吴君臣 收藏
( 任职于 化学与分子工程学院)
吴君臣，男，博士，副教授，硕士生导师。 近年来一直从事超分子生物化学研究工作已发表了18篇SCI论文，主要发表在J. Am. Chem. Soc，Angew. Chem. Int. Ed, Org. Lett, Chem. Commun, Chem. Eur. J等杂志上。 研究兴趣和方向： （1）多肽抗肿瘤药物； （2）基于多肽类的各种生物酶的抑制剂； （3）生物大分子的组装与识别。 ... 详细>>
- Peptide self-assembly triggered by metal ions被引量：258收藏
- 作者：Zou, Rongfeng Wang, Qi Wu, Junchen Wu, Jingxian Schmuck, Carsten Tian, He
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Nantong Univ;Univ Duisburg Essen
- 来源：CHEMICAL SOCIETY REVIEWS 2015
- 质疑
- A Molecular Peptide Beacon for the Ratiometric Sensing of Nucleic Acids被引量：140收藏
- 作者：Wu, Junchen Zou, Ying Li, Chunyan Sicking, Wilhelm Piantanida, Ivo Yi, Tao Schmuck, Carsten
- 机构：Fudan Univ;E China Univ Sci & Technol;E China Univ Sci & Technol;Rudjer Boskovic Inst;Univ Duisburg Essen
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2012
- 关键词：Peptides
- 质疑
- A Dual-Modality Photoswitchable Supramolecular Polymer被引量：109收藏
- 作者：Zhang, Qiwei Qu, Da-Hui Wu, Junchen Ma, Xiang Wang, Qiaochun Tian, He
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：LANGMUIR 2013
- 关键词：Functional polymers - Functional materials
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- A switchable peptide sensor for real-time lysosomal tracking被引量：61收藏
- 作者：Chen, Lei Wu, Junchen Schmuck, Carsten Tian, He
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ Duisburg Essen
- 来源：CHEMICAL COMMUNICATIONS 2014
- 质疑
- Alkyl-triphenylamine end-capped triazines with AIE and large two-photon absorption cross-sections for bioimaging被引量：54收藏
- 作者：Gao, Yuting Qu, Yi Jiang, Tao Zhang, Hao He, Nannan Li, Bo Wu, Junchen Hua, Jianli
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Fudan Univ;Fudan Univ;E China Normal Univ
- 来源：JOURNAL OF MATERIALS CHEMISTRY C 2014
- 关键词：Fluorophores - Lanthanum compounds - Chlorine compounds - Photons - Two photon processes
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- A new triphenylamine fluorescent dye for sensing of cyanide anion in living cell被引量：53收藏
- 作者：Qu, Yi Jin, Bin Liu, Yi Wu, Yongquan Yang, Lin Wu, Junchen Hua, Jianli
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：TETRAHEDRON LETTERS 2013
- 关键词：Cyanide anion Fluorescent sensor Triphenylamine-pyridine Living cell
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- Two-component organogel for visually detecting nitrite anion被引量：46收藏
- 作者：Xia, Qian Mao, Yueyuan Wu, Junchen Shu, Tianmin Yi, Tao
- 机构：Fudan Univ;Fudan Univ;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY C 2014
- 关键词：Naphthalene - Scanning electron microscopy - X ray diffraction - Solutions - Negative ions - Gelation
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- Near-Infrared Fluorogenic Probes with Polarity-Sensitive Emission for in Vivo Imaging of an Ovarian Cancer Biomarker被引量：45收藏
- 作者：Yao, Defan Lin, Zhi Wu, Junchen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Peking Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2016
- 关键词：lysophosphatidic acid biomarker polarity-sensitive near-infrared probe
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- Recent advances in peptide nucleic acid for cancer bionanotechnology被引量：38收藏
- 作者：Wu, Jun-chen Meng, Qing-chun Ren, Hong-mei Wang, Hong-tao Wu, Jie Wang, Qi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;PetroChina Huabei Oilfield Co;Nantong Univ
- 来源：ACTA PHARMACOLOGICA SINICA 2017
- 关键词：peptide nucleic acids bionanotechnology cancer diagnostics and therapy
- 质疑
- Activity of Antimicrobial Peptide Aggregates Decreases with Increased Cell Membrane Embedding Free Energy Cost被引量：31收藏
- 作者：Zou, Rongfeng Zhu, Xiaomin Tu, Yaoquan Wu, Junchen Landry, Markita P.
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KTH Royal Inst Technol;Univ Calif Berkeley;Chan Zuckerberg Biohub
- 来源：BIOCHEMISTRY 2018
- 关键词：Bioactivity - Gibbs free energy - Antibiotics - Cytology - Hydrogen bonds - Molecular dynamics - Bacteria - Free energy
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- A fluorescent probe for imaging hydrogen peroxide in ovarian cancer cells被引量：30收藏
- 作者：Zhao, Peng Wang, Kunyan Zhu, Xiaomin Zhou, Yuren Wu, Junchen
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2018
- 关键词：Hydrogen peroxide Fluorescence probe Ovarian cancer cells
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- Magainin II modified polydiacetylene micelles for cancer therapy被引量：29收藏
- 作者：Yang, Danling Zou, Rongfeng Zhu, Yu Liu, Ben Yao, Defan Jiang, Juanjuan Wu, Junchen Tian, He
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：NANOSCALE 2014
- 关键词：Cancer cells - Tumors - Drug delivery - Diseases - Energy transfer - Fluorescence - Liposomes - Acetylene - Cell culture - Cells
- 质疑
- Tumor-cell targeting polydiacetylene micelles encapsulated with an antitumor drug for the treatment of ovarian cancer被引量：29收藏
- 作者：Yao, Defan Li, Shang Zhu, Xiaomin Wu, Junchen Tian, He
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2017
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- Free Energy Profile and Kinetics of Coupled Folding and Binding of the Intrinsically Disordered Protein p53 with MDM2被引量：26收藏
- 作者：Zou, Rongfeng Zhou, Yang Wang, Yong Kuang, Guanglin Agren, Hans Wu, Junchen Tu, Yaoquan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;KTH Royal Inst Technol;Univ Copenhagen;Henan Univ
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2020
- 关键词：Free energy - Binding energy - Proteins
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- A FRET-enabled molecular peptide beacon with a significant red shift for the ratiometric detection of nucleic acids被引量：22收藏
- 作者：Maity, Debabrata Jiang, Juanjuan Ehlers, Martin Wu, Junchen Schmuck, Carsten
- 机构：Univ Duisburg Essen;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2016
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- Cholesterol-directed nanoparticle assemblies based on single amino acid peptide mutations activate cellular uptake and decrease tumor volume被引量：22收藏
- 作者：Li, Shang Zou, Rongfeng Tu, Yaoquan Wu, Junchen Landry, Markita P.
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Calif Berkeley;Univ Calif Berkeley;KTH Royal Inst Technol
- 来源：CHEMICAL SCIENCE 2017
- 关键词：Drug delivery - Van der Waals forces - Cancer cells - Cell death - Nanoparticles - Cholesterol - Diagnosis - Molecular biology - Amino acids - Diseases - Tumors
- 质疑
- A supramolecular peptide polymer from hydrogen-bond and coordination-driven self-assembly被引量：21收藏
- 作者：Zhu, Xiaomin Zou, Rongfeng Sun, Peng Wang, Qi Wu, Junchen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Royal Inst Technol KTH;Chinese Acad Sci;Nantong Univ
- 来源：POLYMER CHEMISTRY 2018
- 关键词：Dichroism - Fluorescence spectroscopy - Fourier transform infrared spectroscopy - Viscosity measurement - Drug delivery - Light scattering - Scanning electron microscopy - Dimethyl sulfoxide - High resolution transmission electron microscopy - Peptides - Atomic force microscopy - Positive ions - Circular dichroism spectroscopy - Nuclear magnetic resonance spectroscopy - Hydrogen bonds
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- Real-time near-infrared bioimaging of a receptor-targeted cytotoxic dendritic theranostic agent被引量：18收藏
- 作者：Wu, Junchen Zhou, Yuren Li, Shang Qu, Dahui Zhu, Wei-Hong Tian, He
- 机构：East China Univ Sci & Technol; East China Univ Sci & Technol
- 来源：BIOMATERIALS 2017
- 关键词：Substance P 5-fluorouracil Neurokinin-1 receptor Near-infrared imaging Anticancer
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- A peptide probe for the detection of neurokinin-1 receptor by disaggregation enhanced fluorescence and magnetic resonance signals被引量：15收藏
- 作者：Wu, Jingxian Zou, Rongfeng Wang, Qi Xue, Yajing Wei, Ping Yang, Shiping Wu, Junchen Tian, He
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Nantong Univ;Nantong Tumor Hosp;Fudan Univ
- 来源：SCIENTIFIC REPORTS 2014
- 质疑
- Peptide-Based Probes with an Artificial Anion-Binding Motif for Direct Fluorescence "Switch-On" Detection of Nucleic Acid in Cells被引量：13收藏
- 作者：Maity, Debabrata Matkovic, Marija Li, Shang Ehlers, Martin Wu, Junchen Piantanida, Ivo Schmuck, Carsten
- 机构：Univ Duisburg Essen;Rudjer Boskovic Inst;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2017
- 关键词：anion receptors cell imaging DNA detection fluorescent probe molecular recognition
- 质疑
- Synthesis and Antibacterial Activities of Antibacterial Peptides with a Spiropyran Fluorescence Probe被引量：10收藏
- 作者：Chen, Lei Zhu, Yu Yang, Danling Zou, Rongfeng Wu, Junchen Tian, He
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：SCIENTIFIC REPORTS 2014
- 质疑
- An effective peptide cargo carrier for the delivery of cisplatin in ovarian cancer cells被引量：9收藏
- 作者：Lai, Yanhua Zhao, Ping Zhang, Zhan Li, Bai Wu, Junchen
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Changhai Hosp
- 来源：DYES AND PIGMENTS 2017
- 关键词：Peptide cargo carrier Targeted delivery Cisplatin Ovarian cancer Disassembly
- 质疑
- A fluorescent light-up probe as an inhibitor of intracellular β-tryptase被引量：8收藏
- 作者：Wang, Qi Shi, Xiuyin Zhu, Xiaoxia Ehlers, Martin Wu, Junchen Schmuck, Carsten
- 机构：Nantong Univ;Nantong Univ;Univ Duisburg Essen;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2014
- 质疑
- A crosslinked colloidal network of peptide/nucleic base amphiphiles for targeted cancer cell encapsulation被引量：6收藏
- 作者：Zhou, Yanzi Qiu, Peng Yao, Defan Song, Yanyan Zhu, Yuedong Pan, Haiting Wu, Junchen Zhang, Junji
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CHEMICAL SCIENCE 2021
- 关键词：Biocompatibility - Cells - Diseases - Cytology - Amphiphiles - Peptides
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- In Vivo Detoxification of Lipopolysaccharide by Antimicrobial Peptides被引量：5收藏
- 作者：Zhang, Wenxu He, Jiangcheng Wu, Junchen Schmuck, Carsten
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Duisburg Essen
- 来源：BIOCONJUGATE CHEMISTRY 2017
- 关键词：Cell membranes - Peptides - Bacteria
- 质疑
- 小分子肽类传感器在重大疾病中的诊断被引量：0收藏
- 作者：吴君臣 田禾
- 机构：华东理工大学精细化工研究所
- 来源：《中国化学会第28届学术年会》 2012
- 关键词：多肽 核酸 传感器
- 摘要：生物活性肽是蛋白质中25 个天然氨基酸以不同组成和排列方式构成的从二肽到复杂的线性、环形结构的不同肽类的总称，是源于蛋白质的多功能化合物.活性肽具有多种人体代谢和生理调节功能，易消化吸收，有促进免疫、激素调节、抗菌、抗病...
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- 一种硝基还原酶探针的合成与研究被引量：0收藏
- 作者：黄微 吴君臣
- 机构：华东理工大学化学与分子工程学院
- 来源：《中国科技论文》 2018
- 关键词：生物化学 荧光探针 硝基还原酶 RGD环肽 肿瘤
- 摘要：硝基还原酶(nitroreductase,NTR)通常在缺氧肿瘤细胞中过表达,其含量与细胞缺氧程度直接相关,因此有效检测NTR对肿瘤的诊断显得尤为重要。本研究设计合成了一种将环状精氨酸-甘氨酸-天冬氨酸(cRGD)与小分...
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- 一种β-折叠肽的合成及其对tau蛋白聚集的抑制被引量：0收藏
- 作者：赵朋 王坤艳 吴君臣
- 机构：华东理工大学化学与分子工程学院
- 来源：《中国科技论文》 2018
- 关键词：生物化学 淀粉样蛋白聚集 阿尔茨海默氏病 肽抑制剂
- 摘要：淀粉样蛋白聚集物与阿尔茨海默氏病、帕金森氏病和Ⅱ型糖尿病等许多疾病的密切相关。为抑制tau蛋白聚集,设计并合成了一种大环β-折叠肽抑制剂。通过紫外光谱、荧光光谱测定了其光谱性质;通过硫代黄素ThS荧光法研究了其对tau蛋...
- 下载全文在线阅读质疑
- Peptide-based Hydrogel Responses to Alkali and Transition Metal Ions被引量：0收藏
- 作者：Rongfeng Zou Yu Zhu Danling Yang Junchen Wu
- 机构：Key Lab for Advanced Materials and Institute of Fine Chemicals Institution
- 来源：[1]Key Lab for Advanced Materials and Institute of Fine Chemicals Institution,East China University of Science and Technology,Meilong Road 130,Shanghai 200237,China; 2014
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