成果/Result
- Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs被引量：249收藏
- 作者：Chen, Xianjun Zhang, Dasheng Su, Ni Bao, Bingkun Xie, Xin Zuo, Fangting Yang, Lipeng Wang, Hui Jiang, Li Lin, Qiuning Fang, Mengyue Li, Ningfeng Hua, Xin Chen, Zhengda Bao, Chunyan Xu, Jinjin Du, Wenli Zhang, Lixin Zhao, Yuzheng Zhu, Linyong Loscalzo, Joseph Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOTECHNOLOGY 2019
- 关键词：Cells - Enzyme kinetics - Fluorescence - Mammals - Cytology
- MiR-139 inhibits invasion and metastasis of colorectal cancer by targeting the type I insulin-like growth factor receptor被引量：137收藏
- 作者：Shen, Ke Liang, Qiannan Xu, Ke Cui, Daling Jiang, Lin Yin, Peihao Lu, Yanhua Li, Qi Liu, Jianwen
- 机构：Putuo Hosp Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：BIOCHEMICAL PHARMACOLOGY 2012
- 关键词：miR-139 CRC Metastasis Invasion IGF-IR
- A versatile biosensing platform coupling CRISPR-Cas12a and aptamers for detection of diverse analytes被引量：88收藏
- 作者：Zhao, Xiangxiang Li, Shanshan Liu, Guang Wang, Zhong Yang, Zhiheng Zhang, Quanwei Liang, Mindong Liu, Jiakun Li, Zilong Tong, Yaojun Zhu, Guoliang Wang, Xinye Jiang, Lan Wang, Weishan Tan, Gao-Yi Zhang, Lixin
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Chinese Acad Agr Sci;Chinese Acad Sci;Shanghai Jiao Tong Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：CRISPR-Cas12a Aptamer Biosensing platform Diverse analyte Alpha fetoprotein detection Cocaine detection
- MiR-320a is Downregulated in Patients with Myasthenia Gravis and Modulates Inflammatory Cytokines Production by Targeting Mitogen-activated Protein Kinase 1被引量：69收藏
- 作者：Cheng, Zhuoan Qiu, Shaobo Jiang, Lin Zhang, Anle Bao, Wenjing Liu, Ping Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med;Liaoning Univ Tradit Chinese Med
- 来源：JOURNAL OF CLINICAL IMMUNOLOGY 2013
- 关键词：Myasthenia gravis miR-320a MAPK1 cytokine COX-2
- Ribosomal S6 protein kinase 4 promotes radioresistance in esophageal squamous cell carcinoma被引量：64收藏
- 作者：Li, Ming-Yang Fan, Lin-Ni Han, Dong-Hui Yu, Zhou Ma, Jing Liu, Yi-Xiong Li, Pei-Feng Zhao, Dan-Hui Chai, Jia Jiang, Lei Li, Shi-Liang Xiao, Juan-Juan Duan, Qiu-Hong Ye, Jing Shi, Mei Nie, Yong-Zhan Wu, Kai-Chun Liao, Dezhong Joshua Shi, Yu Wang, Yan Yan, Qing-Guo Guo, Shuang-Ping Bian, Xiu-Wu Zhu, Feng Zhang, Jian Wang, Zhe
- 机构：Fourth Mil Med Univ;Fourth Mil Med Univ;Fourth Mil Med Univ;East China Univ Sci & Technol;Guilin Med Univ
- 来源：JOURNAL OF CLINICAL INVESTIGATION 2020
- Large Stokes shift fluorescent RNAs for dual-emission fluorescence and bioluminescence imaging in live cells被引量：58收藏
- 作者：Jiang, Li Xie, Xin Su, Ni Zhang, Dasheng Chen, Xianjun Xu, Xiaochen Zhang, Bibi Huang, Kaiyi Yu, Jingwei Fang, Mengyue Bao, Bingkun Zuo, Fangting Yang, Lipeng Zhang, Rui Li, Huiwen Huang, Xinyi Chen, Zhengda Zeng, Qingmei Liu, Renmei Lin, Qiuning Zhao, Yuzheng Ren, Aiming Zhu, Linyong Yang, Yi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Fluorescence Diag Shanghai Biotech Co Ltd;Zhejiang Univ
- 来源：NATURE METHODS 2023
- Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p被引量：58收藏
- 作者：Tong, Yaojun Zhang, Jingyu Sun, Nuo Wang, Xiang-Ming Wei, Qi Zhang, Yu Huang, Ren Pu, Yingying Dai, Huanqin Ren, Biao Pei, Gang Song, Fuhang Zhu, Guoliang Wang, Xinye Xia, Xuekui Chen, Xiangyin Jiang, Lan Wang, Shenlin Ouyang, Liming Xie, Ning Zhang, Buchang Jiang, Yuanying Liu, Xueting Calderone, Richard Bai, Fan Zhang, Lixin Alterovitz, Gil
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Peking Univ;Georgetown Univ
- 来源：SCIENCE BULLETIN 2021
- 关键词：Candida albicans Berberine Multidrug-resistance Drug excretion transporter Mitochondria
- Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells被引量：56收藏
- 作者：Jiang, Lin Cheng, Zhuoan Qiu, Shaobo Que, Zujun Bao, Wenjing Jiang, Chao Zou, Fangyuan Liu, Ping Liu, Jianwen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;Liaoning Univ Tradit Chinese Med
- 来源：INTERNATIONAL IMMUNOPHARMACOLOGY 2012
- 关键词：Myasthenia gravis let-7 let-7c IL-10
- THE COMBINED EFFECTS OF HEMATOPORPHYRIN MONOMETHYL ETHER-SDT AND DOXORUBICIN ON THE PROLIFERATION OF QBC939 CELL LINES被引量：38收藏
- 作者：Liang, Lei Xie, Sheng Jiang, Lin Jin, Hui Li, Songgang Liu, Jianwen
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ULTRASOUND IN MEDICINE AND BIOLOGY 2013
- 关键词：HMME-SDT DOX Synergistic effect DNA damage Drug combination
- Genome-Based Discovery of Enantiomeric Pentacyclic Sesterterpenes Catalyzed by Fungal Bifunctional Terpene Synthases被引量：33收藏
- 作者：Jiang, Lan Zhang, Xue Sato, Yuya Zhu, Guoliang Minami, Atsushi Zhang, Weiyan Ozaki, Taro Zhu, Bin Wang, Zhixin Wang, Xinye Lv, Kangjie Zhang, Jingyu Wang, Yongheng Gao, Shushan Liu, Chengwei Hsiang, Tom Zhang, Lixin Oikawa, Hideaki Liu, Xueting
- 机构：East China Univ Sci Technol;Hokkaido Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Jinan Univ
- 来源：ORGANIC LETTERS 2021
- Deep Learning Based Drug Metabolites Prediction被引量：31收藏
- 作者：Wang, Disha Liu, Wenjun Shen, Zihao Jiang, Lei Wang, Jie Li, Shiliang Li, Honglin
- 机构：East China Univ Sci & Technol;Jiangzhong Pharmaceut Co Ltd
- 来源：FRONTIERS IN PHARMACOLOGY 2020
- 关键词：deep learning drug metabolism metabolites prediction reaction rules SMARTS
- A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137被引量：24收藏
- 作者：Zhang, Jingyu Li, Bixiao Qin, Yujie Karthik, Loganathan Zhu, Guoliang Hou, Chengjian Jiang, Lan Liu, Miaomiao Ye, Xin Liu, Mei Hsiang, Tom Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Anhui Univ;Chinese Acad Sci;Sri Shakthi Inst Engn & Technol Autonomous;Griffith Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Abyssomicin Proximicin Marine-derived Verrucosispora sp OSMAC Anti-influenza A virus
- Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134被引量：23收藏
- 作者：Han, Jianying Zhang, Jingyu Song, Zhijun Liu, Miaomiao Hu, Jiansen Hou, Chengjian Zhu, Guoliang Jiang, Lan Xia, Xuekui Quinn, Ronald J. Feng, Yunjiang Zhang, Lixin Hsiang, Tom Liu, Xueting
- 机构：Chinese Acad Sci;Griffith Univ;Univ Chinese Acad Sci;East China Univ Sci & Technol;Qilu Univ Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2019
- 关键词：Genome-based mining Halogenase Phytopathogenic fungus Bipolaris sorokiniana Antibacterial activity
- Design of a palette of SNAP-tag mimics of fluorescent proteins and their use as cell reporters被引量：23收藏
- 作者：Zhang, Dasheng Chen, Zhengda Du, Zengmin Bao, Bingkun Su, Ni Chen, Xianjun Ge, Yihui Lin, Qiuning Yang, Lipeng Hua, Yujie Wang, Shuo Hua, Xin Zuo, Fangting Li, Ningfeng Liu, Renmei Jiang, Li Bao, Chunyan Zhao, Yuzheng Loscalzo, Joseph Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Harvard Med Sch
- 来源：CELL DISCOVERY 2023
- Chaetoglobosins and azaphilones from Chaetomium globosum associated with Apostichopus japonicus被引量：21收藏
- 作者：Qi, Jun Jiang, Lan Zhao, Peipei Chen, Haiyan Jia, Xiaopeng Zhao, Liya Dai, Huanqin Hu, Jiansen Liu, Changheng Shim, Sang Hee Xia, Xuekui Zhang, Lixin
- 机构：Qilu Univ Technol;East China Univ Sci & Technol;Guangxi Univ;Duksung Womens Univ;Duksung Womens Univ
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2020
- 关键词：Apostichopus japonicus Chaetomium globosum Genome mining Chaetoglobosins Azaphilones Antimicrobial activity
- Recent advances in biotechnology for marine enzymes and molecules被引量：21收藏
- 作者：Zhang, Jingyu Jiang, Lan Chen, Xiangyin Lv, Kangjie Basiony, Mostafa Zhu, Guoliang Karthik, Loganathan Ouyang, Liming Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2021
- 关键词：Synthetic biology - Ecosystems - Metabolic engineering - Marine applications - Molecules
- Molecular networking assisted discovery and biosynthesis elucidation of the antimicrobial spiroketals epicospirocins被引量：18收藏
- 作者：Zhu, Guoliang Hou, Chengjian Yuan, Weize Wang, Zhenzhen Zhang, Jingyu Jiang, Lan Karthik, Loganathan Li, Bixiao Ren, Biao Lv, Kangjie Lu, Wanying Cong, Zhanren Dai, Huanqin Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Salem Microbes Private Ltd;Sichuan Univ;Sichuan Univ;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2020
- 关键词：Biochemistry - Chirality
- Antibacterial polyene-polyol macrolides and cyclic peptides from the marine-derived Streptomyces sp. MS110128被引量：18收藏
- 作者：Jiang, Lan Huang, Pei Ren, Biao Song, Zhijun Zhu, Guoliang He, Wenni Zhang, Jingyu Oyeleye, Ayokunmi Dai, Huanqin Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Zunyi Med Univ;Sichuan Univ;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Marine-derived Actinomycete Candida albicans Polyene Cyclic peptides
- The effects of PTBP3 silencing on the proliferation and differentiation of MKN45 human gastric cancer cells被引量：18收藏
- 作者：Chen, Bin Zhao, Ai-Guang Shao, Jin Mu, Xiao-Yan Jiang, Lin Liu, Jian-Wen
- 机构：Shanghai Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：LIFE SCIENCES 2014
- 关键词：PTBP3 Gastric cancer differentiation Proliferation
- Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi被引量：15收藏
- 作者：Jiang, Lan Zhu, Guoliang Han, Jianying Hou, Chengjian Zhang, Xue Wang, Zhixin Yuan, Weize Lv, Kangjie Cong, Zhanren Wang, Xinye Chen, Xiangyin Karthik, Loganathan Yang, Huanting Wang, Xuyuan Tan, Gaoyi Liu, Guang Zhao, Liya Xia, Xuekui Liu, Xiangyang Gao, Shushan Ma, Lei Liu, Mei Ren, Biao Dai, Huanqin Quinn, Ronald J. Hsiang, Tom Zhang, Jingyu Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Griffith Univ;Qilu Univ Technol;T3 Biosci LLC
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2021
- 关键词：Fungi Bifunctional terpene synthases Terpenoids Anti-inflammatory
- Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis被引量：13收藏
- 作者：Xie, Feng Dai, Shengwang Zhao, Yu Huang, Pei Yu, Shen Ren, Biao Wang, Qiushui Ji, Zengchun Alterovitz, Gil Zhang, Qi Zhang, Jingyu Chen, Xiangyin Jiang, Lan Song, Fuhang Liu, Hongwei Ausubel, Frederick M. Liu, Xueting Dai, Huanqin Zhang, Lixin
- 机构：Chinese Acad Sci;East China Univ Sci & Technol;Chinese Acad Sci;Massachusetts Gen Hosp;Sichuan Univ
- 来源：CELL CHEMICAL BIOLOGY 2020
- Heparin mimetics as potential intervention for COVID-19 and their bio-manufacturing被引量：13收藏
- 作者：Jiang, Lan Zhang, Tianji Lu, Hongzhong Li, Saijuan Lv, Kangjie Tuffour, Alex Zhang, Lixin Ding, Kan Li, Jin-Ping Li, Hongmei Liu, Xueting
- 机构：Nanjing Med Univ;East China Univ Sci & Technol;Natl Inst Metrol;Shanghai Jiao Tong Univ;Shanghai Inst Mat Med
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023
- 关键词：Heparin Biosynthesis Biological activities Bio-production
- Schultriene and nigtetraene: two sesterterpenes characterized from pathogenetic fungi via genome mining approach被引量：12收藏
- 作者：Jiang, Lan Yang, Huanting Zhang, Xue Li, Xiaoying Lv, Kangjie Zhang, Weiyan Zhu, Guoliang Liu, Chengwei Wang, Yongheng Hsiang, Tom Zhang, Lixin Liu, Xueting
- 机构：East China Univ Sci Technol;Northeast Forestry Univ;Jinan Univ;Univ Guelph
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2022
- 关键词：Bifunctional terpene synthases Sesterterpene Genome mining Heterologous expression Cyclization mechanisms
- Visible-light activatable coumarin-based phototriggers for fluorescence imaging with ultra-high photolysis efficiency被引量：12收藏
- 作者：Zhou, Renjie Yang, Lipeng Chen, Zhengda Jiang, Li Liu, Tuan Wang, Zhiqiang Huang, Xinyi Lin, Qiuning Gong, Xueqing Yang, Yi Zhu, Linyong
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2023
- 关键词：Efficiency - Fluorescence imaging - Scaffolds - Signal to noise ratio
- The transduction of His-TAT-p53 fusion protein into the human osteogenic sarcoma cell line (Saos-2) and its influence on cell cycle arrest and apoptosis被引量：11收藏
- 作者：Jiang, Lei Ma, Yushu Wang, Jinzhi Tao, Xinyi Wei, Dongzhi
- 机构：E China Univ Sci & Technol
- 来源：MOLECULAR BIOLOGY REPORTS 2008
- 关键词：apoptosis cell cycle G2 phase transduction
- A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain被引量：9收藏
- 作者：Shuai, Yuting Ju, Yi Li, Yuanhang Ma, Dini Jiang, Lan Zhang, Jingyu Tan, Gao-Yi Liu, Xueting Wang, Shenlin Zhang, Lixin Liu, Guang
- 机构：East China Univ Sci & Technol ECUST;East China Univ Sci & Technol ECUST;Shanghai Jiao Tong Univ
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2023
- 关键词：Phosphorothioate Sulfur binding domain Nucleic acid detection
- Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049被引量：9收藏
- 作者：Zhang, Jingyu Wang, Zhenzhen Song, Zhijun Karthik, Loganathan Hou, Chengjian Zhu, Guoliang Jiang, Lan Han, Jianying Ma, Rong Li, Li Zhang, Lixin Liu, Xueting Hsiang, Tom
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Med Sci & Peking Union Med Coll;Univ Guelph;Univ Chinese Acad Sci
- 来源：SYNTHETIC AND SYSTEMS BIOTECHNOLOGY 2019
- 关键词：Wheat pathogenic fungus Anticancer Antibacterial Natural product
- Typification of Sphaeria sinensis to precisely fix the application of the name of the economically important Chinese caterpillar fungus, Ophiocordyceps sinensis被引量：8收藏
- 作者：Li, Yi Jiang, Lan Hawksworth, David L. Wang, Yong-Hui Lu, Jiao-Jiao Yao, Yi-Jian
- 机构：Yangzhou Univ;Chinese Acad Sci;East China Univ Sci & Technol;Royal Bot Gardens;Nat Hist Museum
- 来源：TAXON 2021
- 关键词：entomogenous fungi ghost moth medicinal fungi Hirsutella ITS metagenome Thitarodes
- Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases被引量：8收藏
- 作者：Wang, Xinye Wang, Zhixin Zhu, Guoliang Jiang, Lan Zhang, Weiyan Huang, Yiyi Cong, Zhanren Zhao, Yi-Lei Xu, Jian-He Hsiang, Tom Zhang, Lixin Chen, Qi Liu, Xueting
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Jiao Tong Univ;Univ Guelph
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Catalysis - Terpenes
- Clinical Study of Effects of Jian Ji Ning, a Chinese Herbal Medicine Compound Preparation, in Treating Patients with Myasthenia Gravis via the Regulation of Differential MicroRNAs Expression in Serum被引量：7收藏
- 作者：Jiang, Chao Liu, Ping Zhang, Jingsheng Bao, Wenjing Qiu, Shaobo Liang, Yan Jiang, Lin
- 机构：Shanghai Univ Tradit Chinese Med;Liaoning Univ Tradit Chinese Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 2014
