成果/Result
- Risk assessment of antibiotic resistance genes in the drinking water system被引量：104收藏
- 作者：Hu, Yaru Jiang, Lei Sun, Xiaoyan Wu, Jianqiang Ma, Lei Zhou, Yanbo Lin, Kuangfei Luo, Yi Cui, Changzheng
- 机构：East China Univ Sci & Technol;Shanghai Inst Pollut Control & Ecol Secur;Natl Engn Res Ctr Urban Water Resources;East China Univ Sci & Technol;Shanghai Acad Environm Sci
- 来源：SCIENCE OF THE TOTAL ENVIRONMENT 2021
- 关键词：Antibiotic resistance genes Chlorine-resistant Drinking water system Resistance risk ranking in drinking water system ((RDW)-D-3) Risk assessment Trace level antibiotics
- Thiamine hydrochloride as a efficient catalyst for the synthesis of amidoalkyl naphthols被引量：89收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON LETTERS 2009
- A convenient one-pot synthesis of formamide derivatives using thiamine hydrochloride as a novel catalyst被引量：83收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON LETTERS 2010
- Potential AMPK activators of cucurbitane triterpenoids from Siraitia grosvenorii Swingle被引量：66收藏
- 作者：Chen, Xu-bing Zhuang, Jing-jing Liu, Jun-hua Lei, Min Ma, Lei Chen, Jing Shen, Xu Hu, Li-hong
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：BIOORGANIC & MEDICINAL CHEMISTRY 2011
- 关键词：Siraitia grosvenorii Swingle Cucurbitane triterpenoids AMPK HepG2 cell Anti-diabetic effect
- Occurrence, distribution, and seasonal variation of antibiotics in an artificial water source reservoir in the Yangtze River delta, East China被引量：64收藏
- 作者：Cui, Changzheng Han, Qi Jiang, Lei Ma, Lei Jin, Lei Zhang, Dong Lin, Kuangfei Zhang, Tianyang
- 机构：East China Univ Sci & Technol;Natl Engn Res Ctr Urban Water Resources;East China Univ Sci & Technol
- 来源：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2018
- 关键词：Antibiotics Variation Risk assessment Artificial water source reservoir
- Post-transcriptional regulation of the tumor suppressor miR-139-5p and a network of miR-139-5p-mediated mRNA interactions in colorectal cancer被引量：60收藏
- 作者：Shen, Ke Mao, Rurong Ma, Li Li, Yueqi Qiu, Yanyan Cui, Daling Le, Vanminh Yin, Peihao Ni, Lei Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Shanghai Jiao Tong Univ
- 来源：FEBS JOURNAL 2014
- 关键词：3'-UTR colorectal cancer (CRC) competing endogenous RNA (ceRNA) miR-139-5p post-transcriptional regulation
- A green, efficient, and rapid procedure for the synthesis of 2-amino-3-cyano-1,4,5,6-tetrahydropyrano[3,2-c]quinolin-5-one derivatives catalyzed by ammonium acetate被引量：55收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Shanghai Inst Mat Med
- 来源：TETRAHEDRON LETTERS 2011
- 关键词：Green chemistry Multi-component reaction 4-Hydroxyquinolin-2(1H)-one Aldehyde Malononitrile
- Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits被引量：49收藏
- 作者：Ma, Li Mao, Rurong Shen, Ke Zheng, Yuanhong Li, Yueqi Liu, Jianwen Ni, Lei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2014
- 关键词：Gastric cancer Cancer stem cells Atractylenolide I Notch CD44
- An efficient and environmentally friendly procedure for synthesis of pyrimidinone derivatives by use of a Biginelli-type reaction被引量：49收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：MONATSHEFTE FUR CHEMIE 2010
- 关键词：Multicomponent reactions Aldehyde Organocatalyst Green chemistry
- FeCl3 and morpholine as efficient cocatalysts for the one-step synthesis of quinoxalines from α-hydroxyketones and 1,2-diamines被引量：47收藏
- 作者：Liu, Peng Lei, Min You, Hanyun Chen, Xubing Chen, Hu Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2012
- 关键词：Chlorine compounds - Conversion efficiency - Hydrogen bonds - Ketones
- Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents被引量：44收藏
- 作者：Yang, Gui-Xiang Huang, Yan Zheng, Lu-Lu Zhang, Li Su, Lin Wu, Yu-Hang Li, Jie Zhou, Li-Cheng Huang, Jin Tang, Yun Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2020
- 关键词：Alzheimer's disease Diosgenin Antioxidant Anti-inflammatory Anti-A beta activity Multi-target-directed ligands
- Design, synthesis and biological evaluation of chalcones as reversers of P-glycoprotein-mediated multidrug resistance被引量：43收藏
- 作者：Yin, Huanhuan Dong, Jingjing Cai, Yingchun Shi, Ximeng Wang, Hao Liu, Guixia Tang, Yun Liu, Jianwen Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2019
- 关键词：Chalcones P-glycoprotein inhibitors Structure-activity relationship Multidrug resistance reversers Inhibitors docking
- 3D skin models along with skin-on-a-chip systems: A critical review被引量：41收藏
- 作者：Sun, Wenxuan Liu, Zijia Xu, Jian Cheng, Ya Yin, Ruixue Ma, Lei Li, Honglin Qian, Xuhong Zhang, Hongbo
- 机构：East China Univ Sci & Technol;East China Normal Univ;East China Univ Sci & Technol;East China Normal Univ
- 来源：CHINESE CHEMICAL LETTERS 2023
- 关键词：3D skin model Skin equivalent Skin-on-a-chip 3D bioprinting Skin barrier
- Thiamine Hydrochloride-Catalyzed One-Pot Synthesis of 1,4-Dihydropyridine Derivatives Under Solvent-Free Conditions被引量：41收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2011
- 关键词：Aldehydes 1 4-dihydropyridines Hantzsch reaction -keto ester thiamine hydrochloride (VB1)
- One-pot synthesis of 1 H-benzimidazole derivatives using thiamine hydrochloride as a reusable organocatalyst被引量：39收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构： Shanghai Research Center for Modernization of Traditional Chinese Medicine; School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2012
- 关键词：Aldehydes - Aromatic compounds - Dimethylformamide - Metal ions - Metal recovery
- Investigation of the immunosuppressive activity of Physalin H on T lymphocytes被引量：38收藏
- 作者：Yu, Youjun Sun, Lijuan Ma, Lei Li, Jiyu Hu, Lihong Liu, Jianwen
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：INTERNATIONAL IMMUNOPHARMACOLOGY 2010
- 关键词：Physalin H Immunosuppressive Cell mitosis cycle Delayed-type hypersensitivity Th1/Th2 balance Heme oxygenase-1
- Discovery of Inhibitors To Block Interactions of HIV-1 Integrase with Human LedGF/p75 via Structure-Based Virtual Screening and Bioassays被引量：37收藏
- 作者：Hu, Guoping Li, Xi Zhang, Xuan Li, Yaozong Ma, Lei Yang, Liu-Meng Liu, Guixia Li, Weihua Huang, Jin Shen, Xu Hu, Lihong Zheng, Yong-Tang Tang, Yun
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci
- 来源：JOURNAL OF MEDICINAL CHEMISTRY 2012
- Sarsasapogenin-AA13 ameliorates Aβ-induced cognitive deficits via improving neuroglial capacity on Aβ clearance and antiinflammation被引量：37收藏
- 作者：Huang, Cui Dong, Dong Jiao, Qian Pan, Hui Ma, Lei Wang, Rui
- 机构：East China Univ Sci & Technol
- 来源：CNS NEUROSCIENCE & THERAPEUTICS 2017
- 关键词：antiinflammation beta-amyloid clearance neuroglia phagocytosis sarsasapogenin-AA13
- ONE-POT SYNTHESIS OF 1H-BENZIMIDAZOLE DERIVATIVES USING THIAMINE HYDROCHLORIDE AS A REUSABLE ORGANOCATALYST被引量：36收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2012
- 关键词：Aldehyde 1H-benzimidazole green chemistry o-phenylenediamine thiamine hydrochloride (VB1)
- HIGHLY CHEMOSELECTIVE CONDENSATION OF β-NAPHTHOL, ALDEHYDE, AND UREA CATALYZed BY THIAMINE HYDROCHLORIDE被引量：35收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHETIC COMMUNICATIONS 2011
- 关键词：Catalysis chemoselective multicomponent reactions (MCRs) beta-naphthol thiamine hydrochloride (VB1)
- Design, synthesis, and biological evaluation of diosgenin-indole derivatives as dual-functional agents for the treatment of Alzheimer's disease被引量：34收藏
- 作者：Zhou, Li-Cheng Liang, Ying-Fan Huang, Yi Yang, Gui-Xiang Zheng, Lu-Lu Sun, Jia-Min Li, Yang Zhu, Fu-Li Qian, He-Wen Wang, Rui Ma, Lei
- 机构：East China Univ Sci & Technol
- 来源：EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2021
- 关键词：Diosgenin Antioxidant Anti-beta amyloid Alzheimer's disease
- Development of a method for trace level determination of antibiotics in drinking water sources by high performance liquid chromatography-tandem mass spectrometry被引量：33收藏
- 作者：Cheng, Wenhuan Jiang, Lei Lu, Ning Ma, Lei Sun, Xiaoyan Luo, Yi Lin, Kuangfei Cui, Changzheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Natl Engn Res Ctr Urban Water Resources;Naikai Univ
- 来源：ANALYTICAL METHODS 2015
- 关键词：Extraction - Phase separation - Mass spectrometry - High performance liquid chromatography - Potable water - Trace analysis - Water quality
- Metabolic pathway for degradation of anthracene by halophilic Martelella sp AD-3被引量：33收藏
- 作者：Cui, Changzheng Ma, Lei Shi, Jie Lin, Kuangfei Luo, Qishi Liu, Yongdi
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Acad Environm Sci
- 来源：INTERNATIONAL BIODETERIORATION & BIODEGRADATION 2014
- 关键词：Anthracene Biodegradation Moderate halophilic bacteria Metabolic pathway 3-Hydroxy-2-naphthoic acid
- A facile protocol for the synthesis of 4-aryl-1,4,7,8-tetrahydro-3,5- dimethyldipyrazolo[3,4-b:4′,3′-e]pyridine derivatives by a Hantzsch-type reaction被引量：32收藏
- 作者：Zhao, Kun Lei, Min Ma, Lei Hu, Lihong
- 机构： Shanghai Research Center for Modernization of Traditional Chinese Medicine; School of Pharmacy
- 来源：Monatshefte fur Chemie 2011
- 关键词：Catalysts - Condensation reactions - Environmental impact - Pyridine - Synthesis (chemical)
- Cu(ClO4)2.6H2O as an efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones under solvent-free conditions被引量：32收藏
- 作者：Lei, Min Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2011
- 关键词：Urea
- HClO4-SiO2 as an efficient and recyclable catalyst for the synthesis of amide derivatives被引量：31收藏
- 作者：Song, Weibin Ma, Lei Hu, Lihong
- 机构： School of Pharmacy; Shanghai Institute of Materia Medica
- 来源：Synthetic Communications 2011
- 关键词：Alkylation - Catalysts - Chlorine compounds - Condensation - Silica - Sulfur compounds
- Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1)被引量：31收藏
- 作者：Ma, Lei Yang, Zhengyi Li, Chenjing Zhu, Zhiyuan Shen, Xu Hu, Lihong
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2011
- 关键词：Alzheimer's disease BACE1 chalcone SAR Glycyrrhiza uralensis
- Immunosuppression effect of Withangulatin A from Physalis angulata via heme oxygenase 1-dependent pathways被引量：30收藏
- 作者：Sun, Lijuan Liu, Jianwen Liu, Ping Yu, Youjun Ma, Lei Hu, Lihong
- 机构： State Key Laboratory of Bioreactor Engineering; LongHua Hospital; Shanghai Innovative Research Center of Traditional Chinese Medicine
- 来源：Process Biochemistry 2011
- 关键词：Porphyrins
- Immunosuppressive Withanollides from Withania coagulans被引量：29收藏
- 作者：Huang, Chao-Feng Ma, Lei Sun, Li-Juan Ali, Mumtaz Arfan, Mohammad Liu, Jian-Wen Hu, Li-Hong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci;Univ Peshawar
- 来源：CHEMISTRY & BIODIVERSITY 2009
- Sarsasapogenin-AA13 inhibits LPS-induced inflammatory responses in macrophage cells in vitro and relieves dimethylbenzene-induced ear edema in mice被引量：29收藏
- 作者：Dong, Dong Zhou, Nan-nan Liu, Rui-xuan Xiong, Jia-wei Pan, Hui Sun, Si-qi Ma, Lei Wang, Rui
- 机构：East China Univ Sci & Technol
- 来源：ACTA PHARMACOLOGICA SINICA 2017
- 关键词：sarsasapogenin AA13 antifani anti-inflammation inflammatory factor nuclear factor-kappa B mitogen-activated protein kinases ear edema
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