成果/Result
- Metabolic engineering of oleaginous yeast Yarrowia lipolytica for limonene overproduction被引量：134收藏
- 作者：Cao, Xuan Lv, Yu-Bei Chen, Jun Imanaka, Tadayuki Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY FOR BIOFUELS 2016
- 关键词：Limonene Yarrowia lipolytica Neryl diphosphate synthase 1 Limonene synthase
- Enhanced squalene biosynthesis in Yarrowia lipolytica based on metabolically engineered acetyl-CoA metabolism被引量：82收藏
- 作者：Huang, Yu-Ying Jian, Xing-Xing Lv, Yu-Bei Nian, Ke-Qing Gao, Qi Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2018
- 关键词：Yarrowia lipolytica Acetyl-CoA Squalene Metabolic network model Terpenoid
- Metabolic engineering of β-carotene biosynthesis in Yarrowia lipolytica被引量：72收藏
- 作者：Zhang, Xin-Kai Wang, Dan-Ni Chen, Jun Liu, Zhi-Jie Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2020
- 关键词：Yarrowia lipolytica beta-carotene CRISPR Cas9 system Metabolic engineering Fermenter cultivation
- Elevating Limonene Production in Oleaginous Yeast Yarrowia lipolytica via Genetic Engineering of Limonene Biosynthesis Pathway and Optimization of Medium Composition被引量：59收藏
- 作者：Cheng, Bo-Qian Wei, Liu-Jing Lv, Yu-Bei Chen, Jun Hua, Qiang
- 机构：East China Univ Sci & Technol;SCICBT
- 来源：BIOTECHNOLOGY AND BIOPROCESS ENGINEERING 2019
- 关键词：limonene Yarrowia lipolytica carbon source fed-batch fermentation
- Multicopy integrants of crt genes and co-expression of AMP deaminase improve lycopene production in Yarrowia lipolytica被引量：58收藏
- 作者：Zhang, Xin-Kai Nie, Ming-Yue Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2019
- 关键词：Lycopene Yarrowia lipolytica Multicopy integration AMP deaminase overexpression Fermenter cultivation
- Overproduction of Fatty Acid Ethyl Esters by the Oleaginous Yeast Yarrowia lipolytica through Metabolic Engineering and Process Optimization被引量：56收藏
- 作者：Gao, Qi Cao, Xuan Huang, Yu-Ying Yang, Jing-Lin Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：ACS SYNTHETIC BIOLOGY 2018
- 关键词：Yarrowia lipolytica fatty acid ethyl esters (FAEEs) promoter beta-oxidation ethanol
- Combining adaptive laboratory evolution and metabolic engineering for efficient erythritol production from crude glycerol by Yarrowia lipolytica被引量：55收藏
- 作者：Zhao, Ling-Xuan Li, Jiawei Wang, Ya-Ting Zhu, Qin-Yi Chen, Jun Liu, Zhi-Jie Liu, Feng Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; State Key Laboratory of Microbial Metabolism; Key Laboratory of Fermentation Engineering
- 来源：Journal of Biotechnology 2026
- 关键词：Biochemistry - Fermentation - Food additives - Glycerol - Metabolic engineering
- Analysis of metabolic fluxes for better understanding of mechanisms related to lipid accumulation in oleaginous yeast Trichosporon cutaneum被引量：53收藏
- 作者：Liu, Zhijie Gao, Yang Chen, Jun Imanaka, Tadayuki Bao, Jie Hua, Qiang
- 机构：E China Univ Sci & Technol;Ritsumeikan Univ
- 来源：BIORESOURCE TECHNOLOGY 2013
- 关键词：Metabolic flux analysis Trichosporon cutaneum Biodiesel Malic enzyme Citrate pyruvate cycle
- Anaerobic Degradation of Paraffins by Thermophilic Actinobacteria under Methanogenic Conditions被引量：45收藏
- 作者：Liu, Yi-Fan Chen, Jing Liu, Zhong-Lin Shou, Li-Bin Lin, Dan-Dan Zhou, Lei Yang, Shi-Zhong Liu, Jin-Feng Li, Wei Gu, Ji-Dong Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Pollut Control & Ecol Secur;East China Univ Sci & Technol
- 来源：ENVIRONMENTAL SCIENCE & TECHNOLOGY 2020
- 关键词：Petroleum reservoirs - Petroleum reservoir engineering - Addition reactions - Carbon dioxide - Methane
- Enhancement of VEGF-Mediated Angiogenesis by 2-N,6-O-Sulfated Chitosan-Coated Hierarchical PLGA Scaffolds被引量：41收藏
- 作者：Yu, Yuanman Chen, Jie Chen, Rui Cao, Lingyan Tang, Wei Lin, Dan Wang, Jing Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2015
- 关键词：Scaffold poly(lactic-co-glycolic acid) sulfated chitosan vascular endothelial growth factor angiogenesis
- Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources被引量：40收藏
- 作者：Zhao, Chen Gu, Deqing Nambou, Komi Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;SCICBT
- 来源：JOURNAL OF BIOTECHNOLOGY 2015
- 关键词：Yarrowia lipolytica Metabolomics Pathway abundance Carbon sources Lipid production
- Designing of a "cheap to run'' fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel被引量：39收藏
- 作者：Nambou, Komi Zhao, Chen Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCE TECHNOLOGY 2014
- 关键词：Biodiesel Fermentation Lipids Phosphate limitation Yarrowia lipolytica
- Analysis of metabolic fluxes for better understanding of mechanisms related to lipid accumulation in oleaginous yeast Trichosporon cutaneum被引量：35收藏
- 作者：Liu, Zhijie Gao, Yang Chen, Jun Imanaka, Tadayuki Bao, Jie Hua, Qiang
- 机构： State Key Laboratory of Bioreactor Engineering; Department of Biotechnology
- 来源：Bioresource Technology 2013
- 关键词：Yeast - Biodiesel - Metabolism - Sulfur compounds - Nitrogen compounds - Enzymes
- Enhancement of BMP-2-mediated angiogenesis and osteogenesis by 2-N,6-O-sulfated chitosan in bone regeneration被引量：32收藏
- 作者：Pan, Yuanzhong Chen, Jie Yu, Yuanman Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2018
- 关键词：Biosynthesis - Bone - Proteins - Sulfur compounds
- 一种大孔吸附树脂的合成及在红霉素提取中的应用被引量：31收藏
- 作者：陈骏 宁方红 张志丕 刘坐镇 邬行彦
- 机构：华东理工大学生物反应器工程国家重点实验室;上海市浦东新区环境保护监测站
- 来源：《中国抗生素杂志》 2002
- 关键词：二乙烯苯 大孔吸附树脂 红霉素 提取
- 摘要：以高含量工业级二乙烯苯悬浮聚合 ,合成了一系列大孔吸附树脂 ,从中筛选到一种树脂PT4 ,其对红霉素的吸附性能接近对红霉素吸附性能好的市售进口树脂AmberliteXAD 16。同时研究了用大孔吸附树脂提取红霉素的方法 ...
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- Tyrosinase inhibitory effect and inhibitory mechanism of tiliroside from raspberry被引量：29收藏
- 作者：Lu, Yan-hua Chen, Juan Wei, Dong-zhi Wang, Zheng-tao Tao, Xin-yi
- 机构：E China Univ Sci & Technol;Shanghai Univ TCM
- 来源：JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2009
- 关键词：Raspberry tiliroside Rubus chingii hu mushroom tyrosinase inhibition mechanism B16 mouse melanoma cells melanin
- Methanogenic Degradation of Long n-Alkanes Requires Fumarate-Dependent Activation被引量：28收藏
- 作者：Ji, Jia-Heng Liu, Yi-Fan Zhou, Lei Mbadinga, Serge Maurice Pan, Pan Chen, Jing Liu, Jin-Feng Yang, Shi-Zhong Sand, Wolfgang Gu, Ji-Dong Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Donghua Univ;Freiberg Univ Min & Technol;Univ Duisburg Essen
- 来源：APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2019
- 关键词：(1-methylalkyl)succinate biodegradation fumarate addition hydrocarbon long n-alkanes methanogenesis
- Multiple gene integration to promote erythritol production on glycerol in Yarrowia lipolytica被引量：27收藏
- 作者：Zhang, Ling Nie, Ming-Yue Liu, Feng Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOTECHNOLOGY LETTERS 2021
- 关键词：Erythritol Glycerol utilization Multiple gene integration Ribose 5-phosphate isomerase Yarrowia lipolytica
- Methanogenic biodegradation of C9 to C12n-alkanes initiated by Smithella via fumarate addition mechanism被引量：26收藏
- 作者：Ji, Jia-Heng Zhou, Lei Mbadinga, Serge Maurice Irfan, Muhammad Liu, Yi-Fan Pan, Pan Qi, Zhen-Zhen Chen, Jing Liu, Jin-Feng Yang, Shi-Zhong Gu, Ji-Dong Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Engn & Technol;Univ Hong Kong;East China Univ Sci & Technol
- 来源：AMB EXPRESS 2020
- 关键词：Alkanes Alkylsuccinates Fumarate addition Methanogenesis Oil reservoirs
- Enhancing Trans-Nerolidol Productivity in Yarrowia lipolytica by Improving Precursor Supply and Optimizing Nerolidol Synthase Activity被引量：23收藏
- 作者：Liu, Feng Liu, Shun-Cheng Qi, Yi-Ke Liu, Zhijie Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;North China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 2022
- 关键词：trans-nerolidol protein engineering peroxisomal acetyl-CoA pool pathway compartmentation Yarrowia lipolytica
- Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum被引量：22收藏
- 作者：Fan, Yuxiang Gao, Yang Zhou, Jie Wei, Liujing Chen, Jun Hua, Qiang
- 机构：E China Univ Sci & Technol;SCICBT
- 来源：JOURNAL OF BIOTECHNOLOGY 2014
- 关键词：Actinosynnema pretiosum Ansamitocin P-3 Fructose Medium optimization Transcription analysis
- Methanogenic degradation of branched alkanes in enrichment cultures of production water from a high-temperature petroleum reservoir被引量：21收藏
- 作者：Chen, Jing Liu, Yi-Fan Zhou, Lei Mbadinga, Serge Maurice Yang, Tao Zhou, Jing Liu, Jin-Feng Yang, Shi-Zhong Gu, Ji-Dong Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Hong Kong;East China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Alkylsuccinate iso-Alkanes or branched alkanes High-temperature petroleum reservoir Methanogenic degradation assA gene
- Recovery of dilute aqueous butanol by membrane vapor extraction with dodecane or mesitylene被引量：21收藏
- 作者：Chen, J. Razdan, N. Field, T. Liu, D. E. Wolski, P. Cao, X. Prausnitz, J. M. Radke, C. J.
- 机构：Univ Calif Berkeley;East China Univ Sci & Technol
- 来源：JOURNAL OF MEMBRANE SCIENCE 2017
- 关键词：Membrane vapor extraction Mass-transfer resistance Butanol or furfural recovery Recirculation flow cell Dodecane Mesitylene
- Metabolic profiling and flux distributions reveal a key role of acetyl-CoA in sophorolipid synthesis by Candida bombicola被引量：21收藏
- 作者：Yang, Linbing Li, Youyuan Zhang, Xinkai Liu, Ting Chen, Jun Wei, Liujing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2019
- 关键词：Sophorolipid Metabolic flux Metabolic profile Acetyl-CoA Candida bombicola Biosurfactant
- Genomic and Transcriptomic Evidence Supports Methane Metabolism in Archaeoglobi被引量：20收藏
- 作者：Liu, Yi-Fan Chen, Jing Zaramela, Livia S. Wang, Li-Ying Mbadinga, Serge Maurice Hou, Zhao-Wei Wu, Xiao-Lin Gu, Ji-Dong Zengler, Karsten Mu, Bo-Zhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Hong Kong;Univ Calif San Diego;East China Univ Sci & Technol
- 来源：MSYSTEMS 2020
- 关键词：horizontal gene transfer HGT metatranscriptomics methyl-coenzyme M reductase complex MCR complex oil reservoir methanogens
- Evaluation of metabolome sample preparation methods regarding leakage reduction for the oleaginous yeast Yarrowia lipolytica被引量：20收藏
- 作者：Zhao, Chen Nambou, Komi Wei, Liujing Chen, Jun Imanaka, Tadayuki Hua, Qiang
- 机构：E China Univ Sci & Technol
- 来源：BIOCHEMICAL ENGINEERING JOURNAL 2014
- 关键词：Yeast Metabolomics Separation Optimisation Amino acids DMSO quenching
- Reconstruction of genome-scale metabolic model of Yarrowia lipolytica and its application in overproduction of triacylglycerol被引量：19收藏
- 作者：Wei, Songsong Jian, Xingxing Chen, Jun Zhang, Cheng Hua, Qiang
- 机构：East China Univ Sci & Technol;KTH Royal Inst Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2017
- 关键词：Yarrowia lipolytica Genome-scale metabolic model iYL_2.0 Triacylglycerol Gene-level prediction targets
- Development of an economical fermentation platform for enhanced ansamitocin P-3 production in Actinosynnema pretiosum被引量：18收藏
- 作者：Liu, Ting Bessembayeya, Lyailya Chen, Jun Wei, Liu-Jing Hua, Qiang
- 机构：East China Univ Sci & Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2019
- 关键词：Ansamitocin P-3 Cane molasses Soybean powder Medium optimization
- Integrated pathway engineering and transcriptome analysis for improved astaxanthin biosynthesis in Yarrowia lipolytica被引量：18收藏
- 作者：Wang, Dan-Ni Feng, Jie Yu, Chen-Xi Zhang, Xin-Kai Chen, Jun Wei, Liu-Jing Liu, Zhijie Ouyang, Liming Zhang, Lixin Hua, Qiang Liu, Feng
- 机构：East China Univ Sci & Technol;Hubei Univ Technol;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2022
- 关键词：Astaxanthin Pathway engineering Transcriptome analysis Yarrowia lipolytica
- Metabolomic changes and metabolic responses to expression of heterologous biosynthetic genes for lycopene production in Yarrowia lipolytica被引量：17收藏
- 作者：Zhao, Chen Gao, Qi Chen, Jun Wei, Liujing Imanaka, Tadayuki Hua, Qiang
- 机构：East China Univ Sci & Technol;Northwest A&F Univ;Shanghai Collaborat Innovat Ctr Biomfg Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2017
- 关键词：Yarrowia lipolytica Metabolomics Pathway abundance Lipid Lycopene
