成果/Result
- Bioinspired trimodal macro/micro/nano-porous scaffolds loading rhBMP-2 for complete regeneration of critical size bone defect被引量：207收藏
- 作者：Tang, Wei Lin, Dan Yu, Yuanman Niu, Haoyi Guo, Han Yuan, Yuan Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACTA BIOMATERIALIA 2016
- 关键词：Trimodal macro/micro/nano-porous architecture Recombinant human bone morphogenetic protein-2 Critical size bone defect Mesoporous bioactive glass
- Improved osteogenesis and angiogenesis of magnesium-doped calcium phosphate cement via macrophage immunomodulation被引量：160收藏
- 作者：Wang, Meng Yu, Yuanman Dai, Kai Ma, Zhengyu Liu, Yang Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2016
- 关键词：Bone - Repair - Immune system - Tissue regeneration - Calcium phosphate - Magnesium compounds - Cements
- Sulfated chitosan rescues dysfunctional macrophages and accelerates wound healing in diabetic mice被引量：119收藏
- 作者：Shen, Tong Dai, Kai Yu, Yuanman Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACTA BIOMATERIALIA 2020
- 关键词：Inflammation Macrophages Transdifferentiation Wound healing Sulfated chitosan
- Calcium phosphate-based materials regulate osteoclast-mediated osseointegration被引量：82收藏
- 作者：Wang, Xiaogang Yu, Yuanman Ji, Luli Geng, Zhen Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2021
- 关键词：Calcium phosphate-based materials Osseointegration Osteoclast Bone regeneration
- Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration被引量：71收藏
- 作者：Tang, Wei Yu, Yuanman Wang, Jing Liv, Hui Pan, Haobo Wang, Guocheng Liu, Changsheng
- 机构：Chinese Acad Sci;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2020
- 关键词：Bone regeneration Mesoporous bioactive glass 2-N,6-O-sulfated chitosan Dual-modular Growth factor
- Manipulation of VEGF-induced angiogenesis by 2-N, 6-O-sulfated chitosan被引量：49收藏
- 作者：Yu, Yuanman Chen, Rui Sun, Yi Pan, Yuanzhong Tang, Wei Zhang, Shuang Cao, Lingyan Yuan, Yuan Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ACTA BIOMATERIALIA 2018
- 关键词：Sulfated chitosan Vascular endothelial growth factor Affinity Angiogenesis
- miR-21 promotes osseointegration and mineralization through enhancing both osteogenic and osteoclastic expression被引量：44收藏
- 作者：Geng, Zhen Yu, Yuanman Li, Zhaoyang Ma, Lili Zhu, Shengli Liang, Yanqin Cui, Zhenduo Wang, Jing Yang, Xianjin Liu, Changsheng
- 机构：East China Univ Sci & Technol;Tianjin Univ
- 来源：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2020
- 关键词：miR-21 Bone remodeling Bone mineralization Bonding strength Osseointegration
- Construction of developmentally inspired periosteum-like tissue for bone regeneration被引量：43收藏
- 作者：Dai, Kai Deng, Shunshu Yu, Yuanman Zhu, Fuwei Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BONE RESEARCH 2022
- Enhancement of VEGF-Mediated Angiogenesis by 2-N,6-O-Sulfated Chitosan-Coated Hierarchical PLGA Scaffolds被引量：41收藏
- 作者：Yu, Yuanman Chen, Jie Chen, Rui Cao, Lingyan Tang, Wei Lin, Dan Wang, Jing Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2015
- 关键词：Scaffold poly(lactic-co-glycolic acid) sulfated chitosan vascular endothelial growth factor angiogenesis
- 2-N, 6-O-sulfated chitosan-assisted BMP-2 immobilization of PCL scaffolds for enhanced osteoinduction被引量：40收藏
- 作者：Cao, Lingyan Yu, Yuanman Wang, Jing Werkmeister, Jerome A. McLean, Keith M. Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;CSIRO Mfg;Shanghai Jiao Tong Univ
- 来源：MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 2017
- 关键词：Electrospun Sulfated chitosan Bmp-2 Release Bioactivity
- A BMP-2-triggered in vivo osteo-organoid for cell therapy被引量：38收藏
- 作者：Dai, Kai Zhang, Qinghao Deng, Shunshu Yu, Yuanman Zhu, Fuwei Zhang, Shuang Pan, YuanZhong Long, Dandan Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：SCIENCE ADVANCES 2023
- 关键词：Bone - Cell culture - Flowcharting - Mammals - Proteins - Scaffolds (biology)
- The immunomodulatory role of sulfated chitosan in BMP-2-mediated bone regeneration被引量：32收藏
- 作者：Shu, Yang Yu, Yuanman Zhang, Shuang Wang, Jing Xiao, Yin Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Queensland Univ Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2018
- 关键词：Bone - Chitosan - Stem cells
- Enhancement of BMP-2-mediated angiogenesis and osteogenesis by 2-N,6-O-sulfated chitosan in bone regeneration被引量：32收藏
- 作者：Pan, Yuanzhong Chen, Jie Yu, Yuanman Dai, Kai Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2018
- 关键词：Biosynthesis - Bone - Proteins - Sulfur compounds
- Attenuating osteoarthritis by a high efficient anti-bone resorption injectable pH-responsive bisphosphonate-conjugated nano-apatite system被引量：31收藏
- 作者：Geng, Zhen Wang, Xiaogang Yu, Yuanman Ji, Luli Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMICAL ENGINEERING JOURNAL 2021
- 关键词：Osteoarthritis Subchondral bone remodeling Osteoclastic activity Bisphosphonate-conjugated nano-apatite pH-responsive
- Generation of rhBMP-2-induced juvenile ossicles in aged mice被引量：29收藏
- 作者：Dai, Kai Shen, Tong Yu, Yuanman Deng, Shunshu Mao, Lijie Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS 2020
- 关键词：Aging Bone regeneration rhBMP-2 Mesenchymal stromal cells Type H vessels
- Enhanced osteogenesis of bone morphology protein-2 in 2-N,6-O-sulfated chitosan immobilized PLGA scaffolds被引量：28收藏
- 作者：Kong, Xiangjun Wang, Jing Cao, Lingyan Yu, Yuanman Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES B-BIOINTERFACES 2014
- 关键词：Scaffold Surface modification Sulfated chitosan Bone morphology protein-2 Osteogenesis
- Tuning the bioactivity of bone morphogenetic protein-2 with surface immobilization strategies被引量：25收藏
- 作者：Chen, Rui Yu, Yuanman Zhang, Wenjing Pan, Yuanzhong Wang, Jing Xiao, Yin Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Queensland Univ Technol
- 来源：ACTA BIOMATERIALIA 2018
- 关键词：BMP-2 Osteogenic activity Immobilization Heparin Bone regeneration
- Preparation of pore EXPANDED mesoporous hydroxyapatite via auxiliary solubilizing template method被引量：22收藏
- 作者：Zeng, Fanyan Wang, Jing Wu, Yi Yu, Yuanman Tang, Wei Yin, Manli Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;E China Univ Sci & Technol
- 来源：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 2014
- 关键词：Mesoporous materials Hydroxyapatite Soft-tempalte Pore expanding agent Micelles
- Construction of cytokine reservoirs based on sulfated chitosan hydrogels for the capturing of VEGF in situ被引量：17收藏
- 作者：Wang, Chenmin Yu, Yuanman Chen, Han Zhang, Shuang Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2019
- 关键词：Sulfur compounds - Cell engineering - Scaffolds (biology) - Binding energy - Endothelial cells - Blood vessels - Hydrogels - Mammals - Chitosan - Histology
- y The regulatory role of sulfated polysaccharides in facilitating rhBMP-2-induced osteogenesis被引量：15收藏
- 作者：Chen, Han Yu, Yuanman Wang, Chenmin Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2019
- Engineering Neutrophil Immunomodulatory Hydrogels Promoted Angiogenesis被引量：15收藏
- 作者：Gao, Zehua Yu, Yuanman Dai, Kai Zhang, Tingting Ji, Luli Wang, Xuanlin Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS APPLIED MATERIALS & INTERFACES 2022
- 关键词：options. hydrogels neutrophils inflammation anastomosis angiogenesis
- Potentiation effect of HB-EGF on facilitating wound healing via 2-N, 6-O-sulfated chitosan nanoparticles modified PLGA scaffold被引量：12收藏
- 作者：Peng, Xiang Yu, Yuanman Wang, Zihao Zhang, Xiaohui Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：RSC ADVANCES 2017
- 关键词：Scaffolds (biology) - Chitosan
- Self-assembly of dual drug-delivery coating for synergistic bone regeneration被引量：11收藏
- 作者：Qu, Xue He, Fan Tan, Haoqi Yu, Yuanman Axrap, Akbar Wang, Meng Dai, Kai Zhang, Zheng Yang, Fei Wang, Shenguo Kohn, Joachim Liu, Changsheng
- 机构：E China Univ Sci & Technol;E China Univ Sci & Technol;Xinjiang Med Univ;Rutgers State Univ;Rutgers State Univ
- 来源：JOURNAL OF MATERIALS CHEMISTRY B 2016
- 关键词：Composite coatings - Targeted drug delivery - Controlled drug delivery - Self assembly - Nanoparticles - Recombinant proteins - Cytology - Bone
- Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction被引量：8收藏
- 作者：Wang, Shuang Xu, Chao Yu, Yuanman Li, Jie Chen, Tianwu Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Fudan Univ;Wuhan Text Univ
- 来源：BIOACTIVE MATERIALS 2025
- 关键词：Anterior cruciate ligament Scar tissue Macrophages Angiogenesis Osteogenesis
- Synergistic osteogenesis and angiogenesis in promoting bone repair by levistolide A-induced smad pathway activation被引量：7收藏
- 作者：Han, Zhengzhe Li, Ang Yu, Yuanman Dai, Kai Yin, Wenjing Li, Xiaolin Wang, Jing Yu, Min Qi, Xin Li, Qi
- 机构：Shanghai Jiao Tong Univ;East China Univ Sci & Technol;Shanghai Univ Tradit Chinese Med
- 来源：COMPOSITES PART B-ENGINEERING 2024
- 关键词：Bone defects Levistolide a Osteogenesis Angiogenesis
- Engineering a favourable osteogenic microenvironment by heparin mediated hybrid coating assembly and rhBMP-2 loading被引量：5收藏
- 作者：Tan, Haoqi Wang, Honglei Chai, Yanjun Yu, Yuanman Hong, Hua Yang, Fei Qu, Xue Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：RSC ADVANCES 2017
- 关键词：Bone - Cell adhesion - Recombinant proteins - Hydroxyapatite - Nanoparticles - Biocompatibility - Cell engineering - Coatings - Tissue engineering
- Regulating the bioactivity of non-glycosylated recombinant human bone morphogenetic protein-2 to enhance bone regeneration被引量：4收藏
- 作者：Yu, Yuanman Chen, Rui Chen, Xinye Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2024
- 关键词：Recombinant human bone morphogenetic protein-2 Osteogenic activity Protein stability Sulfated polysaccharide
- Sulfated polysaccharides target RANK Lys97 to inhibit osteoclast differentiation and reverse osteoporosis被引量：1收藏
- 作者：Wang, Xiaogang Ji, Luli Yu, Yuanman Yu, Jiaze Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE BIOMEDICAL ENGINEERING 2026
- 关键词：Polysaccharides - Sulfur compounds
- Sulfated chitosan enhances BMP-2-mediated spinal fusion via skeletal stem cell rejuvenation in aging被引量：1收藏
- 作者：Wang, Xiaogang Huang, Dongao Ji, Luli Yu, Yuanman Zhu, Fuwei Wang, Jing Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOACTIVE MATERIALS 2025
- 关键词：Spinal fusion BMP-2 Osteoclast Sulfated chitosan Skeletal stem cell
- Bridging the Biotic-Abiotic Divide: Design Principles of Hydrogel Interfaces for Next-Generation Brain-Machine Implants被引量：0收藏
- 作者：Li, Yeyuan He, Zirui Chen, Xinye Pan, Lina Yu, Yuanman Liu, Changsheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ADVANCED MATERIALS TECHNOLOGIES 2026
- 关键词：bio-interfaces BMIs hydrogel design long-term BMIs stability neuro-electrode mechanical compliance
