成果/Result
- Surface Modified with a Host Defense Peptide-Mimicking β-Peptide Polymer Kills Bacteria on Contact with High Efficacy被引量：118收藏
- 作者：Qian, Yuxin Qi, Fan Chen, Qi Zhang, Qiang Qiao, Zhongqian Zhang, Si Wei, Ting Yu, Qian Yu, Shan Mao, Zhengwei Gao, Changyou Ding, Yiru Cheng, Yanyong Jin, Chenyu Xie, Hexin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2018
- 关键词：beta-peptide polymer graft to antimicrobial surface divalent ion membrane destabilization biocompatible surface antimicrobial resistance MRSA
- Detection of Carbapenemase-Producing Organisms with a Carbapenem-Based Fluorogenic Probe被引量：68收藏
- 作者：Mao, Wuyu Xia, Lingying Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：antibiotic resistance carbapenemases fluorescent probes beta-lactamases
- In Vivo Visualization of γ-Glutamyl Transpeptidase Activity with an Activatable Self-Immobilizing Near-Infrared Probe被引量：56收藏
- 作者：Li, Yuyao Xue, Chenghong Fang, Zhijun Xu, Weipan Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2020
- 关键词：Mammals - Quinone - Enzyme activity - Probes - Cytology - Infrared devices
- A self-immobilizing near-infrared fluorogenic probe for sensitive imaging of extracellular enzyme activity in vivo被引量：54收藏
- 作者：Li, Yuyao Song, Heng Xue, Chenghong Fang, Zhijun Xiong, Liqin Xie, Hexin
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Infrared devices - Quinone - Enzyme activity - Probes
- Synthesis of Aldehydes by Organocatalytic Formylation Reactions of Boronic Acids with Glyoxylic Acid被引量：49收藏
- 作者：Huang, He Yu, Chenguang Li, Xiangmin Zhang, Yongqiang Zhang, Yueteng Chen, Xiaobei Mariano, Patrick S. Xie, Hexin Wang, Wei
- 机构：Univ New Mexico;East China Univ Sci Technol;East China Univ Sci Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2017
- 关键词：arenes boron formylation organocatalysis synthetic methods
- A Self-Immobilizing and Fluorogenic Probe for -Lactamase Detection被引量：47收藏
- 作者：Mao, Wuyu Xia, Lingying Wang, Yaqun Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2016
- 关键词：antibiotic resistance enzymes fluorescent probes immobilization -lactamase
- Ligand-free Cu-catalyzed [3+2] cyclization for the synthesis of pyrrolo[1,2-a]quinolines with ambient air as a terminal oxidant被引量：47收藏
- 作者：Yu, Yang Liu, Yuan Liu, Aoxia Xie, Hexin Li, Hao Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2016
- 关键词：Catalysis - Chelation - Ligands - Oxidants
- A Br?nsted acid-promoted asymmetric intramolecular allylic amination of alcohols被引量：46收藏
- 作者：Zhou, Jianqiao Xie, Hexin
- 机构： State Key Laboratory of Bioreactor Engineering
- 来源：Organic and Biomolecular Chemistry 2018
- A novel method combining aptamer-Ag10NPs based microfluidic biochip with bright field imaging for detection of KPC-2-expressing bacteria被引量：30收藏
- 作者：Chen, Jing Li, Hui Xie, Hexin Xu, Danke
- 机构：Nanjing Univ;East China Univ Sci & Technol
- 来源：ANALYTICA CHIMICA ACTA 2020
- 关键词：Bacteria Microfluidic chip Bright field Aptamer Nanoparticle
- Enzyme-Activatable Near-Infrared Photosensitizer with High Enrichment in Tumor Cells Based on a Multi-Effect Design被引量：27收藏
- 作者：Li, Yuyao Zhang, Chaoying Wu, Qingyi Peng, Yan Ding, Yiru Zhang, Zhengwei Xu, Xiaoyong Xie, Hexin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2024
- 关键词：Enzyme-Activatable Fluorescence Probe Photosensitizer Quinone Methide Tumor
- Pretargeted Multimodal Tumor Imaging by Enzymatic Self-Immobilization Labeling and Bioorthogonal Reaction被引量：27收藏
- 作者：Miao, Yinxing Wang, Yuqi Chen, Yefeng Huang, Zheng Lu, Chunmei Liu, Yili Chen, Fangfang Wen, Xidan Zhang, Junya Zhu, Shiliang Zhao, Pengke Chen, Yunhan Tian, Tian Zhang, Yan Xie, Hexin Lin, Jianguo Ye, Deju
- 机构：Nanjing Univ;East China Univ Sci & Technol;Jiangsu Inst Nucl Med
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2025
- 关键词：Cell immobilization - Cell membranes - Enzyme immobilization - Nafion membranes
- Organocatalytic asymmetric addition of alcohols to cyclic trifluoromethyl ketimines: highly enantioselective synthesis of chiral N,O-ketals被引量：19收藏
- 作者：Zhou, Ding Yu, Xueting Zhang, Jian Wang, Wei Xie, Hexin
- 机构：East China Univ Sci & Technol;Univ New Mexico
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2016
- 关键词：Positive ions
- Highly Efficient Multiple-Labeling Probes for the Visualization of Enzyme Activities被引量：17收藏
- 作者：Song, Heng Li, Yuyao Chen, Yefeng Xue, Chenghong Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2019
- 关键词：alkaline phosphatase enzyme activity imaging immobilization quinone methide
- A minor structure modification serendipitously leads to a highly carbapenemase-specific fluorogenic probe被引量：15收藏
- 作者：Wang, Jie Xu, Weipan Xue, Shuyuan Yu, Tao Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2020
- 关键词：Amino acids - Carbon
- Specific detection of IMP-1 β-lactamase activity using a trans cephalosporin-based fluorogenic probe被引量：13收藏
- 作者：Hu, Liqiang Liu, Runqiu Ma, Zheng Yu, Tao Li, Ziyao Zou, Yingqiu Yuan, Chang Chen, Fangfang Xie, Hexin
- 机构：East China Univ Sci & Technol;Shanghai Soong Ching Ling Sch
- 来源：CHEMICAL COMMUNICATIONS 2021
- 关键词：Amino acids - Probes
- Screening aptamers for serine β-lactamase-expressing bacteria with Precision-SELEX被引量：10收藏
- 作者：Yu, Fang Chen, Jing Wang, Zecheng Yang, Huixin Li, Hui Jia, Wenchao Xue, Shuyuan Xie, Hexin Xu, Danke
- 机构：Nanjing Univ;East China Univ Sci & Technol
- 来源：TALANTA 2021
- 关键词：Aptamers Precision-SELEX Bacteria High-content imaging Nanoparticle
- Copper-mediated direct thiolation of aryl C-H bonds with disulfides被引量：7收藏
- 作者：Deng, Ke-Zuan Zhang, Li-Li Chen, Ye-Feng Xie, He-Xin Xu, Xiao-Bo Xia, Cheng-Cai Ji, Ya-Fei
- 机构：East China Univ Sci & Technol;Shanghai Synmedia Chem Co Ltd;Shandong First Med Univ & Shandong Acad Med Sci
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2019
- 关键词：Amides - Sulfur compounds - Additives
- Highly Sensitive In Vivo Imaging of Bacterial Infections with a Hydrophilicity-Switching, Self-Immobilizing, Near-Infrared Fluorogenic β-Lactamase Probe Enriched within Bacteria被引量：6收藏
- 作者：Chen, Fangfang Li, Yuyao Peng, Yan Zhu, Yifan He, Gao Zhang, Zhengwei Xie, Hexin
- 机构：East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：ADVANCED SCIENCE 2025
- 关键词：beta-lactamases antibiotic resistance bacterial infections fluorescence probes in vivo imaging
- Enhancing the antibacterial efficacy of vancomycin analogues: targeting metallo-β-lactamases and cell wall biosynthesis被引量：6收藏
- 作者：Sarkar, Paramita Xu, Weipan Vazquez-Hernandez, Melissa Dhanda, Geetika Tripathi, Shubhandra Basak, Debajyoti Xie, Hexin Schipp, Lea Dietze, Pascal Bandow, Julia E. Nair, Nishanth N. Haldar, Jayanta
- 机构：Jawaharlal Nehru Ctr Adv Sci Res;East China Univ Sci & Technol;Ruhr Univ Bochum;Indian Inst Technol Kanpur;Jawaharlal Nehru Ctr Adv Sci Res
- 来源：CHEMICAL SCIENCE 2024
- 关键词：Bioactivity - Cell membranes
- Amine-Catalyzed Highly Regioselective and Stereoselective C(sp2)-C(sp2) Cross-Coupling of Naphthols with trans-,-Unsaturated Aldehydes被引量：6收藏
- 作者：Hu, Yang Ma, Yueyue Sun, Rengwei Yu, Xinhong Xie, Hexin Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2015
- 关键词：cascade reaction cross-coupling metal-free organocatalysis -naphtholylation
- Arylamino-substituted Rhodamine as a Fluorogenic Molecular Rotor for the Wash-free Imaging of Non-catalytic ProtEIns in Live Cells被引量：2收藏
- 作者：Tang, Huiling Yuan, Xia Chen, Yefeng Li, Yuyao Xu, Xiaoyong Xie, Hexin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ANALYSIS & SENSING 2024
- 关键词：live cell imaging molecular rotor protEIn integrin alpha(v)beta(3)
- A "One-to-Multi" Activatable Near-infrared Fluorescent Probe for the Sensitive Imaging of γ-Glutamyl Transpeptidase Activity in Living Mice被引量：1收藏
- 作者：Ding, Yiru Chen, Youyan Dou, Huanke Zhang, Zhengwei Xie, Hexin
- 机构：East China Univ Sci & Technol;Fudan Univ;Fudan Univ
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2025
- 关键词：Fluorescent probe In vivo imaging Quinone methide gamma-glutamyl transpeptidase
- Sensitive detection and labelling of protEIns with a molecular rotor-based fluorogenic probe被引量：1收藏
- 作者：Chen, Na Wu, Qingyi Yuan, Xia Xie, Hexin
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC & BIOMOLECULAR CHEMISTRY 2025
- Enzyme-Triggered Self-Immobilization of an NIR Prodrug for Tumor-Selective Cancer Vaccination被引量：0收藏
- 作者：Li, Yuyao Ren, Hongze Feng, Jiayi Shan, Xiaochuan Zhang, Chaoying Nan, Jin Tang, Zhengqi Ding, Xueqin Yu, Meihua Xie, Hexin Chen, Yu
- 机构：Shanghai Univ;Nantong Univ;East China Univ Sci & Technol;Fudan Univ;Shanghai Inst Materdicine
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2026
- 关键词：Antigens - Cell death - Cell immobilization - Chemical activation - Diseases - Pathology - Tumors - Vaccines
- A Versatile Synthetic Strategy Enables the Discovery of Regioisomer-Dependent in Vivo Performance in Self-Immobilizing Hemicyanine Dyes被引量：0收藏
- 作者：Ding, Yiru Dou, Huanke Zhang, Chaoying Wang, Ruoxuan Mu, Xin Li, Yuyao Xie, Hexin
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Univ
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2026
- 关键词：in vivo imaging NIR fluorophore quinone methide self-immobilization Synthesis
- 肾小球滤过率活体实时监测荧光示踪剂的研究进展被引量：0收藏
- 作者：丁奕如 张超颖 谢贺新
- 机构：华东理工大学药学院
- 来源：《高等学校化学学报》 2022
- 关键词：肾小球滤过率 荧光示踪剂 实时监测 急性肾损伤
- 摘要：急性肾损伤是一种临床常见的急性疾病.通过外源性的荧光示踪剂对肾小球滤过率进行非侵入性的实时监测,对于及时了解易患病人的肾脏功能具有重要的临床价值和应用前景.本文综合评述了用于活体检测肾小球滤过率的外源性荧光示踪剂的近期研...
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