蔡海波 收藏
( 任职于 生物工程学院)
华东理工大学生物反应器工程国家重点实验室教授，工学博士 生物化工专业：博士生导师/硕士生导师 生物工程专业：博士生导师/硕士生导师 生物工程领域：工程硕士生导师 主要研究方向 以制备细胞治疗级效应细胞为目标，研究基于生物反应器的效应细胞规模化制备过程中的关键工程学问题。 1、研究体外培养过程中干细胞以及效应细胞的代谢特性，设计开发可满足相应细胞高效扩增的无血清培养基 2、研究体内微环境组分对干细胞体外扩增的影响及作用机制，设计研制可模拟体内微环境的生物反应器系统以及过程工艺 3、效应细胞体外规模化制备过程的建立及优化 4、细胞... 详细>>
- Myocardial regeneration: Roles of stem cells and hydrogels被引量：75收藏
- 作者：Ye, Zhaoyang Zhou, Yan Cai, Haibo Tan, Wensong
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED DRUG DELIVERY REVIEWS 2011
- 关键词：Myocardial regeneration Cell therapy Tissue engineering Stem cells Hydrogels
- 质疑
- Heparin-immobilized polymers as non-inflammatory and non-thrombogenic coating materials for arsenic trioxide eluting stents被引量：72收藏
- 作者：Gong, Feirong Cheng, Xiaoyan Wang, Shanfeng Zhao, Yanchao Gao, Yun Cai, Haibo
- 机构：Univ Tennessee;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ACTA BIOMATERIALIA 2010
- 关键词：Stent Biodegradability Heparin Arsenic trioxide (As2O3) Restenosis
- 质疑
- An Antifouling and Antimicrobial Zwitterionic Nanocomposite Hydrogel Dressing for Enhanced Wound Healing被引量：67收藏
- 作者：Dai, Zhaobo Zhang, Yuanhao Chen, Chao Yu, Fan Tian, Jia Cai, Haibo Jiang, Xiaoze Zhang, Liangshun Zhang, Weian
- 机构：East China Univ Sci & Technol;Donghua Univ
- 来源：ACS BIOMATERIALS SCIENCE & ENGINEERING 2021
- 关键词：antifouling antimicrobial hydrogel wound healing
- 质疑
- Porphyrin-containing amphiphilic block copolymers for photodynamic therapy被引量：64收藏
- 作者：Xu, Lei Liu, Lichao Liu, Feng Cai, Haibo Zhang, Weian
- 机构：E China Univ Sci & Technol
- 来源：POLYMER CHEMISTRY 2015
- 关键词：Photosensitizers - Porphyrins - Monomers - Photodynamic therapy - Living polymerization - Micelles
- 质疑
- Progress in the microbial production of S-adenosyl-L-methionine被引量：60收藏
- 作者：Chen, Hailong Wang, Zhilai Cai, Haibo Zhou, Changlin
- 机构：China Pharmaceut Univ;East China Univ Sci & Technol
- 来源：WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY 2016
- 关键词：S-Adenosyl-L-methionine Microbial production Conventional strain breeding Mutant screening Fermentation process Metabolic engineering
- 质疑
- Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins被引量：60收藏
- 作者：Liu, Renmei Yang, Jing Yao, Jing Zhao, Zhou He, Wei Su, Ni Zhang, Zeyi Zhang, Chenxia Zhang, Zhuo Cai, Haibo Zhu, Linyong Zhao, Yuzheng Quan, Shu Chen, Xianjun Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE BIOTECHNOLOGY 2022
- 关键词：Proteins - Cell culture
- 质疑
- Pillar[5]arene-Based Acid-Triggered Supramolecular Porphyrin Photosensitizer for Combating Bacterial Infections and Biofilm Dispersion被引量：55收藏
- 作者：Xia, Lei Tian, Jia Yue, Tao Cao, Hongliang Chu, Ju Cai, Haibo Zhang, Weian
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED HEALTHCARE MATERIALS 2022
- 关键词：antibacterial photodynamic arene porphyrin supramolecular
- 质疑
- Comparison between the effects of normoxia and hypoxia on antioxidant enzymes and glutathione redox state in ex vivo culture of CD34+ cells被引量：50收藏
- 作者：Fan, Jinli Cai, Haibo Yang, Shi Yan, Lingli Tan, WenSong
- 机构：E China Univ Sci & Technol
- 来源：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY 2008
- 关键词：CD34+hematopoietic stem and progenitor cells (HSPCs) glutathione hypoxia normoxia oxidative stress
- 质疑
- Role of the plasma membrane ROS-generating NADPH oxidase in CD34+ progenitor cells preservation by hypoxia被引量：49收藏
- 作者：Fan, Jinli Cai, Haibo Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2007
- 关键词：CD34(+) hematopoietic stem and progenitor cells (HSPCs) hypoxia ex vivo expansion reactive oxygen species (ROS) cord blood NADPH oxidase
- 质疑
- Porous chitosan derivative scaffolds affect proliferation and osteogenesis of mesenchymal stem cell via reducing intracellular ROS被引量：44收藏
- 作者：Wang, Jin Zhou, Lehao Sun, Qihao Cai, Haibo Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Carbohydrate Polymers 2020
- 关键词：Biocompatibility - Bone - Cell culture - Defects - Flowcharting - Physicochemical properties - Scaffolds (biology) - Stem cells
- 质疑
- The effects of ROS-mediating oxygen tension on human CD34+CD38- cells induced into mature dendritic cells被引量：44收藏
- 作者：Fan, Jinli Cai, Haibo Li, Qunliang Du, Zheng Tan, Wensong
- 机构： State Key Laboratory of Bioreactor Engineering; School of Chemistry and Chemical Engineering; Shanghai Clinical Research Center
- 来源：Journal of Biotechnology 2012
- 关键词：Amino acids - Cytology - Stem cells - Cell membranes - Oxygen - Gene expression
- 质疑
- Photocontrollable release and enhancement of photodynamic therapy based on host-guest supramolecular amphiphiles被引量：42收藏
- 作者：Xu, Lei Zhang, Wenyan Cai, Haibo Liu, Feng Wang, Yong Gao, Yun Zhang, Weian
- 机构：E China Univ Sci & Technol;Nanjing Tech Univ
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2015
- 关键词：Amphiphiles - Irradiation - Micelles - Cell culture - Efficiency - Supramolecular chemistry - Photosensitizers
- 质疑
- Polyvinyl alcohol, N-acetylcysteine, and methyl-β-cyclodextrin exhibit albumin functions in natural killer cell culture被引量：40收藏
- 作者：Xu, Ruisheng Zhang, Guofeng Huang, Huimin Zhao, Yuanyuan Tan, Wen-Song Cai, Haibo
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Bioscience and Bioengineering 2025
- 关键词：Animal cell culture - Body fluids - Fatty acid methyl ester - Mitochondria - Plant cell culture - Reactive oxygen species
- 质疑
- RETRACTED: Porous chitosan derivative scaffolds affect proliferation and osteogenesis of mesenchymal stem cell via reducing intracellular ROS (Retracted article. See vol. 373, 2026)被引量：39收藏
- 作者：Wang, Jin Zhou, Lehao Sun, Qihao Cai, Haibo Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：CARBOHYDRATE POLYMERS 2020
- 关键词：Mesenchymal stem cell Chitosan Reactive oxygen species Osteogenic differentiation
- 质疑
- Cultivation of aquaculture feed Isochrysis zhangjiangensis in low-cost wave driven floating photobioreactor without aeration device被引量：38收藏
- 作者：Zhu, Chenba Han, Desen Li, Yonghai Zhai, Xiaoqian Chi, Zhanyou Zhao, Yunpeng Cai, Haibo
- 机构：Dalian Univ Technol;East China Univ Sci & Technol;Dalian Univ Technol
- 来源：BIORESOURCE TECHNOLOGY 2019
- 关键词：Floating photobioreactor Aquaculture Isochrysis zhangjiangensis Microalgae
- 质疑
- Role of the plasma membrane ROS-generating NADPH oxidase in CD34+ progenitor cells preservation by hypoxia被引量：35收藏
- 作者：Fan, Jinli Cai, Haibo Tan, Wen-Song
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Journal of Biotechnology 2007
- 关键词：Blood - Cell culture - Cell membranes - Phosphates - RNA - Scavenging
- 质疑
- Potent antitumor effect of TRAIL mediated by a novel adeno-associated viral vector targeting to telomerase activity for human hepatocellular carcinoma被引量：29收藏
- 作者：Wang, Yigang Huang, Fang Cai, Haibo Zhong, Suyang Liu, Xinyuan Tan, Wen-Song
- 机构：E China Univ Sci & Technol;Zheijiang Sci Tech Univ;Chinese Acad Sci
- 来源：JOURNAL OF GENE MEDICINE 2008
- 关键词：adeno-associated virus hTERT promoter TRAIL antitumor efficacy
- 质疑
- Hematopoietic reconstitution of CD34+ cells derived from short-term cultured cord blood mononuclear cells被引量：27收藏
- 作者：Yang, Shi Cai, Haibo Jin, Huili Fan, Jinli Tan, Wen-Song
- 机构： The State Key Laboratory of Bioreactor Engineering
- 来源：Biotechnology and Bioprocess Engineering 2009
- 关键词：Blood - Cytology - Stem cells - Mammals
- 质疑
- The efficacy of combination therapy using adeno-associated virus-TRAIL targeting to telomerase activity and cisplatin in a mice model of hepatocellular carcinoma被引量：24收藏
- 作者：Wang, Yigang Huang, Fang Cai, Haibo Wu, Yumei He, Guoqing Tan, Wen-Song
- 机构：E China Univ Sci & Technol;Zhejiang Sci Tech Univ
- 来源：JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2010
- 关键词：TRAIL Cisplatin Hepatocellular carcinoma Adeno-associated virus HTERT promoter Antitumor efficacy
- 质疑
- POSS-enhanced thermosensitive hybrid hydrogels for cell adhesion and detachment被引量：22收藏
- 作者：Tong, Yudong Zhang, Yuanhao Liu, Yangyang Cai, Haibo Zhang, Weian Tan, Wen-Song
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2018
- 关键词：Irradiation - Cell culture - Crosslinking - Acrylic monomers - Amides - Cell proliferation - Cell adhesion - Cell engineering - Stem cells - Biomechanics
- 质疑
- Encapsulated feeder cells within alginate beads for ex vivo expansion of cord blood-derived CD34+ cells被引量：18收藏
- 作者：Pan, Xiuwei Sun, Qiong Cai, Haibo Gao, Yun Tan, Wensong Zhang, Weian
- 机构：East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2016
- 关键词：Stem cells - Alginate - Feeding - Expansion
- 质疑
- One-pot synthesis of well-defined amphiphilic alternating copolymer brushes based on POSS and their self-assembly in aqueous solution被引量：18收藏
- 作者：Zhang, Zhenghe Hong, Lizhi Li, Jinxia Liu, Feng Cai, Haibo Gao, Yun Zhang, Weian
- 机构：E China Univ Sci & Technol
- 来源：RSC ADVANCES 2015
- 关键词：Polydispersity - Polyethylene oxides - Polyethylenes - Solutions - Thermodynamic properties - Dynamic light scattering - Living polymerization - High resolution transmission electron microscopy - Thermogravimetric analysis - Differential scanning calorimetry - Free radical polymerization - Self assembly
- 质疑
- A chemically defined, mechanically tunable, and bioactive hyaluronic acid/ alginate double-network hydrogel for liver cancer organoid construction被引量：17收藏
- 作者：Zhao, Yuanyuan Gong, Junjie Liu, Hanwen Huang, Huimin Tan, Wen-song Cai, Haibo
- 机构：East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2024
- 关键词：Liver cancer organoid Double-network hydrogel Hyaluronic acid Cell adhesion Drug efficacy evaluation
- 质疑
- Sustained release of epigallocatechin-3-gallate from chitosan-based scaffolds to promote osteogenesis of mesenchymal stem cell被引量：17收藏
- 作者：Wang, Jin Sun, Qihao Wei, Yin Hao, Mengyang Tan, Wen-Song Cai, Haibo
- 机构：East China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2021
- 关键词：Epigallocatechin-3-gallate Chitosan nanoparticles Scaffolds Osteogenesis
- 质疑
- 高分子量透明质酸的发酵研究被引量：16收藏
- 作者：田毅红 蔡海波 陆仕灿 谭文松 许建和
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《中国医药工业杂志》 2004
- 关键词：透明质酸 分批补料发酵 兽疫链球菌
- 摘要：采用兽疫链球菌(Streptococcus zooepidemicus)进行分批补料发酵生产透明质酸(HA)。结果表明:采用葡萄糖初始浓度为4%,分批补加葡萄糖,使其浓度控制在2%,可使HA的产量达到3.4g/L,平均分...
- 下载全文在线阅读质疑
- 不同培养条件下CIK细胞纯度变化的研究被引量：16收藏
- 作者：康自珍 蔡海波 徐莉 谭文松
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《免疫学杂志》 2001
- 关键词：CIK细胞 纯度 脐血 成人外周血 细胞培养
- 摘要：目的为了研究不同培养条件对 CIK细胞 ( cytokine- induced killer cells,CIK细胞 )纯度的影响。方法分别从脐血和成人外周血单个核细胞定向诱导 CIK细胞的产生 ,用流式细胞分析法对不同...
- 下载全文在线阅读质疑
- Optimization of SCF feeding regimen for ex vivo expansion of cord blood hematopoietic stem cells被引量：14收藏
- 作者：Du, Zheng Cai, Haibo Ye, Zhaoyang Tan, Wen-Song
- 机构：E China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2013
- 关键词：Hematopoietic stem cells Cord blood Stem cell factor Ex vivo expansion Feeding regimen
- 质疑
- Optimizing Conditions of Polyethylene Glycol Precipitation for Exosomes Isolation From MSCs Culture Media for Regenerative Treatment被引量：14收藏
- 作者：Yu, Junjun Huang, Daqiang Liu, Hanwen Cai, Haibo
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2024
- 关键词：exosomes miRNAs polyethylene glycol proteins
- 质疑
- The antimicrobial activity of Cbf-K16 against MRSA was enhanced by β-lactamantibiotics through cell wall non-integrity被引量：14收藏
- 作者：Li, Bo Kang, Wei Liu, Hanhan Wang, Yanrong Yu, Changzhong Zhu, Xinyi Dou, Jie Cai, Haibo Zhou, Changlin
- 机构：China Pharmaceut Univ;East China Univ Sci & Technol
- 来源：ARCHIVES OF PHARMACAL RESEARCH 2016
- 关键词：Cbf-K-16 Antimicrobial activity Ceftazidime Ampicillin MRSA Synergistic effect
- 质疑
- Promoted Proliferation of Hematopoietic Stem Cells Enabled by a Hyaluronic Acid/Carbon Nanotubes Antioxidant Hydrogel被引量：13收藏
- 作者：Zhang, Yuanhao Tong, Yudong Pan, Xiuwei Cai, Haibo Gao, Yun Zhang, Weian
- 机构：East China Univ Sci & Technol
- 来源：MACROMOLECULAR MATERIALS AND ENGINEERING 2019
- 关键词：antioxidant hydrogels carbon nanotubes hematopoietic stem cells reactive oxygen species
- 质疑
