成果/Result
- Stable, Bright, and Long-Fluorescence-Lifetime Dyes for Deep-Near-Infrared Bioimaging被引量：121收藏
- 作者：Li, Jin Dong, Yan Wei, Ruwei Jiang, Guanyu Yao, Cheng Lv, Meng Wu, Yuyang Gardner, Sarah H. Zhang, Feng Lucero, Melissa Y. Huang, Jian Chen, Hao Ge, Guangbo Chan, Jefferson Chen, Jinquan Sun, Haitao Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Normal Univ;Chinese Acad Sci;Univ Illinois
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Biocompatibility - Chlorine compounds - Fluorophores - Infrared devices - Medical applications - Photobleaching - Scaffolds - Scaffolds (biology)
- Two-Dimensional Design Strategy to Construct Smart Fluorescent Probes for the Precise Tracking of Senescence被引量：109收藏
- 作者：Gao, Ying Hu, Yulu Liu, Qimeng Li, Xiaokang Li, Xinming Kim, Chu-Young James, Tony D. Li, Jian Chen, Xi Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Texas El Paso;Univ Bath;Tongji Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2021
- 关键词：bioimaging fluorescent probes lysosomal pH senescence β -galactosidase
- Rigid and Photostable Shortwave Infrared Dye Absorbing/Emitting beyond 1200 nm for High-Contrast Multiplexed Imaging被引量：90收藏
- 作者：Wei, Ruwei Dong, Yan Wang, Xueli Li, Jin Lei, Zuhai Hu, Zhubin Chen, Jinquan Sun, Haitao Chen, Hao Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;East China Normal Univ;Fudan Univ;Chinese Acad Sci;East China Normal Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Bioimaging - Chlorine compounds - Infrared radiation
- Organocatalytic Enantioselective Direct Additions of Aldehydes to 4-Vinylpyridines and Electron-Deficient Vinylarenes and ThEIr Synthetic Applications被引量：87收藏
- 作者：Wang, Sinan Li, Xiangmin Liu, Hongwei Xu, Li Zhuang, Jinchen Li, Jian Li, Hao Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2015
- 关键词：Ethers - Synthesis (chemical) - Catalysis - Enantioselectivity - Chemical activation - Pyridine
- Prediction of Polypharmacological Profiles of Drugs by the Integration of Chemical, Side Effect, and Therapeutic Space被引量：83收藏
- 作者：Cheng, Feixiong Li, Weihua Wu, Zengrui Wang, Xichuan Zhang, Chen Li, Jie Liu, Guixia Tang, Yun
- 机构：E China Univ Sci & Technol;Shanghai MCC Hosp
- 来源：JOURNAL OF CHEMICAL INFORMATION AND MODELING 2013
- 关键词：ProtEIns - Tensors - Association reactions - Drug interactions
- First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated β-galactosidase被引量：76收藏
- 作者：Li, Xiaokang Qiu, Wenjing Li, Jinwen Chen, Xi Hu, Yulu Gao, Ying Shi, Donglei Li, Xinming Lin, Huiling Hu, Zelan Dong, Guoqiang Sheng, Chunquan Jiang, Bei Xia, Conglong Kim, Chu-Young Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Second Mil Med Univ;Dali Univ;Univ Texas El Paso
- 来源：CHEMICAL SCIENCE 2020
- 关键词：Probes - Fluorescence imaging - Enzymes - Fluorescence spectroscopy - Mammals
- A facile fluorescent probe with a large Stokes shift for sequentially detecting copper and sulfide in 100% aqueous solution and imaging them in living cells被引量：76收藏
- 作者：Wang, Huan Shi, Dong-Lei Li, Jin Tang, Hao-Yang Li, Jian Guo, Yuan
- 机构：Northwest Univ;Xian Univ Posts & Telecommun;East China Univ Sci & Technol
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2018
- 关键词：Copper ions Hydrogen sulfide Fluorescent imaging Large Stokes shift Pure water system
- A Strategy Enabling Enantioselective Direct Conjugate Addition of Inert Aryl Methane Nucleophiles to Enals with a Chiral Amine Catalyst under Mild Conditions被引量：67收藏
- 作者：Li, Tengfei Zhu, Jin Wu, Deyan Li, Xiangmin Wang, Sinan Li, Hao Li, Jian Wang, Wei
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2013
- 关键词：aryl methane enals iminium catalysis Michael addition organocatalysis
- A Fluorogenic ONOO--Triggered Carbon Monoxide Donor for Mitigating Brain Ischemic Damage被引量：64收藏
- 作者：Xing, Linfeng Wang, Bin Li, Jin Guo, Xinjian Lu, Xicun Chen, Xiaohua Sun, Haitao Sun, Zhenrong Luo, Xiao Qi, Suhua Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;Xuzhou Med Univ;Xuzhou Med Univ;East China Normal Univ;East China Normal Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Cell death
- A novel colorimetric and ratiometric fluorescent probe for selective detection of bisulfite in real samples and living cells被引量：52收藏
- 作者：Li, Jin Gao, Ying Guo, Haoran Li, Xiaokang Tang, Haoyang Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Xian Univ Posts & Telecommun
- 来源：DYES AND PIGMENTS 2019
- 关键词：Colorimetric and ratiometric Fluorescent probe Bisulfite Real samples Live-cell imaging
- Selective visualization of live-cell mitochondrial thiophenols and thEIr induced oxidative stress process by a rationally designed rhodol-based fluorescent probe被引量：52收藏
- 作者：Liu, Qimeng Li, Anyang Li, Xiaokang Li, Bin Zhang, Yanhui Li, Jian Guo, Yuan
- 机构： Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education; State Key Laboratory of Bioreactor Engineering; Key Laboratory of Resource Biology and Biotechnology in Western China of the Ministry of Education
- 来源：Sensors and Actuators, B: Chemical 2019
- 关键词：Fluorescence imaging - Oxidative stress - Lanthanum compounds - Oxygen - Fluorescence spectroscopy - Cytology - Mitochondria
- A ratiometric near-infrared fluorescence strategy based on spiropyran in situ switching for tracking dynamic changes of live-cell lysosomal pH被引量：49收藏
- 作者：Li, Jin Li, Xiaokang Jia, Jianbo Chen, Xi Lv, Yinjuan Guo, Yuan Li, Jian
- 机构：Northwest Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2019
- 关键词：Ratiometric sensing NIR fluorescent probe Spiropyran Fluorescence imaging Lysosomal pH
- Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold被引量：47收藏
- 作者：Xie, Yanan Wu, Xiaowei Li, Chunpu Wang, Jiang Li, Jian Liu, Hong
- 机构：East China Univ Sci & Technol;Chinese Acad Sci;Univ Chinese Acad Sci
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2017
- 关键词：Ruthenium compounds - Catalysis - Redox reactions - Hydrocarbons - Scaffolds - Chemical activation
- Curcumin-based polarity fluorescent probes: Design strategy and biological applications被引量：41收藏
- 作者：Hu, Linghao Shi, Donglei Li, Xinming Zhu, Jin Mao, Fei Li, Xiaokang Xia, Conglong Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：DYES AND PIGMENTS 2020
- 关键词：Curcumin Polarity-specificity Polarity fluorescent probe Lysosome Live-cell imaging Design strategy
- Spiropyran in Situ Switching: A Real-Time Fluorescence Strategy for Tracking DNA G-Quadruplexes in Live Cells被引量：37收藏
- 作者：Li, Jin Yin, Xinchi Li, Bin Li, Xiaokang Pan, Yuanjiang Li, Jian Guo, Yuan
- 机构：Northwest Univ;Zhejiang Univ;East China Univ Sci & Technol
- 来源：ANALYTICAL CHEMISTRY 2019
- 关键词：Cytology - Fluorescence imaging - Cells - Diagnosis - Red Shift
- A senolysis-based theragnostic prodrug strategy towards chronic renal failure被引量：35收藏
- 作者：Song, Yihe Li, Xinming Shi, Donglei Sun, Tianyue Liu, Wenwen Li, Xiaokang Qiao, Sicong Chen, Xin Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Hainan Univ;Tongji Univ;Dali Univ
- 来源：CHEMICAL SCIENCE 2022
- 关键词：Mammals
- Stress response decay with aging visualized using a dual-channel logic-based fluorescent probe被引量：34收藏
- 作者：Tian, Jingye Shi, Donglei Zhang, Yanhui Li, Xiaokang Li, Xinming Teng, Hao James, Tony D. Li, Jian Guo, Yuan
- 机构：Northwest Univ;East China Univ Sci & Technol;Univ Bath
- 来源：CHEMICAL SCIENCE 2021
- 关键词：Chlorine compounds - Computer circuits - Probes
- Lysosomal polarity increases with aging as revealed by a lysosome- targetable near -infrared fluorescent probe被引量：34收藏
- 作者：Shi, Donglei Hu, Linghao Li, Xinming Liu, Wenwen Gao, Ying Li, Xiaokang Jiang, Bei Xia, Conglong Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ
- 来源：SENSORS AND ACTUATORS B-CHEMICAL 2020
- 关键词：Fluorescence spectroscopy - Cytology - Infrared devices - Probes - Fluorescence
- Melting Point Distribution Analysis of Globally Approved and Discontinued Drugs: A Research for Improving the Chance of Success of Drug Design and Discovery被引量：32收藏
- 作者：Mao, Fei Kong, Qingya Ni, Wei Xu, Xiang Ling, Dazheng Lu, Zhengyu Li, Jian
- 机构：East China Univ Sci & Technol
- 来源：CHEMISTRYOPEN 2016
- 关键词：approved drugs discontinued drugs drug design and discovery drug-like properties Lipinskis rule of five melting point distribution
- Design, Synthesis and Therapeutic Evaluation of Novel Antimalarial Derivatives Based on the Clinical Antitumor Candidate Drug Quisinostat被引量：32收藏
- 作者：Li, Jian Song, Jiamei Li, Ruoxi Huang, Zhenghui Qian, Yunan Wang, Xicheng Shao, Qiqi Mao, Fei Wang, Manjiong Jiang, Lubin Li, Xiaokang
- 机构： State Key Laboratory of Bioreactor Engineering; Key Laboratory of Molecular Virology and Immunology; Key Laboratory of Xinjiang Phytomedicine Resource and Utilization; Key Laboratory of Tropical Biological Resources of Ministry of Education; Nanjing Advanced Academy of Life and Health
- 来源：SSRN 2024
- 关键词：Acetylation - Diseases - Electrophoresis - Structural optimization
- Direct oxidation of β-aryl substituted aldehydes to α,β-unsaturated aldehydes promoted by an o-anisidine-Pd(OAc) 2 Co-catalyst被引量：26收藏
- 作者：Liu, Jie Zhu, Jin Jiang, Hualiang Wang, Wei Li, Jian
- 机构： School of Pharmacy; Department of Chemistry and Chemical Biology; Drug Discovery and Design Center
- 来源：Chemistry - An Asian Journal 2009
- 关键词：Catalytic oxidation - Cost effectiveness - Palladium
- Hybrid nanocomposite multinetwork hydrogel containing magnesium hydroxide nanoparticles with enhanced antibacterial activity for wound dressing applications被引量：26收藏
- 作者：Qu, Jiahao Li, Jing Zhu, Weiping Xu, Yufang Zhou, Shengmin Yang, Yangyang Qian, Xuhong
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：POLYMER 2022
- 关键词：Mg(OH)(2) nanoparticles Nanocomposite hydrogel Antibacterial
- Targeting GRP75 with a Chlorpromazine Derivative Inhibits Endometrial Cancer Progression Through GRP75-IP3R-Ca2+-AMPK Axis被引量：20收藏
- 作者：Wang, Qi Li, Lijuan Gao, Xiaoyan Zhang, Chunxue Xu, Chen Song, Lingyi Li, Jian Sun, Xiao Mao, Fei Wang, Yudong
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2024
- 关键词：chlorpromazine endometrial cancer GRP75 MAM
- A rapid-response near-infrared fluorescent probe with a large Stokes shift for senescence-associated β-galactosidase activity detection and imaging of senescent cells被引量：19收藏
- 作者：Qiu, Wenjing Li, Xiaokang Shi, Donglei Li, Xinming Gao, Ying Li, Jinwen Mao, Fei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Northwest Univ;Dali Univ;East China Univ Sci & Technol
- 来源：DYES AND PIGMENTS 2020
- 关键词：Senescence-associated beta-galactosidase NIR fluorescent probe Aging Senescent cells Living-cell imaging
- A Senomorphlytic Three-Drug Combination Discovered in Salsola collina for Delaying Aging Phenotypes and Extending Healthspan被引量：15收藏
- 作者：Wang, Jiqun Liu, Wenwen Huang, Yunyuan Wang, Guangwei Guo, Xiaobo Shi, Donglei Sun, Tianyue Xiao, Chaojiang Zhang, Chao Jiang, Bei Guo, Yuan Li, Jian
- 机构：East China Univ Sci & Technol;Hainan Univ;Cent China Normal Univ;Northwest Univ;Dali Univ
- 来源：ADVANCED SCIENCE 2024
- 关键词：anti-aging drugs combination drugs salsola collina senomorphlytic activity
- Catalyst-free chemoselective α-sulfenylation/β-thiolation for α,β-unsaturated carbonyl compounds被引量：13收藏
- 作者：Huang, Xi Li, Juan Li, Xiang Wang, Jiayi Peng, Yanqing Song, Gonghua
- 机构：East China Univ Sci & Technol
- 来源：RSC ADVANCES 2019
- 关键词：Transition metals - Carbonyl compounds - Chemical reactions - Unsaturated compounds - Catalysts
- Antiaging Effects of Vicatia thibetica de Boiss Root Extract on Caenorhabditis elegans and Doxorubicin-Induced Premature Aging in Adult Mice被引量：11收藏
- 作者：Liu, Wenwen Guan, Yunhui Qiao, Sicong Wang, Jiqun Bao, Keting Mao, Zhifan Liao, Liang Moskalev, Alexey Jiang, Bei Zhu, Jin Xia, Conglong Li, Jian Hu, Zelan
- 机构：East China Univ Sci & Technol;Dali Univ;Russian Acad Sci;Dali Univ;Tongji Univ
- 来源：OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2021
- 关键词：Antioxidants - Free radicals - Plants (botany) - Heat resistance - Mammals
- Dihydro-Si-rhodamine for live-cell localization microscopy被引量：10收藏
- 作者：Zhang, Xiaodong Zhang, Mengmeng Yan, Yu Wang, Mingkang Li, Jin Yu, Yang Xiao, Yi Luo, Xiao Qian, Xuhong Yang, Youjun
- 机构：East China Univ Sci & Technol;Dalian Univ Technol;East China Normal Univ
- 来源：CHEMICAL COMMUNICATIONS 2021
- 关键词：Silicon - Fluorophores
- A Metal-free Approach to 3-Aryl-3-hydroxy-2-oxindoles by Treatment of 3-Acyloxy-2-oxindoles with Diaryliodonium Salts被引量：9收藏
- 作者：Li, Xiaokang Ni, Wei Mao, Fei Wang, Wei Li, Jian
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2016
- 关键词：3-acyloxy-2-oxindoles 3-aryl-3-hydroxy-2-oxindole arylation diaryliodonium salt metal-free
- Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes被引量：9收藏
- 作者：Li Hao Ji YaFei Li Jian Zhang ShiLei Yu ChenGuang Wang Wei
- 机构：Univ New Mexico;E China Univ Sci & Technol
- 来源：SCIENCE CHINA-CHEMISTRY 2010
- 关键词：organocatalysis alpha,beta-unsaturated aldehydes chiral fluorinated compounds Michael addition
