成果/Result
- Rhodium(III)- and Iridium(III)-Catalyzed C7 Alkylation of Indolines with Diazo Compounds被引量：151收藏
- 作者：Ai, Wen Yang, Xueyan Wu, Yunxiang Wang, Xuan Li, Yuanchao Yang, Yaxi Zhou, Bing
- 机构：Chinese Acad Sci;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2014
- 关键词：alkylation C-H activation indolines iridium rhodium
- Highly Enantioselective Construction of 3-Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl -Fluorinated gem-Diols to N-Benzyl Isatins被引量：96收藏
- 作者：Saidalimu, Ibrayim Fang, Xiang He, Xiao-Peng Liang, Jing Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2013
- 关键词：aldol reaction carboncarbon bond cleavage organocatalysis reaction mechanisms trifluoroacetate release
- AIBN-initiated radical addition of gem-difluorinated alkyl iodides to alkynes and the Pd-catalyzed Sonogashira coupling reaction of E-phenyl difluoromethylene vinylic iodides with terminal alkynes被引量：54收藏
- 作者：Fang, Xiang Yang, Xueyan Yang, Xianjin Mao, Shenjie Wang, Zhonghua Chen, Guorong Wu, Fanhong
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2007
- 关键词：alkynes radical addition difluoromethylene vinylic iodides sonogashira coupling
- Rh(III)- or Ir(III)-catalyzed ynone synthesis from aldehydes via chelation-assisted C-H bond activation被引量：41收藏
- 作者：Ai, Wen Wu, Yunxiang Tang, Huanyu Yang, Xueyan Yang, Yaxi Li, Yuanchao Zhou, Bing
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMICAL COMMUNICATIONS 2015
- One-pot synthesis of α-fluoro-β-amino acid and indole spiro-derivatives via C-N bond cleavage/formation被引量：40收藏
- 作者：Tang, Chen-Yu Wang, Ge Yang, Xue-Yan Wu, Xin-Yan Sha, Feng
- 机构：E China Univ Sci & Technol; E China Univ Sci & Technol
- 来源：TETRAHEDRON LETTERS 2014
- 关键词：Arynes Aziridines Fluorination beta-Amino acids Indole spiro-derivatives
- Organocatalytic Asymmetric Michael Addition/Carbon-Carbon Bond Cleavage of Trifluoromethyl α-Fluorinated gem-Diols to Nitroolefins被引量：39收藏
- 作者：Saidalimu, Ibrayim Fang, Xiang Lv, Wenwen Yang, Xueyan He, Xiaopeng Zhang, Jingyuan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2013
- 关键词：asymmetric Michael addition carbon-carbon bond cleavage thiourea catalysts trifluoroacetate release trifluoromethyl -fluorinated gem-diols
- Comparative studies on the enantioselective fluorination of oxindoles with structurally modified N-fluorobenzenesulfonimides被引量：33收藏
- 作者：Zhang, Yan Yang, Xian-Jin Xie, Tian Chen, Guan-Long Zhu, Wen-Hua Zhang, Xiao-Qi Yang, Xue-Yan Wu, Xin-Yan He, Xiao-Peng He, Hao-Ming
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;Wengfu Grp Co Ltd
- 来源：TETRAHEDRON 2013
- 关键词：N-Fluorobenzenesulfonimides Enantioselectivity Fluorination Oxindole
- Gold(I) or Gold(III) as Real Intermediate Species in Gold-Catalyzed Cycloaddition Reactions of Enynal/Enynone?被引量：30收藏
- 作者：Zhang, Caiyun Wang, Gendi Zhan, Licheng Yang, Xueyan Wang, Jiwei Wei, Yin Xu, Sheng Shi, Min Zhang, Jun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACS CATALYSIS 2020
- 关键词：gold(I) catalysis gold(III) catalysis cycloaddition enynal/enynone reaction intermediates
- Regio- and diastereoselective construction of 1′,2′-(dihydrospiro[indoline-3,3′-pyrrol]-2′-yl)acrylates through phosphine-catalyzed [4+1] annulation of Morita-Baylis-Hillman carbonates with oxindole-derived α, β-unsaturated imines被引量：25收藏
- 作者：Lei, Yu Zhang, Xiao-Nan Yang, Xue-Yan Xu, Qin Shi, Min
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：RSC ADVANCES 2015
- 关键词：Phosphorus compounds - Amides - Stereoselectivity - Rate constants - Catalysis - Salts
- New preparation of difluoroiodomethylsulfanylbenzenes and their radical addition to unsaturated compounds initiated by sodium dithionite被引量：19收藏
- 作者：Yang, Xueyan Fang, Xiang Yang, Xianjin Zhao, Min Han, Yizheng Shen, Yongjia Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：TETRAHEDRON 2008
- 关键词：difluoroiodomethylsulfanylbenzene difluoromethylene gamma-butyrolactone addition tetrahydrofuran derivatives
- Synthesis of difluoromethylene-containing 1,2,4-oxadiazole compounds via the reaction of 5-(Difluoroiodomethyl)-3-phenyl-1,2,4-oxadiazole with unsaturated compounds initiated by sodium dithionite被引量：18收藏
- 作者：Yang, Xueyan Wang, Zhonghua Fang, Xiang Yang, Xianjin Wu, Fanhong Shen, Yongjia
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：SYNTHESIS-STUTTGART 2007
- 关键词：difluoromethylene 1,2,4-oxadiazole gamma-butyrolactone addition cyclization
- The Regio-specific solvent controlled asymmetric Strecker reaction of trifluoromethyl α,β-unsaturated N-tert-butanesulfinyl ketimines with trimethylsilyl cyanide被引量：17收藏
- 作者：Yuan, Xiao-Ming Xu, Jian Liu, Zhen-Jiang Yang, Xian-Jin Wang, Li-Min Zhang, Yan Yang, Xue-Yan He, Xiao-Peng Liu, Jin-Tao
- 机构：Shanghai Inst Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2012
- 关键词：Solvent controlled Asymmetric Strecker reaction (Rs)-trifluoromethyl alpha,beta-Unsaturated N-tert-butanesulfinyl ketimine Trimethylsilyl cyanide
- The investigation of fluorination reaction of p-substituted benzenesulfonimides with fluorine-nitrogen mixed gas to synthesize NFSI analogues被引量：15收藏
- 作者：Chen, Guanlong Chen, Fuli Zhang, Yan Yang, Xueyan Yuan, Xiaoming Wu, Fanhong Yang, Xianjin
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;Wengfu Grp Co Ltd
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2012
- 关键词：Benzenesulfonimide Fluorination NFSI analogue
- Axially Chiral Copper Catalyst for Asymmetric Synthesis of Valuable Diversely Substituted BINOLs被引量：14收藏
- 作者：Gao, Jun Wang, Pengyang Shen, Ahui Yang, Xueyan Cen, Shouyi Zhang, Zhipeng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2024
- 关键词：enantioselective copper BINOL oxidativecoupling axial chirality 2-naphthols
- Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives被引量：13收藏
- 作者：Yang, Xueyan Wang, Zhonghua Zhu, Yaoping Fang, Xiang Yang, Xianjin Wu, Fanhong Shen, Yongjia
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2007
- 关键词：addition cyclization fluorine-containing tetrahydrofuran
- Synthesis of fluoroalkyl-δ-lactones from polyfluoroalkyl iodides and 5-hexenoic acids被引量：11收藏
- 作者：Fang, Xiang Ying, Qi Chen, Yang Yang, Xueyan Yang, Xianjin Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2008
- 关键词：5-hexenoic acids polyfluoroalkyl iodide delta-valerolactone sodium dithionite polyfluoroalkyl-lactonization
- A new and direct route to 3-fluoromethyl substituted pyrazol-4-acrylates via Pd-catalyzed C-H activation被引量：10收藏
- 作者：Wang, Xiaoguang Fang, Xiang Xiao, Hongyuan Gong, Dongming Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON 2013
- 关键词：3-Fluoromethyl pyrazoles Pd-catalyzed C4-H activation Benzoquinone Concerted metalation-deprotonation (CMD)
- Experimental and theoretical studies on rhodium-catalyzed direct C-H benzoxylation reaction被引量：10收藏
- 作者：Jin, Chen Wang, Guimin Yang, Xueyan Zhu, Weiliang Yang, Yaxi
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：TETRAHEDRON LETTERS 2018
- 关键词：Rh(III)-catalyzed C-H benzoxylation DFT calculations
- Facile synthesis of 2-fluoroindenones via a Knoevenagel condensation/palladium-catalyzed annulation被引量：9收藏
- 作者：Su, Yue Fang, Xiang Zhou, Jun Bian, Yizhen Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2018
- 关键词：2-Fluoroindenones Domino reaction Knoevenagel condensation Intramolecular heck cyclization
- Microwave-assisted expeditious synthesis of 5-fluoroalkyl-3-(aryl/alkyl)-oxazolidin-2-ones被引量：9收藏
- 作者：Yang, Bo Shi, Luyan Wu, JingJing Fang, Xiang Yang, Xueyan Wu, Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON 2013
- 关键词：2-Oxazolidin-2-ones Free radical addition One-pot reaction Microwave irradiation Fluoroalkyl iodide
- Synthesis of bromodifluoromethyl substituted pyrazoles and isoxazoles被引量：8收藏
- 作者：Yang, Xueyan Shui, Shengxia Chen, Xi He, Hai'ou Wu, Fanhong
- 机构：Shanghai Inst Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Nankai Univ
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2010
- 关键词：Bromodifluoromethyl Pyrazoles Isoxazoles Regioselectivity Synthesis
- Highly stereoselective monofluoroolefination: Facile access to (E)-α-fluorinated arylvinyl sulfones from trifluoromethyl α-fluorinated arylsulfonyl gem-diols被引量：7收藏
- 作者：Fang, Xiang Zhou, Jun Wang, Wang Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：TETRAHEDRON LETTERS 2020
- 关键词：Monofluoroolefination Stereoselective Trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols alpha-Fluorinated arylvinyl sulfones
- I2/TBHP-Promoted Approach to α-Keto Esters from Trifluoromethyl β-Diketones and Alcohols via C-C Bond Cleavage被引量：7收藏
- 作者：Shao, Tongle Fang, Xiang Zhou, Jun Jin, Chen Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：SYNLETT 2017
- 关键词：trifluoromethyl beta-diketones alpha-keto esters C-C bond cleavage C-O coupling alcohols
- Studies on the superhydrophobic properties of polypropylene/polydimethylsiloxane/graphite fluoride composites被引量：6收藏
- 作者：He, Hao-Ming Gao, Lei Yang, Xian-Jin Guo, Wei-Hong Li, Hui Xie, Tian Yang, San-Ke Wang, Jiang-Ping Zhang, Yan Yang, Xue-Yan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci;Wengfu Grp Co Ltd
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2013
- 关键词：Polypropylene Polydimethylsiloxane Graphite fluoride Composite Sandpapering Superhydrophobicity
- Construction of N-Boc monofluoromethyl aryl sulfones via Mannich reaction of α-amido sulfones with trifluoromethyl α-fluorinated arylsulfonyl gem-diols被引量：6收藏
- 作者：Wang, Wang Fang, Xiang Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2020
- 关键词：Mannich reaction Nucleophilic monofluoromethylation Trifluoromethyl alpha-fluorinated arylsulfonyl gem-diols Detrifluoroacetylation
- One-Pot Synthesis of α-Fluoroketones and 3-Fluoro-2,4-diarylfurans from Trifluoromethyl β-Diketones via Decarboxylation被引量：6收藏
- 作者：Shao, Tongle Fang, Xiang Yang, Xueyan
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ Toronto
- 来源：SYNLETT 2015
- 关键词：fluorine alpha-fluoroketones 3-fluorofurans one-pot decarboxylation
- Synthesis of 1,3,5-Trisubstituted [4-tert-Butyl 2-(5,5-difluoro-2,2-dimethyl-6-vinyl-1,3-dioxan-4-yl)acetate]pyrazoles via a Pd-Catalyzed C-H Activation被引量：6收藏
- 作者：Wang Xiaoguang Fang Xiang Yang Xueyan Ni Meng Wu Fanhong
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Shanghai Inst Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2012
- 关键词：C?H activation Pd-catalyzed pyrazole HMG-CoA reductase inhibitor
- 抗组胺药非索非那定盐酸盐的合成被引量：6收藏
- 作者：吕彬华 杨雪艳 吴范宏
- 机构：华东理工大学化学与制药学院
- 来源：《中国药物化学杂志》 2004
- 关键词：药物化学 工艺改进 化学合成 非索非那定盐酸盐 2-甲基-2-苯基丙酸
- 摘要：目的研究抗组胺药非索非那定盐酸盐 (fexofenadinehydrochloride)的合成。 方法以 2 甲基 2 苯基丙酸为起始原料 ,通过氯化、胺化、傅 克酰基化、缩合、还原、水解及成盐 7步反应 ,合成得...
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- Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate被引量：6收藏
- 作者：Zhou, Jun Fang, Xiang Shao, Tongle Yang, Xueyan Wu, Fanhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Inst Technol
- 来源：JOURNAL OF FLUORINE CHEMISTRY 2016
- 关键词：Palladium-catalyzed reaction Mono-alpha-arylation alpha-Aryl-alpha-fluoroketones
- 盐酸度洛西汀的合成工艺改进研究被引量：5收藏
- 作者：朱占群 杨雪艳 张俊 杨先金 吴范宏
- 机构：华东理工大学化学与分子工程学院
- 来源：《中国新药杂志》 2009
- 关键词：盐酸度洛西汀 抗抑郁药 合成
- 摘要：目的:对盐酸度洛西汀的合成工艺进行改进。方法:以2-乙酰噻吩为原料,经Mannich反应、还原、醚化、化学拆分、脱甲基、水解、氯化铵成盐等七步反应合成了目标产物,考察了每步反应的影响因素。结果:所得盐酸度洛西汀(1),H...
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