成果/Result
- Recent developments in multimodality fluorescence imaging probes被引量：188收藏
- 作者：Zhao, Jianhong Chen, Junwei Ma, Shengnan Liu, Qianqian Huang, Lixian Chen, Xiani Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ACTA PHARMACEUTICA SINICA B 2018
- 关键词：Optical imaging Fluorescence Multimodality Near-infrared fluorescence Nanoprobe Computedtomography Magneticresonance imaging Positronemissiontomo graphy Single-photonemission computedtomography Photoacoustic imaging
- Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release被引量：135收藏
- 作者：Yuan, Zeting Ye, Yajing Gao, Feng Yuan, Huihui Lan, Minbo Lou, Kaiyan Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2013
- 关键词：Chitosan Cyclodextrin Ionic gelation Nano-drug delivery system
- Near-infrared fluorescent probes for imaging of amyloid plaques in Alzheimer's disease被引量：123收藏
- 作者：Tong, Hongjuan Lou, Kaiyan Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：ACTA PHARMACEUTICA SINICA B 2015
- 关键词：Alzheiimer's disease Blood-brain barrier Fluoresence probe Near-infrared fluorescence Optical imaging Amyloid-beta plagues
- New small-molecule drug design strategies for fighting resistant influenza A被引量：78收藏
- 作者：Shen, Zuyuan Lou, Kaiyan Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：ACTA PHARMACEUTICA SINICA B 2015
- 关键词：Influenza A virus Drug discovery Resistance M2 ion channel Neuramindase
- Enzymatic Cleavage and Subsequent Facile Intramolecular Transcyclization for in Situ Fluorescence Detection of γ-Glutamyltranspetidase Activities被引量：78收藏
- 作者：Tong, Hongjuan Zheng, Yongjun Zhou, Li Li, Xiangmin Qian, Rui Wang, Rui Zhao, Jianhong Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：ANALYTICAL CHEMISTRY 2016
- 关键词：Cancer cells - Cells - Diseases - Diagnosis - Cytology - Fluorescence spectroscopy - Probes - Enzymes - Product design
- Analyte Regeneration Fluorescent Probes for Formaldehyde Enabled by Regiospecific Formaldehyde-Induced Intramolecularity被引量：72收藏
- 作者：Xu, Hang Xu, Huan Ma, Shengnan Chen, Xiani Huang, Lixian Chen, Junwei Gao, Feng Wang, Rui Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2018
- 关键词：Fluorescence spectroscopy - Fluorescence - Probes - Molecules
- A novel lactoferrin-modified β-cyclodextrin nanocarrier for brain-targeting drug delivery被引量：57收藏
- 作者：Ye, Yajing Sun, Yi Zhao, Hongli Lan, Minbo Gao, Feng Song, Chao Lou, Kaiyan Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：INTERNATIONAL JOURNAL OF PHARMACEUTICS 2013
- 关键词：beta-cyclodextrin derivatives Lactoferrin Transferrin Brain-targeting Nano-drug delivery system
- The preparation, characterization, and pharmacokinetic studies of chitosan nanoparticles loaded with paclitaxel/dimethyl-β-cyclodextrin inclusion complexes被引量：57收藏
- 作者：Ye, Ya-Jing Wang, Yun Lou, Kai-Yan Chen, Yan-Zuo Chen, Rongjun Gao, Feng
- 机构：E China Univ Sci & Technol;Univ London Imperial Coll Sci Technol & Med;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：INTERNATIONAL JOURNAL OF NANOMEDICINE 2015
- 关键词：dimethyl-beta-cyclodextrin inclusion complex chitosan nanoparticles drug delivery sustained release paclitaxel
- Divergent Synthesis of Imidazoles and Quinazolines via Pd(OAc)2-Catalyzed Annulation of N-Allylamidines被引量：53收藏
- 作者：Xu, Li Li, Hongxian Liao, Ziyang Lou, Kaiyan Xie, Hexin Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：ORGANIC LETTERS 2015
- Fluorescent theranostic agents for Hg2+ detection and detoxification treatment被引量：47收藏
- 作者：Song, Chao Yang, Wen Zhou, Nannan Qian, Rui Zhang, Yajun Lou, Kaiyan Wang, Rui Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMICAL COMMUNICATIONS 2015
- Orchestration of dual cyclization processes and dual quenching mechanisms for enhanced selectivity and drastic fluorescence turn-on detection of cysteine被引量：46收藏
- 作者：Tong, Hongjuan Zhao, Jianhong Li, Xiangmin Zhang, Yajun Ma, Shengnan Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMICAL COMMUNICATIONS 2017
- Preparation and characterization of mPEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity被引量：44收藏
- 作者：Fu, Dong-Jun Jin, Yu Xie, Mu-Qing Ye, Ya-Jing Qin, Dong-Dong Lou, Kai-Yan Chen, Yan-Zuo Gao, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2014
- 关键词：Self-assembled micelles Methoxy polyethylene glycol grafted chitosan 5-Fluorouracil Controlled-release
- Cyclodextrin/chitosan nanoparticles for oral ovalbumin delivery: Preparation, characterization and intestinal mucosal immunity in mice被引量：43收藏
- 作者：He, Muye Zhong, Chen Hu, Huibing Jin, Yu Chen, Yanzuo Lou, Kaiyan Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES 2019
- 关键词：beta-cyclodextrin Chitosan nanoparticles Ovalbumin Oral protein delivery Intestinal mucosal immunity
- Exploration of Glyoxals' Level Changes in Endoplasmic Reticulum During Ferroptosis by a Photocaged Fluorescent Probe被引量：41收藏
- 作者：Xing, Wanjin Zhang, Yirong Ma, Huijuan Shen, Shuran Wang, Sinan Xu, Huan Wang, Wei Lou, Kaiyan
- 机构： State Key Laboratory of Bioreactor Engineering; School of Biomedical Engineering; School of Public Health; Department of Pharmacology and Toxicology
- 来源：SSRN 2024
- 关键词：Cell death - Fluorescence - Fluorescence spectroscopy - Quenching
- Rational Design of an Ultrasensitive and Highly Selective Chemodosimeter by a Dual Quenching Mechanism for Cysteine Based on a Facile Michael-Transcyclization Cascade Reaction被引量：37收藏
- 作者：Li, Xiangmin Zheng, Yongjun Tong, Hongjuan Qian, Rui Zhou, Lin Liu, Guixia Tang, Yun Li, Hao Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2016
- 关键词：cascade reactions chemodosimeter click chemistry cysteine fluorescent probes
- A PET-based fluorescent probe for monitoring labile Fe(II) pools in macrophage activations and ferroptosis被引量：30收藏
- 作者：Xing, Wanjin Xu, Hang Ma, Huijuan Abedi, Syed Ali Abbas Wang, Shanshan Zhang, Xingchen Liu, Xiaogang Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Singapore Univ Technol & Design;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2022
- 关键词：Fluorophores - Macrophages - Fluorescence spectroscopy - Iron compounds - Chemical activation - Fluorescence quenching
- A pinacol boronate caged NIAD-4 derivative as a near-infrared fluorescent probe for fast and selective detection of hypochlorous acid被引量：30收藏
- 作者：Tong, Hongjuan Zhang, Yajun Ma, Shengnan Zhang, Minghao Wang, Na Wang, Rui Lou, Kaiyan Wang, Wei
- 机构：Sch Pharm;East China Univ Sci & Technol;Univ New Mexico
- 来源：CHINESE CHEMICAL LETTERS 2018
- 关键词：Fluorescent probe Hypochlorous acid Boronate Reactive oxygen species (ROS) Near-infrared (NIR) imaging
- Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier被引量：29收藏
- 作者：Chen, Yan-Zuo Huang, Yu-Kun Chen, Yuan Ye, Ya-Jing Lou, Kai-Yan Gao, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Hlth Sci
- 来源：CHINESE CHEMICAL LETTERS 2015
- 关键词：Chitosan Cyclodextrin derivatives Ionic gelation method Drug delivery system
- Formaldehyde reinforces pro-inflammatory responses of macrophages through induction of glycolysis被引量：28收藏
- 作者：Ma, Huijuan Lin, Jinxuan Li, Linyi Ding, Zhaoqian Huang, Ping Song, Xiaodong Lou, Kaiyan Wang, Wei Xu, Huan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：CHEMOSPHERE 2021
- 关键词：Formaldehyde Macrophage Glycolysis Pro-inflammatory responses Lipopolysaccharide stimulation HIF-1 alpha
- Spatiotemporally controllable diphtheria toxin expression using a light-switchable transgene system combining multifunctional nanoparticle delivery system for targeted melanoma therapy被引量：28收藏
- 作者：He, Muye Wang, Yan Chen, Xianjun Zhao, Yuzheng Lou, Kaiyan Wang, Yujie Huang, Lei Hou, Xinyu Xu, Jiajun Cai, Xiaoran Cheng, Yi Lan, Minbo Yang, Yi Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF CONTROLLED RELEASE 2020
- 关键词：Light-switchable gene expression Diphtheria toxin Melanoma Nanoparticle delivery system
- Fluorophore-Promoted Facile Deprotonation and Exocyclic Five-Membered Ring Cyclization for Selective and Dynamic Tracking of Labile Glyoxals被引量：27收藏
- 作者：Xu, Huan Liu, Qianqian Song, Xiaodong Wang, Chao Wang, Xinru Ma, Shengnan Wang, Xiaolei Feng, Yan Meng, Xiangming Liu, Xiaogang Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Singapore Univ Technol & Design;Anhui Univ
- 来源：ANALYTICAL CHEMISTRY 2020
- 关键词：Fluorophores - Formaldehyde - Metabolism - Mass spectrometry - Mammals - Liquid chromatography - Metabolites - Amino acids - Nitric oxide - Complex networks - Modulation - Diagnosis
- RETRACTED: The therapeutic effect of methotrexate-conjugated Pluronic-based polymeric micelles on the folate receptor-rich tumors treatment (Retracted Article)被引量：24收藏
- 作者：Chen, Yanzuo Zhang, Wei Huang, YuKun Gao, Feng Sha, Xianyi Lou, Kaiyan Fang, Xiaoling
- 机构：E China Univ Sci & Technol;Fudan Univ;Fudan Univ;Fudan Univ;Eastern Virginia Med Sch
- 来源：INTERNATIONAL JOURNAL OF NANOMEDICINE 2015
- 关键词：methotrexate-conjugated mixed micelles folate receptor Pluronic KBv cells
- β-Cyclodextrin-Based Inclusion Complexation Bridged Biodegradable Self-Assembly Macromolecular Micelle for the Delivery of Paclitaxel被引量：23收藏
- 作者：Chen, Yanzuo Huang, Yukun Qin, Dongdong Liu, Wenchao Song, Chao Lou, Kaiyan Wang, Wei Gao, Feng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：PLOS ONE 2016
- A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout被引量：21收藏
- 作者：Xu, Hang Ma, Shengnan Liu, Qianqian Huang, Lixian Wu, Peimin Liu, Xiaolin Huang, Yali Wang, Xiaolei Xu, Huan Lou, Kaiyan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2019
- Accumulation of Intracellular Ferrous Iron in Inflammatory-Activated Macrophages被引量：20收藏
- 作者：Ma, Huijuan Shu, Qi Li, Dan Wang, Tingqian Li, Linyi Song, Xiaodong Lou, Kaiyan Xu, Huan
- 机构：East China Univ Sci & Technol;Fudan Univ
- 来源：BIOLOGICAL TRACE ELEMENT RESEARCH 2022
- 关键词：Ferrous iron Macrophages Inflammatory activation Polarization Ulcerative colitis Iron metabolism
- Nanoparticle structure transformation of mPEG grafted chitosan with rigid backbone induced by α-cyclodextrin被引量：18收藏
- 作者：Huang, Lei Chen, Jiaojiao He, Muye Hou, Xinyu Lu, Yiben Lou, Kaiyan Gao, Feng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHINESE CHEMICAL LETTERS 2019
- 关键词：alpha-Cyclodextrin mPEG Grafted chitosan Self-assembly Nanoparticle Drug delivery
- An "AND"-logic-gate-based fluorescent probe with dual reactive sites for monitoring extracellular methylglyoxal level changes of activated macrophages被引量：16收藏
- 作者：Wang, Wenli Chen, Junwei Ma, Huijuan Xing, Wanjin Lv, Nan Zhang, Baoning Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Univ Arizona;Univ Arizona
- 来源：CHEMICAL COMMUNICATIONS 2021
- 关键词：Fluorescence - Probes - Computer circuits - Macrophages
- A compact fluorescence/circular dichroism dual-modality probe for detection, differentiation, and detoxification of multiple heavy metal ions via bond-cleavage cascade reactions被引量：15收藏
- 作者：Chen, Junwei Wang, Na Tong, Hongjuan Song, Chao Ma, Huijuan Zhang, Yajun Gao, Feng Xu, Huan Wang, Wei Lou, Kaiyan
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shaanxi Inst Int Trade & Commerce;Univ Arizona;Univ Arizona
- 来源：CHINESE CHEMICAL LETTERS 2021
- 关键词：Fluorescent probe Circular dichroism Heavy metal ions Dual-modality Detoxification Cascade reaction Divergent responses
- Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells被引量：15收藏
- 作者：Wang, Xiaolei Lou, Kaiyan Song, Xiaodong Ma, Huijuan Zhou, Xinyi Xu, Huan Wang, Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Univ Arizona;Univ Arizona
- 来源：TOXICOLOGY AND APPLIED PHARMACOLOGY 2020
- 关键词：Mebendazole T cell acute lymphoblastic leukemia Notch1 Drug repurposing Apoptosis Chemoresistance
- 提高学生学习药用高分子材料学课程积极性的探索被引量：15收藏
- 作者：高峰 陈彦佐 楼开炎
- 机构：华东理工大学药学院
- 来源：《药学教育》 2016
- 关键词：药用高分子材料学 教学方法 教学技巧
- 摘要：药用高分子材料学是药物制剂专业的主干课程之一。为提高学生学习药用高分子材料学课程的积极性,提高教学效率,达到多角度提升学生素质的目标,从教学技巧的运用和改进教学方法两个方面进行教学改革探讨。
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