian, Yuxin Li, Bing Tang, Songchao Liu, Yu Chen, Shengfu Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：materials science peptides polymers self-assembly surface chemistry
- 质疑
- Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1被引量：82收藏
- 作者：Zheng, Gao-Wei Liu, Yuan-Yang Chen, Qi Huang, Lei Yu, Hui-Lei Lou, Wen-Yong Li, Chun-Xiu Bai, Yun-Peng Li, Ai-Tao Xu, Jian-He
- 机构：East China Univ Sci & Technol;South China Univ Technol;Max Planck Inst Kohlenforsch
- 来源：ACS CATALYSIS 2017
- 关键词：asymmetric reduction ketoreductase chiral alcohol protein engineering substrate specificity biocatalysis
- 质疑
- A Motif-Based Deep Learning Tool for the Identification of Unusual NADH-Dependent Imine Reductases被引量：73收藏
- 作者：Shen, Xin-Yuan Wu, Yu-Xuan Ma, Zhi-Feng Yi, Xiao Shi, Min Zhu, Zhen-Yu Jin, Tian Hu, Xiao-Yu Huang, Zi-Yi Gao, Yun-Fei Chen, Qi Yu, Hui-Qun Xu, Jian-He Fan, Gui-Sheng Zheng, Gao-Wei
- 机构： State Key Laboratory of Bioreactor Engineering; School of Information Science and Engineering
- 来源：SSRN 2025
- 关键词：Amination - Enzyme immobilization - Enzyme inhibition - Enzyme kinetics - Hydrolases - Lipases
- 质疑
- Switching Cofactor Dependence of 7β-Hydroxysteroid Dehydrogenase for Cost-Effective Production of Ursodeoxycholic Acid被引量：66收藏
- 作者：You, Zhi-Neng Chen, Qi Shi, Shou-Cheng Zheng, Ming-Min Pan, Jiang Qian, Xiao-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Bioforany EnzyTech Co Ltd
- 来源：ACS CATALYSIS 2019
- 关键词：biocatalysis cofactor dependence small-and-smart library 7 beta-hydroxysteroid dehydrogenase molecular dynamics simulation ursodeoxycholic acid
- 质疑
- The impact of antifouling layers in fabricating bioactive surfaces被引量：61收藏
- 作者：Chen, Qi Zhang, Donghui Gu, Jiawei Zhang, Haodong Wu, Xue Cao, Chuntao Zhang, Xinyue Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACTA BIOMATERIALIA 2021
- 关键词：Fouling Antifouling PEG Bioactive surface Cell adhesion Functional peptides
- 质疑
- Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines被引量：54收藏
- 作者：Chen, Fei-Fei He, Xue-Feng Zhu, Xin-Xin Zhang, Zhi Shen, Xin-Yuan Chen, Qi Xu, Jian-He Turner, Nicholas J. Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Univ Manchester
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Carbonyl compounds - Nucleophiles - Substrates - Synthesis (chemical)
- 质疑
- Rational Engineering of Formate Dehydrogenase Substrate/Cofactor Affinity for Better Performance in NADPH Regeneration被引量：46收藏
- 作者：Jiang, He-Wen Chen, Qi Pan, Jiang Zheng, Gao-Wei Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2020
- 关键词：Binding affinity Burkholderia stabilis Formate dehydrogenase NADPH regeneration Rational engineering
- 质疑
- Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines被引量：44收藏
- 作者：Liu, Lei Wang, Dong-Hao Chen, Fei-Fei Zhang, Zhi-Jun Chen, Qi Xu, Jian-He Wang, Zhi-Long Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2020
- 关键词：Ammonia - Amino acids - Amines
- 质疑
- Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase被引量：41收藏
- 作者：Wang, Dong-Hao Chen, Qi Yin, Sai-Nan Ding, Xu-Wei Zheng, Yu-Cong Zhang, Zhi Zhang, Yu-Hui Chen, Fei-Fei Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2021
- 关键词：< em > reductive amination < em > < em > amine dehydrogenase < em > < em > protein engineering < em > < em > substrate scope < em > < em > chiral amine < em >
- 质疑
- Regioselectivity Engineering of Epoxide Hydrolase: Near-Perfect Enantioconvergence through a Single Site Mutation被引量：41收藏
- 作者：Li, Fu-Long Kong, Xu-Dong Chen, Qi Zheng, Yu-Cong Xu, Qin Chen, Fei-Fei Fan, Li-Qiang Lin, Guo-Qiang Zhou, Jiahai Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ
- 来源：ACS CATALYSIS 2018
- 关键词：biocatalysis epoxide hydrolase crystal structure regioselectivity enantioconvergence protein engineering
- 质疑
- Efficient Synthesis of (R)-2-Chloro-1-(2,4-dichlorophenyl)ethanol with a Ketoreductase from Scheffersomyces stipitis CBS 6045被引量：38收藏
- 作者：Shang, Yue-Peng Chen, Qi Kong, Xu-Dong Zhang, Yu-Jun Xu, Jian-He Yu, Hui-Lei
- 机构：East China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2017
- 关键词：biocatalysis bioreduction (R)-2-chloro-1-(2,4-dichlorophenyl) ethanol cofactor recycle reductase
- 质疑
- Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases被引量：35收藏
- 作者：Zhang, Yu-Hui Chen, Fei-Fei Li, Bo-Bo Zhou, Xin-Yi Chen, Qi Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2020
- 质疑
- Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox Processes with Denaturing Agents被引量：35收藏
- 作者：Qian, Wen-Zhuo Ou, Ling Li, Chun-Xiu Pan, Jiang Xu, Jian-He Chen, Qi Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：CHEMBIOCHEM 2020
- 关键词：biocatalysis chemical stability cofactor regeneration directed evolution glucose dehydrogenase
- 质疑
- De Novo Multienzyme Synthetic Pathways for Lactic Acid Production被引量：31收藏
- 作者：Ding, Xu-Wei Rong, Jing Pan, Ze-Peng Zhu, Xin-Xin Zhu, Zhen-Yu Chen, Qi Zhang, Zhi-Jun Xu, Jian-He Li, Chun-Xiu Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2024
- 关键词：biocatalysis C1 compound lacticacid multienzyme cascade protein engineering
- 质疑
- Efficient synthesis of a statin precursor in high space-time yield by a new aldehyde-tolerant aldolase identified from Lactobacillus brevis被引量：30收藏
- 作者：Jiao, Xue-Cheng Pan, Jiang Xu, Guo-Chao Kong, Xu-Dong Chen, Qi Zhang, Zhi-Jun Xu, Jian-He
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2015
- 关键词：Crystal structure - Stereochemistry - Acetaldehyde - Hydrogen bonds - Ketones - Stability - Substrates
- 质疑
- Facile Synthesis of High Molecular Weight Polypeptides via Fast and Moisture Insensitive Polymerization of α-Amino Acid N-Carboxyanhydrides被引量：28收藏
- 作者：Wu, Yue-Ming Zhang, Wei-Wei Zhou, Rui-Yi Chen, Qi Xie, Chen-Yu Xiang, Heng-Xue Sun, Bin Zhu, Mei-Fang Liu, Run-Hui
- 机构：East China Univ Sci & Technol;Donghua Univ;East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF POLYMER SCIENCE 2020
- 关键词：NCA polymerization Polypeptide Open vessel Fast polymerization HighM(w)
- 质疑
- Switching a Newly Discovered Lactonase into an Efficient and Thermostable Phosphotriesterase by Simple Double Mutations His250Ile/Ile263Trp被引量：28收藏
- 作者：Luo, Xiao-Jing Kong, Xu-Dong Zhao, Jian Chen, Qi Zhou, Jiahai Xu, Jian-He
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2014
- 关键词：organophosphate phosphotriesterase lactonase site-directed mutagenesis functional switch X-ray crystallography
- 质疑
- Engineered Imine Reductase for Larotrectinib Intermediate Manufacture被引量：28收藏
- 作者：Chen, Qi Li, Bo-Bo Zhang, Lilan Chen, Xin-Ru Zhu, Xin-Xin Chen, Fei-Fei Shi, Min Chen, Chun-Chi Yang, Yu Guo, Rey-Ting Liu, Weidong Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Hubei Univ;Chinese Acad Sci
- 来源：ACS CATALYSIS 2022
- 关键词：asymmetric reduction biocatalysis directed evolution imine reductase larotrectinib
- 质疑
- Marked enhancement of Acinetobacter sp. Organophosphorus hydrolase activity by a single residue substitution Ile211Ala被引量：27收藏
- 作者：Chen, Jie Luo, Xiao-Jing Chen, Qi Pan, Jiang Zhou, Jiahai Xu, Jian-He
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Institute of Organic Chemistry
- 来源：Bioresources and Bioprocessing 2015
- 关键词：Hydrolases
- 质疑
- Universal and One-Step Modification to Render Diverse Materials Bioactivation被引量：27收藏
- 作者：Chen, Qi Zhang, Xinyue Zhang, Donghui Liu, Guojian Ma, Ke Liu, Jingjing Ma, Kaiqian Chen, Minzhang Li, Yongsheng Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Soochow Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Adhesives - Amino acids - Molecules - Peptides - Tissue regeneration
- 质疑
- Direct reductive amination of ketones with amines by reductive aminases被引量：24收藏
- 作者：Li, Bo-Bo Zhang, Jing Chen, Fei-Fei Chen, Qi Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：GREEN SYNTHESIS AND CATALYSIS 2021
- 关键词：Biocatalysis Reductive amination Reductive aminases Protein engineering Chiral amines
- 质疑
- Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition被引量：24收藏
- 作者：Dou, Shuai Kong, Xu-Dong Ma, Bao-Di Chen, Qi Zhang, Jie Zhou, Jiahai Xu, Jian-He
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Wuhan Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2014
- 关键词：Crystal structure Pseudomonas putida esterase Enzyme-substrate complex Chiral recognition Activity enhancement Protein engineering
- 质疑
- Efficient Synthesis of 12-Oxochenodeoxycholic Acid Using a 12α-Hydroxysteroid Dehydrogenase from Rhodococcus ruber被引量：23收藏
- 作者：Shi, Shou-Cheng You, Zhi-Neng Zhou, Ke Chen, Qi Pan, Jiang Qian, Xiao-Long Xu, Jian-He Li, Chun-Xiu
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Suzhou Bioforany EnzyTech Co Ltd
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2019
- 关键词：biocatalysis 12 alpha-hydroxysteroid dehydrogenase NAD(+)-dependence structure-guided genome mining 12-oxochenodeoxycholic acid
- 质疑
- Identification two key residues at the intersection of domains of a thioether monooxygenase for improving its sulfoxidation performance被引量：22收藏
- 作者：Ren, Shi-Miao Liu, Feng Wu, Yin-Qi Chen, Qi Zhang, Zhi-jun Yu, Hui-Lei Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY AND BIOENGINEERING 2021
- 关键词：biocatalysis protein engineering (S)‐ omeprazole thioether monooxygenases
- 质疑
- Direct Reductive Amination of Biobased Furans to N-Substituted Furfurylamines by Engineered Reductive Aminase被引量：20收藏
- 作者：Yang, Zi-Yue Hao, Ya-Cheng Hu, Song-Qing Zong, Min-Hua Chen, Qi Li, Ning
- 机构：South China Univ Technol;East China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2021
- 关键词：amines biobased furans enzyme catalysis reductive aminases site-directed mutagenesis
- 质疑
- Chitooligosaccharides enhance cold tolerance by repairing photodamaged PS II in rice被引量：19收藏
- 作者：Zhou, Jiachun Chen, Qiao Zhang, Yang Fan, Liqiang Qin, Zhen Chen, Qiming Qiu, Yongjun Jiang, Lihua Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol SC
- 来源：JOURNAL OF AGRICULTURAL SCIENCE 2018
- 关键词：Chitooligosaccharides cold tolerance PS II repairing rice stress-responsive gene
- 质疑
