- Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl -Fluorinated gem-Diols to N-Benzyl Isatins被引量：96收藏
- 作者：Saidalimu, Ibrayim Fang, Xiang He, Xiao-Peng Liang, Jing Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2013
- 关键词：aldol reaction carboncarbon bond cleavage organocatalysis reaction mechanisms trifluoroacetate release
- 质疑
- AIBN-initiated radical addition of gem-difluorinated alkyl iodides to alkynes and the Pd-catalyzed Sonogashira coupling reaction of E-phenyl difluoromethylene vinylic iodides with terminal alkynes被引量：54收藏
- 作者：Fang, Xiang Yang, Xueyan Yang, Xianjin Mao, Shenjie Wang, Zhonghua Chen, Guorong Wu, Fanhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2007
- 关键词：alkynes radical addition difluoromethylene vinylic iodides sonogashira coupling
- 质疑
- Exploiting Distal Reactivity of Coumarins: A Rhodium-Catalyzed Vinylogous Asymmetric Ring-Opening Reaction被引量：45收藏
- 作者：Loh, Charles C. J. Schmid, Matthias Peters, Brendan Fang, Xiang Lautens, Mark
- 机构：Univ Toronto;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2016
- 关键词：enantioselectivity heterocycles ring-opening reactions rhodium synthetic methods
- 质疑
- Organocatalytic Asymmetric Michael Addition/Carbon-Carbon Bond Cleavage of Trifluoromethyl α-Fluorinated gem-Diols to Nitroolefins被引量：39收藏
- 作者：Saidalimu, Ibrayim Fang, Xiang Lv, Wenwen Yang, Xueyan He, Xiaopeng Zhang, Jingyuan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2013
- 关键词：asymmetric Michael addition carbon-carbon bond cleavage thiourea catalysts trifluoroacetate release trifluoromethyl -fluorinated gem-diols
- 质疑
- Benzylic Functionalization of Anthrones via the Asymmetric Ring Opening of Oxabicycles Utilizing a Fourth-Generation Rhodium Catalytic System被引量：25收藏
- 作者：Loh, Charles C. J. Fang, Xiang Peters, Brendan Lautens, Mark
- 机构：Univ Toronto;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2015
- 关键词：asymmetric catalysis dearomatization oxabicycles rhodium ring opening reactions
- 质疑
- New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite被引量：19收藏
- 作者：Yang, Xueyan Fang, Xiang Yang, Xianjin Zhao, Min Han, Yizheng Shen, Yongjia Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2008
- 关键词：difluoroiodomethylsulfanylbenzene difluoromethylene gamma-butyrolactone addition tetrahydrofuran derivatives
- 质疑
- Synthesis of difluoromethylene-containing 1,2,4-oxadiazole compounds via the reaction of 5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole with unsaturated compounds initiated by sodium dithionite被引量：18收藏
- 作者：Yang, Xueyan Wang, Zhonghua Fang, Xiang Yang, Xianjin Wu, Fanhong Shen, Yongjia
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHESIS-STUTTGART 2007
- 关键词：difluoromethylene 1,2,4-oxadiazole gamma-butyrolactone addition cyclization
- 质疑
- Synthesis of γ,γ-difluoro-β-hydroxy-δ-lactones as new precursors of HMG-CoA reductase inhibitor被引量：11收藏
- 作者：Wang, Xiaoguang Fang, Xiang Xiao, Hongyuan Yin, Yan Xia, Huimin Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2012
- 关键词：Statin HMG-CoA reductase inhibitor Precursor gamma,gamma-Difluoro-beta-hydroxy-delta-lactones
- 质疑
- Synthesis of fluoroalkyl-δ-lactones from polyfluoroalkyl iodides and 5-hexenoic acids被引量：11收藏
- 作者：Fang, Xiang Ying, Qi Chen, Yang Yang, Xueyan Yang, Xianjin Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2008
- 关键词：5-hexenoic acids polyfluoroalkyl iodide delta-valerolactone sodium dithionite polyfluoroalkyl-lactonization
- 质疑
- A new and direct route to 3-fluoromethyl substituted pyrazol-4-acrylates via Pd-catalyzed C-H activation被引量：10收藏
- 作者：Wang, Xiaoguang Fang, Xiang Xiao, Hongyuan Gong, Dongming Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON 2013
- 关键词：3-Fluoromethyl pyrazoles Pd-catalyzed C4-H activation Benzoquinone Concerted metalation-deprotonation (CMD)
- 质疑
- Microwave-assisted expeditious synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones被引量：9收藏
- 作者：Yang, Bo Shi, Luyan Wu, JingJing Fang, Xiang Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON 2013
- 关键词：2-Oxazolidin-2-ones Free radical addition One-pot reaction Microwave irradiation Fluoroalkyl iodide
- 质疑
- Synthesis and substitution reactions of β-alkoxyvinyl bromodifluoromethyl ketones被引量：9收藏
- 作者：Fang, Xiang Chen, Yang He, Doming Yang, Xianjin Wu, Fanhong
- 机构：Chinese Acad Sci;E China Univ Sci & Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2008
- 关键词：Fluorinated synthons beta-Alkoxyvinyl bromodifluoromethyl ketones Enaminones
- 质疑
- Facile synthesis of 2-fluoroindenones via a Knoevenagel condensation/palladium-catalyzed annulation被引量：9收藏
- 作者：Su, Yue Fang, Xiang Zhou, Jun Bian, Yizhen Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2018
- 关键词：2-Fluoroindenones Domino reaction Knoevenagel condensation Intramolecular heck cyclization
- 质疑
- Highly stereoselective monofluoroolefination: Facile access to (E)-α-fluorinated arylvinyl sulfones from trifluoromethyl α-fluorinated arylsulfonyl gem-diols被引量：7收藏
- 作者：Fang, Xiang Zhou, Jun Wang, Wang Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON LETTERS 2020
- 关键词：Monofluoroolefination Stereoselective Trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols alpha-Fluorinated arylvinyl sulfones
- 质疑
- I2/TBHP-Promoted Approach to α-Keto Esters from Trifluoromethyl β-Diketones and Alcohols via C-C Bond Cleavage被引量：7收藏
- 作者：Shao, Tongle Fang, Xiang Zhou, Jun Jin, Chen Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：SYNLETT 2017
- 关键词：trifluoromethyl beta-diketones alpha-keto esters C-C bond cleavage C-O coupling alcohols
- 质疑
- Construction of N-Boc monofluoromethyl aryl sulfones via Mannich reaction of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols被引量：6收藏
- 作者：Wang, Wang Fang, Xiang Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2020
- 关键词：Mannich reaction Nucleophilic monofluoromethylation Trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols Detrifluoroacetylation
- 质疑
- One-Pot Synthesis of α-Fluoroketones and 3-Fluoro-2,4-diarylfurans from Trifluoromethyl β-Diketones via Decarboxylation被引量：6收藏
- 作者：Shao, Tongle Fang, Xiang Yang, Xueyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ Toronto
- 来源：SYNLETT 2015
- 关键词：fluorine alpha-fluoroketones 3-fluorofurans one-pot decarboxylation
- 质疑
- Synthesis of 1,3,5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate]pyrazoles via a Pd-Catalyzed C-H Activation被引量：6收藏
- 作者：Wang Xiaoguang Fang Xiang Yang Xueyan Ni Meng Wu Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2012
- 关键词：C?H activation Pd-catalyzed pyrazole HMG-CoA reductase inhibitor
- 质疑
- Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate被引量：6收藏
- 作者：Zhou, Jun Fang, Xiang Shao, Tongle Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2016
- 关键词：Palladium-catalyzed reaction Mono-alpha-arylation alpha-Aryl-alpha-fluoroketones
- 质疑
- One-Pot Addition-Intramolecular N-Cyclization of Carbamates Mediated by Alkali Metallic Reagents as an Approach to 4-(Fluoroalkyl)oxazolidin-2-ones被引量：5收藏
- 作者：Yang, Xue-Yan Fang, Xiang Ju, Zheng-Hua Hu, Yun-Li Wu, Fan-Hong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：SYNTHESIS-STUTTGART 2011
- 关键词：allyl carbamates 4-(fluoroalkyl)oxazolidin-2-ones addition-intramolecular N-cyclization alkali metallic reagents
- 质疑
- Regioselective nucleophilic addition of 3-aryl-5-difluoromethyl-isoxazoles to aldehydes被引量：5收藏
- 作者：Yang, Xueyan Fang, Xiang Zhang, Dong Yu, Yanlin Zhang, Zhengdong Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2013
- 关键词：Difluoromethylation Regioselectivity Nucleophilic addition reaction Isoxazole
- 质疑
- Palladium-catalyzed arylation of α,α-difluoro-allylic-β-hydroxyester被引量：4收藏
- 作者：Fang, Xiang Yang, Xueyan Yang, Xianjin Zhao, Min Chen, Guorong Wu, Fanhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON LETTERS 2006
- 关键词：alpha,alpha-difluoro-allylic-beta-hydroxyester Heck reaction aryl-substituted alpha,alpha-difluoro ketones
- 质疑
- One-pot synthesis of 4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)-δ-lactones by Reformatsky reaction被引量：4收藏
- 作者：Fang, Xiang Yang, Xueyan Zhao, Min Di, Qingfeng Wang, Xiaoguang Wu, Fanhong
- 机构：E China Univ Chem Technol;E China Univ Chem Technol;Nankai Univ
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2009
- 关键词：Reformatsky reaction Zinc Cuprous chloride gem-Difluoromethylenated delta-lactones
- 质疑
- 卡培他滨的合成被引量：4收藏
- 作者：党晓翠 赛达力木 赵敏 方向 杨雪艳
- 机构：华东理工大学化学与分子工程学院
- 来源：《中国新药杂志》 2013
- 关键词：D-核糖 卡培他滨 抗癌药 工艺改进
- 摘要：目的:合成抗肿瘤药物卡培他滨。方法:以D-核糖为原料,经缩酮化、酯化、还原、水解、乙酰化反应制得1,2,3-三-O-乙酰基-5-脱氧-6-呋喃核糖(7),7与硅醚化的5-氟胞嘧啶缩合制备了2',3'-O-二乙酰基-5'-...
- 下载全文在线阅读质疑
- 含氟内酯化合物的合成方法研究进展被引量：3收藏
- 作者：熊英 琚振华 王晓光 方向 吴范宏
- 机构：华东理工大学化学与分子工程学院结构可控先进功能材料及其制备重点实验室;中国科学院上海有机化学研究所有机氟化学重点实验室
- 来源：《有机化学》 2009
- 关键词：含氟内酯化合物 直接氟化法 含氟砌块法
- 摘要：内酯化合物广泛存在于天然产物和具有生理活性的物质中,因此,内酯化合物的合成一直是人们非常关心的一个研究领域,不仅作为天然产物的重要合成砌块,也用来合成一些精细化工产品和医药中间体.将氟原子或含氟基团引入到内酯化合物分子中...
- 下载全文在线阅读质疑
- Sodium dithionite initiated reaction of pent-4-en-1-amines with fluoroalkyl iodides for the synthesis of 2-fluoroalkyl pyrrolidine derivatives被引量：3收藏
- 作者：Zhu, Yaoping Yang, Xueyan Fang, Xiang Yang, Xianjin Ye, LingLing Cai, Wei Zhang, Yan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2011
- 关键词：Free radical addition-intramolecular nucleophilic substitution Fluoroalkyl iodide Pent-4-en-1-amine 2-Fluoroalkyl pyrrolidine
- 质疑
- β-烷氧乙烯基三氟甲基酮类化合物在有机合成中的应用被引量：2收藏
- 作者：陈阳 水声霞 方向 吴范宏
- 机构：华东理工大学化学与分子工程学院结构可控先进功能材料及其制备重点实验室;中国科学院上海有机化学研究所有机氟化学重点实验室
- 来源：《有机化学》 2008
- 关键词：含氟砌块 杂环化合物 β-烷氧乙烯基三氟甲基酮
- 摘要：β-烷氧乙烯基三氟甲基酮类化合物作为一类典型的含氟砌块,被广泛地应用于含氟有机化合物的合成中.综述了近年来此类含氟砌块的研究进展,特别是在合成各种含氟杂环化合物中的应用.
- 下载全文在线阅读质疑
- Synthesis of Fluoroalkylated Allylic-β-hydroxyesters and Fluoroalkylated β,Y-Epoxy Esters from Ethyl 3-Hydroxy-4-pentenoate被引量：2收藏
- 作者：Fang Xiang Xiong Ying Wang Qiong Zhao Min Wu Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2011
- 关键词：ethyl 3-hydroxy-4-pentenoate fluoroalkylated allylic-beta-hydroxyesters fluoroalkylated beta,gamma-epoxy esters
- 质疑
- 一种有效合成3-芳基-4-氟烷基-2-噁唑烷酮的方法被引量：1收藏
- 作者：杨波 赵敏 方向 杨雪艳 吴范宏
- 机构：华东理工大学化学与分子工程学院;上海应用技术学院化学与环境工程学院
- 来源：《有机化学》 2013
- 关键词：2-噁唑烷酮 氟烷基化 合成 N-环合
- 摘要：报道了一种方便有效地合成3-芳基-4-氟烷基-2-噁唑烷酮的方法.用芳基胺作为起始原料通过与氯甲酸烯丙基酯反应以95.8%～99.5%的收率得到芳基氨基甲酸烯丙基酯.芳基氨基甲酸烯丙基酯与氟烷基碘在乙腈和水的混合液中由连...
- 下载全文在线阅读质疑
- A Green and Novel Method for the Synthesis of 4,4-Difluoro-3-oxo-2-(triphenylphosphoranylidene) δ-Lactones by Reformatsky Reaction被引量：1收藏
- 作者：Ibrayim, Saidalimu Fang Xiang Zhang Dong Liu Wu Wu Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2011
- 关键词：aqueous medium 4-bromo-4,4-difluoro-3-oxo-2-(triphenylphosphoranylidene)butanoate Reformatsky reaction indium
- 质疑
