成果/Result
- Poly(2-Oxazoline)-Based Functional Peptide Mimics: Eradicating MRSA Infections and Persisters while Alleviating Antimicrobial Resistance被引量：229收藏
- 作者：Zhou, Min Qian, Yuxin Xie, Jiayang Zhang, Wenjing Jiang, Weinan Xiao, Ximian Chen, Sheng Dai, Chengzhi Cong, Zihao Ji, Zhemin Shao, Ning Liu, Longqiang Wu, Yuequn Liu, Runhui
- 机构：East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：antibiotics antimicrobials drug design peptides polymers
- Mit1 Transcription Factor Mediates Methanol Signaling and Regulates the Alcohol Oxidase 1 (AOX1) Promoter in Pichia pastoris被引量：95收藏
- 作者：Wang, Xiaolong Wang, Qi Wang, Jinjia Bai, Peng Shi, Lei Shen, Wei Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing Cai, Menghao
- 机构：E China Univ Sci & Technol;SCICB
- 来源：JOURNAL OF BIOLOGICAL CHEMISTRY 2016
- 关键词：DNA-protEIn interaction protEIn domain signal transduction transcription coactivator transcription regulation AOX1 promoter Mit1 Pichia pastoris glycerol repression methanol induction
- Host defense peptide mimicking poly--peptides with fast, potent and broad spectrum antibacterial activities被引量：94收藏
- 作者：Zhang, Qiang Ma, Pengcheng Xie, Jiayang Zhang, Si Xiao, Ximian Qiao, Zhongqian Shao, Ning Zhou, Min Zhang, Wenjing Dai, Chengzhi Qian, Yuxin Qi, Fan Liu, Runhui
- 机构：East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2019
- 关键词：Antibiotics - Bacteria - Mammals - Antimicrobial agents - Network security
- Short Guanidinium-Functionalized Poly(2-oxazoline)s Displaying Potent Therapeutic Efficacy on Drug-Resistant Fungal Infections被引量：84收藏
- 作者：Jiang, Weinan Zhou, Min Cong, Zihao Xie, Jiayang Zhang, Wenjing Chen, Sheng Zou, Jingcheng Ji, Zhemin Shao, Ning Chen, Xin Li, Maoquan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2022
- 关键词：Antifungal Polymers Drug-Resistant Fungi Guanidinium-Pendent Peptidomimetics Poly(2-oxazoline)s
- Practical Preparation of Infection-Resistant Biomedical Surfaces from Antimicrobial β-Peptide Polymers被引量：83收藏
- 作者：Qi, Fan Qian, Yuxin Shao, Ning Zhou, Ruiyi Zhang, Si Lu, Ziyi Zhou, Min Xie, Jiayang Wei, Ting Yu, Qian Liu, Runhui
- 机构：East China Univ Sci & Technol;Soochow Univ
- 来源：ACS APPLIED MATERIALS & INTERFACES 2019
- 关键词：beta-peptide polymer host defense peptide antimicrobial surface MRSA subcutaneous infection
- Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance被引量：67收藏
- 作者：Shao, Ning Yuan, Ling Ma, Pengcheng Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Xiao, Guohui Fei, Jian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Diseases - Biocompatibility - Cancer cells - Tumors
- Water-Insensitive Synthesis of Poly-β-Peptides with Defined Architecture被引量：66收藏
- 作者：Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Zhang, Wenjing Ma, Pengcheng Chen, Sheng Zhang, Haodong Zhang, Danfeng Zhang, Donghui Luan, Xiangfeng Mai, Yiyong Liu, Runhui
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：polymerization poly-beta-peptides secondary structure water-insensitive polymerization beta-NTA
- Microbial Metabolite Inspired β-Peptide Polymers Displaying Potent and Selective Antifungal Activity被引量：41收藏
- 作者：Zhang, Donghui Shi, Chao Cong, Zihao Chen, Qi Bi, Yufang Zhang, Junyu Ma, Kaiqian Liu, Shiqi Gu, Jiawei Chen, Minzhang Lu, Ziyi Zhang, Haodong Xie, Jiayang Xiao, Ximian Liu, Longqiang Jiang, Weinan Shao, Ning Chen, Sheng Zhou, Min Shao, Xiaoyan Dai, Yidong Li, Maoquan Zhang, Lixin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Ruijin Rehabil Hosp;Tongji Univ
- 来源：ADVANCED SCIENCE 2022
- 关键词：antifungal agents fungal keratitis host defense peptide mimicking poly(DL-diaminopropionic acid) beta-peptide polymers
- PpNrg1 is a transcriptional repressor for glucose and glycerol repression of AOX1 promoter in methylotrophic yeast Pichia pastoris被引量：38收藏
- 作者：Wang, Xiaolong Cai, Menghao Shi, Lei Wang, Qi Zhu, Jinxiang Wang, Jinjia Zhou, Mian Zhou, Xiangshan Zhang, Yuanxing
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg
- 来源：BIOTECHNOLOGY LETTERS 2016
- 关键词：AOX1 promoter Catabolite repression Glucose Glycerol PpNrg1 Pichia pastoris Transcriptional regulation
- Breaking or following the membrane-targeting mechanism: Exploring the antibacterial mechanism of host defense peptide mimicking poly(2-oxazoline)s被引量：36收藏
- 作者：Dai, Chengzhi Zhou, Min Jiang, Weinan Xiao, Ximian Zou, Jingcheng Qian, Yuxin Cong, Zihao Ji, Zhemin Liu, Longqiang Xie, Jiayang Qiao, Zhongqian Liu, Runhui
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2020
- 关键词：Poly(2-oxazoline) Host defense peptide Antibacterial mechanism Membrane-targeting Antimicrobial resistance
- Fabrication of viable and functional pre-vascularized modular bone tissues by coculturing MSCs and HUVECs on microcarriers in spinner flasks被引量：30收藏
- 作者：Zhang, Songjie Zhou, Min Ye, Zhaoyang Zhou, Yan Tan, Wen-Song
- 机构：East China Univ Sci & Technol
- 来源：BIOTECHNOLOGY JOURNAL 2017
- 关键词：Bone tissue engineering Endothelial cells Mesenchymal stem cells Microcarriers Vascularization
- Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin被引量：23收藏
- 作者：Zhang, Wenjing Wu, Yueming Chen, Qi Zhang, Haodong Zhou, Min Chen, Kang Cao, Chuntao Guo, Han Xu, Jianrong Liu, Honglai Lin, Haodong Liu, Changsheng Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2022
- 关键词：fibronectin mimicking growth factor binding statistic copolymers
- Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture被引量：19收藏
- 作者：Ma, Pengcheng Wu, Yueming Jiang, Weinan Shao, Ning Zhou, Min Chen, Yuan Xie, Jiayang Qiao, Zhongqian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2022
- 关键词：Antibiotics - Aquaculture - Bacteria - Biodegradable polymers - Disease control
- De novo biosynthesis of 2′-fucosyllactose in engineered Pichia pastoris被引量：18收藏
- 作者：Qian, Difan Zhang, Chunyue Deng, Chen Zhou, Mian Fan, Liqiang Zhao, Liming
- 机构：East China Univ Sci & Technol;Shanghai Changzheng Hosp;Shanghai Collaborat Innovat Ctr Biomfg Technol SCI
- 来源：BIOTECHNOLOGY LETTERS 2023
- 关键词：Biosynthesis 2 '-Fucosyllactose Human milk oligosaccharides Pichia pastoris
- Strong negative correlation between codon usage bias and protEIn structural disorder impedes protEIn expression after codon optimization被引量：13收藏
- 作者：Liu, Kunshan Ouyang, Yaqi Lin, Ru Ge, Chenyu Zhou, Mian
- 机构：East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2022
- 关键词：Codon usage bias Codon optimization ProtEIn expression Pichia pastoris
- Peptide-mimicking poly(2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria被引量：12收藏
- 作者：Cong, Zihao Yan, Zi Xiao, Ximian Liu, Longqiang Luo, Zhengjie Zou, Jingcheng Chen, Minzhang Wu, Yueming Zhou, Min Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2025
- 关键词：Poly(2-oxazoline)s Host defense peptide Antibiofilm MRSA Drug-resistance
- Host defense peptide mimicking cyclic peptoid polymers exerting strong activity against drug-resistant bacteria被引量：12收藏
- 作者：Zhang, Wenjing Deng, Shuai Zhou, Min Zou, Jingcheng Xie, Jiayang Xiao, Ximian Yuan, Ling Ji, Zhemin Chen, Sheng Cui, Ruxin Luo, Zhengjie Xia, Guixue Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2022
- 关键词：Amino acids - Bacteria - Network security
- Alter codon bias of the P. pastoris genome to overcome a bottleneck in codon optimization strategy development and improve protEIn expression被引量：11收藏
- 作者：Zhang, Siyu Lin, Ru Cui, Luyao Jiang, Tianyi Shi, Jiacheng Li, Pengfei Zhou, Mian
- 机构：East China Univ Sci & Technol;China Innovat Ctr Roche
- 来源：MICROBIOLOGICAL RESEARCH 2024
- 关键词：Codon optimization Pichia pastoris ProtEIn expression Chassis cells
- Enzymatic synthesis of pharmacologically relevant chiral sulfoxides by improved CbBVMO variants被引量：8收藏
- 作者：Zhao, Chen Liu, Feng Zhou, Min Geng, Qiang Yu, Hui-Lei
- 机构：East China Univ Sci & Technol
- 来源：CHEMICAL COMMUNICATIONS 2023
- Self-Assembled Poly(sarcosine) Functionalized Host Defense Peptide-Mimicking Poly-β-Peptides for Combating Drug-Resistant Fungal Infection被引量：7收藏
- 作者：Xie, Jiayang Liu, Zhefeng Zhou, Min Luo, Zhengjie Liu, Longqiang Xiao, Ximian Jiang, Weinan Hu, Weilong Wu, Yueming Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ADVANCED FUNCTIONAL MATERIALS 2025
- 关键词：antifungal host defense peptide mimic poly(sarcosine) functionalized poly-beta-peptides self-assembly
- PiggyBac transposon-mediated mutagenesis and application in yeast Komagataella phaffii被引量：7收藏
- 作者：Zhu, Jinxiang Zhu, Qiaoyun Gong, Ruiqing Xu, Qin Cai, Menghao Jiang, Tianyi Zhou, Xiangshan Zhou, Mian Zhang, Yuanxing
- 机构：East China Univ Sci & Technol;SCICB;Roche R&D Ctr China Ltd
- 来源：BIOTECHNOLOGY LETTERS 2018
- 关键词：Mutagenesis Komagataella phaffii piggyBac Transposon
- Controlled copolymerization of α-NCAs and α-NNTAs for preparing peptide/peptoid hybrid polymers with adjustable proteolysis被引量：7收藏
- 作者：Zou, Jingcheng Zhou, Min Ji, Zhemin Xiao, Ximian Wu, Yueming Cui, Ruxin Deng, Shuai Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：POLYMER CHEMISTRY 2022
- 关键词：Amino acids - Biocompatibility - Copolymerization - Proteolysis - Synthesis (chemical)
- Phosphorylation of PppA at threonine 253 controls T6SS2 expression and bacterial killing capacity in the marine pathogen Vibrio alginolyticus被引量：6收藏
- 作者：Yang, Zhen Wang, Xuetong Xu, Wensheng Zhou, Mian Zhang, Yuanxing Ma, Yue Wang, Qiyao
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg;Shanghai Engn Res Ctr Maricultured Anim Vaccines;Beijing Univ Agr
- 来源：MICROBIOLOGICAL RESEARCH 2018
- 关键词：T6SS2 Vibrio alginolyticus PppA QS Bacterial killing
- Advance in Hybrid Peptides Synthesis被引量：5收藏
- 作者：Zou, Jingcheng Zhou, Min Xiao, Ximian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：MACROMOLECULAR RAPID COMMUNICATIONS 2022
- 关键词：hybrid peptides alpha/beta-peptides peptide/peptoid hybrids polymerization solid-phase synthesis
- Synthesis and antimicrobial applications of α-peptoid polymers被引量：5收藏
- 作者：Xie, Jiayang Hu, Weilong Feng, Xi Liu, Zixin Zhou, Min Liu, Runhui
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMICAL SCIENCE 2025
- 关键词：Antibiotics - Health risks - Microorganisms - Nitrogen - Proteolysis - Public health
- Host Defense Peptide-Mimicking Poly(2-oxazoline)s Displaying Potent Activities toward Phytopathogens to Alleviate Antimicrobial Resistance in Agriculture被引量：4收藏
- 作者：Chen, Sheng Zhou, Min Xiao, Ximian Xie, Jiayang Liu, Longqiang Cong, Zihao Zhao, Xuebin Hu, Weilong Wang, Jie Song, Gonghua Liu, Runhui
- 机构：East China Univ Sci & Technol;China Railway Acad Grp Co Ltd;China Railway Cultural Heritage Rehabil Technol In;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2025
- 关键词：host defense peptides poly(2-oxazoline)s phytopathogens antimicrobial resistance
- Controllable and facile synthesis of poly(2-oxazoline)s using trimethylsilyl trifluoromethanesulfonate as the initiator被引量：4收藏
- 作者：Zhou, Min Ji, Zhemin Xiao, Ximian Liu, Longqiang Cui, Ruxin Luo, Zhengjie Cong, Zihao Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：POLYMER CHEMISTRY 2023
- 关键词：Biocompatibility - Block copolymers
- An effective approach to obtain functional poly-β-peptides for combating drug-resistant bacterial infections被引量：1收藏
- 作者：Chen, Sheng Luo, Zhengjie Zhou, Min Xiao, Ximian Cong, Zihao Xie, Jiayang Wu, Yueming Zhang, Haodong Zhao, Xuebin Song, Gonghua Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Shanghai Shyndec Pharmaceut Co Ltd
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2025
- 关键词：Chain length
- Effective combinatorial antifungal therapy using a host defense peptide mimic that self-assembles into delivery micelles被引量：0收藏
- 作者：Liu, Longqiang Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Xie, Jiayang Zhang, Qiang Zhang, Junyu Jiang, Weinan Liu, Runhui
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：NATURE BIOTECHNOLOGY 2026
- 关键词：Antifungal agents - Controlled drug delivery - Diseases - Fungi - Fungicides - Peptides - Targeted drug delivery
