郑高伟 收藏
( 任职于 生物工程学院)
生物化工专业：博士生导师/硕士生导师、微生物学专业：硕士生导师、生物化学与分子生物学专业：硕士生导师、生物工程领域：工程硕士生导师 博士，副研究员。2005年本科毕业于四川大学，2011年获华东理工大学生物化工博士学位。现工作于华东理工大学生物工程学院，任生物反应器工程国家重点实验室副研究员，许建和教授团队主要成员之一，主要从事生物催化领域的研究工作，具体为新酶的筛选、新颖酶结构功能与催化机制研究、多酶催化体系的构建等。 目前1) 主持国家自然科学基金项目2项、“973”项目子课题、“863”计划子课题等项目3项；2)在国际重要学术期... 详细>>
- New opportunities for biocatalysis: driving the synthesis of chiral chemicals被引量：148收藏
- 作者：Zheng, Gao-Wei Xu, Jian-He
- 机构：E China Univ Sci & Technol
- 来源：CURRENT OPINION IN BIOTECHNOLOGY 2011
- 关键词：Stereochemistry - Biocatalysts - Biochemical engineering
- 质疑
- Recent progress on deep eutectic solvents in biocatalysis被引量：136收藏
- 作者：Xu, Pei Zheng, Gao-Wei Zong, Min-Hua Li, Ning Lou, Wen-Yong
- 机构：South China Univ Technol;South China Univ Technol;East China Univ Sci & Technol
- 来源：BIORESOURCES AND BIOPROCESSING 2017
- 关键词：Deep eutectic solvents Biocatalysis Catalysts Biodegradability Influence
- 质疑
- Whole-Cell Biocatalytic Processes with Ionic Liquids被引量：132收藏
- 作者：Xu, Pei Zheng, Gao-Wei Du, Peng-Xuan Zong, Min-Hua Lou, Wen-Yong
- 机构： State Key Laboratory of Pulp and Paper Engineering; State Key Laboratory of Bioreactor Engineering; Laboratory of Applied Biocatalysis
- 来源：ACS Sustainable Chemistry and Engineering 2016
- 关键词：Catalysis - Cells - Cytology - Biodegradability - Ionic liquids - Enzymes
- 质疑
- Asymmetric Amination of Secondary Alcohols by using a Redox-Neutral Two-Enzyme Cascade被引量：112收藏
- 作者：Chen, Fei-Fei Liu, You-Yan Zheng, Gao-Wei Xu, Jian-He
- 机构：E China Univ Sci & Technol;Guangxi Univ;Guangxi Acad Sci
- 来源：CHEMCATCHEM 2015
- 关键词：amine dehydrogenase asymmetric catalysis biotransformations cascade reaction chiral amines
- 质疑
- Reshaping the Active Pocket of Amine Dehydrogenases for Asymmetric Synthesis of Bulky Aliphatic Amines被引量：102收藏
- 作者：Chen, Fei-Fei Zheng, Gao-Wei Liu, Lei Li, Hao Chen, Qi Li, Fu-Long Li, Chun-Xiu Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2018
- 关键词：amine dehydrogenase reductive amination chiral amine protein engineering biocatalysis substrate scope
- 质疑
- Development of an Engineered Ketoreductase with Simultaneously Improved Thermostability and Activity for Making a Bulky Atorvastatin Precursor被引量：101收藏
- 作者：Gong, Xu-Min Qin, Zhen Li, Fu-Long Zeng, Bu-Bing Zheng, Gao-Wei Xu, Jian-He
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2019
- 关键词：biocatalysis asymmetric reduction ketoreductase protein engineering thermostabilization atorvastatin precursor
- 质疑
- Preparation of Structurally Diverse Chiral Alcohols by Engineering Ketoreductase CgKR1被引量：82收藏
- 作者：Zheng, Gao-Wei Liu, Yuan-Yang Chen, Qi Huang, Lei Yu, Hui-Lei Lou, Wen-Yong Li, Chun-Xiu Bai, Yun-Peng Li, Ai-Tao Xu, Jian-He
- 机构：East China Univ Sci & Technol;South China Univ Technol;Max Planck Inst Kohlenforsch
- 来源：ACS CATALYSIS 2017
- 关键词：asymmetric reduction ketoreductase chiral alcohol protein engineering substrate specificity biocatalysis
- 质疑
- A Motif-Based Deep Learning Tool for the Identification of Unusual NADH-Dependent Imine Reductases被引量：73收藏
- 作者：Shen, Xin-Yuan Wu, Yu-Xuan Ma, Zhi-Feng Yi, Xiao Shi, Min Zhu, Zhen-Yu Jin, Tian Hu, Xiao-Yu Huang, Zi-Yi Gao, Yun-Fei Chen, Qi Yu, Hui-Qun Xu, Jian-He Fan, Gui-Sheng Zheng, Gao-Wei
- 机构： State Key Laboratory of Bioreactor Engineering; School of Information Science and Engineering
- 来源：SSRN 2025
- 关键词：Amination - Enzyme immobilization - Enzyme inhibition - Enzyme kinetics - Hydrolases - Lipases
- 质疑
- One-pot biocatalytic route from cycloalkanes to α,ω-dicarboxylic acids by designed Escherichia coli consortia被引量：68收藏
- 作者：Wang, Fei Zhao, Jing Li, Qian Yang, Jun Li, Renjie Min, Jian Yu, Xiaojuan Zheng, Gao-Wei Yu, Hui-Lei Zhai, Chao Acevedo-Rocha, Carlos G. Ma, Lixin Li, Aitao
- 机构：Hubei Univ;East China Univ Sci & Technol;East China Univ Sci & Technol;Biosyntia ApS
- 来源：NATURE COMMUNICATIONS 2020
- 质疑
- Enantioselective Synthesis of Chiral Vicinal Amino Alcohols Using Amine Dehydrogenases被引量：67收藏
- 作者：Chen, Fei-Fei Cosgrove, Sebastian C. Birmingham, William R. Mangas-Sanchez, Juan Citoler, Joan Thompson, Matthew P. Zheng, Gao-Wei Xu, Jian-He Turner, Nicholas J.
- 机构：East China Univ Sci & Technol;Univ Manchester;EnginZyme AB
- 来源：ACS CATALYSIS 2019
- 关键词：amine dehydrogenase biocatalysis chiral amino alcohols directed evolution reductive amination
- 质疑
- Efficient Synthesis of Chiral Indolines using an Imine Reductase from Paenibacillus lactis被引量：66收藏
- 作者：Li, Hao Luan, Zheng-Jiao Zheng, Gao-Wei Xu, Jian-He
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2015
- 关键词：asymmetric hydrogenation biocatalysis chiral indolines imine reductase 3H-indoles
- 质疑
- Chemical modulators for enzymatic reactions被引量：66收藏
- 作者：Xu, Jian-He Zheng, Gao-Wei Luo, Xiao-Jing
- 机构： Laboratory of Biocatalysis and Synthetic Biotechnology
- 来源：RSC Green Chemistry 2015
- 质疑
- Whole-Cell Biocatalytic Processes with Ionic Liquids被引量：61收藏
- 作者：Xu, Pei Zheng, Gao-Wei Du, Peng-Xuan Zong, Min-Hua Lou, Wen-Yong
- 机构：S China Univ Technol;E China Univ Sci & Technol;S China Univ Technol
- 来源：ACS SUSTAINABLE CHEMISTRY & ENGINEERING 2016
- 关键词：Whole-cell Ionic liquid Biocatalysis Biocompatibility Biodegradability
- 质疑
- Efficient Synthesis of a Chiral Precursor for Angiotensin-Converting Enzyme (ACE) Inhibitors in High Space-Time Yield by a New Reductase without External Cofactors被引量：61收藏
- 作者：Shen, Nai-Dong Ni, Yan Ma, Hong-Min Wang, Li-Juan Li, Chun-Xiu Zheng, Gao-Wei Zhang, Jie Xu, Jian-He
- 机构：E China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2012
- 质疑
- One-Pot Enzyme Cascade for Controlled Synthesis of Furancarboxylic Acids from 5-Hydroxymethylfurfural by H2O2 Internal Recycling被引量：58收藏
- 作者：Jia, Hao-Yu Zong, Min-Hua Zheng, Gao-Wei Li, Ning
- 机构：South China Univ Technol;East China Univ Sci & Technol
- 来源：CHEMSUSCHEM 2019
- 关键词：biocatalysis biomass dehydrogenases heterocycles oxidases
- 质疑
- Stereospecific Reduction of Methyl o-Chlorobenzoylformate at 300 g?L-1 without Additional Cofactor using a Carbonyl Reductase Mined from Candida glabrata被引量：57收藏
- 作者：Ma, Hongmin Yang, Linlin Ni, Yan Zhang, Jie Li, Chun-Xiu Zheng, Gao-Wei Yang, Huaiyu Xu, Jian-He
- 机构：E China Univ Sci & Technol;Chinese Acad Sci
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2012
- 关键词：bioinformatics biotransformations cofactors oxidoreductases
- 质疑
- Identification of an Imine Reductase for Asymmetric Reduction of Bulky Dihydroisoquinolines被引量：56收藏
- 作者：Li, Hao Tian, Ping Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ORGANIC LETTERS 2017
- 质疑
- Discovery of an Imine Reductase for Reductive Amination of Carbonyl Compounds with Sterically Challenging Amines被引量：54收藏
- 作者：Chen, Fei-Fei He, Xue-Feng Zhu, Xin-Xin Zhang, Zhi Shen, Xin-Yuan Chen, Qi Xu, Jian-He Turner, Nicholas J. Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Univ Manchester
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Carbonyl compounds - Nucleophiles - Substrates - Synthesis (chemical)
- 质疑
- Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregata被引量：53收藏
- 作者：Zhang, Chen-Sheng Zhang, Zhi-Jun Li, Chun-Xiu Yu, Hui-Lei Zheng, Gao-Wei Xu, Jian-He
- 机构：E China Univ Sci & Technol
- 来源：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 2012
- 关键词：Nitrilase Labrenzia aggregate Enantioselective hydrolysis (R)-o-Chloromandelic acid Biphasic system
- 质疑
- Enzymatic Production of l-Menthol by a High Substrate Concentration Tolerable Esterase from Newly Isolated Bacillus subtilis ECU0554被引量：48收藏
- 作者：Zheng, Gao-Wei Yu, Hui-Lei Zhang, Jian-Dong Xu, Jian-He
- 机构：E China Univ Sci & Technol
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2009
- 关键词：Bacillus subtilis esterase enzyme catalysis high substrate concentration tolerance hydrolysis l-menthol dl-menthyl acetate
- 质疑
- Rational Engineering of Formate Dehydrogenase Substrate/Cofactor Affinity for Better Performance in NADPH Regeneration被引量：46收藏
- 作者：Jiang, He-Wen Chen, Qi Pan, Jiang Zheng, Gao-Wei Xu, Jian-He
- 机构：East China Univ Sci & Technol
- 来源：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY 2020
- 关键词：Binding affinity Burkholderia stabilis Formate dehydrogenase NADPH regeneration Rational engineering
- 质疑
- Development of an engineered thermostable amine dehydrogenase for the synthesis of structurally diverse chiral amines被引量：44收藏
- 作者：Liu, Lei Wang, Dong-Hao Chen, Fei-Fei Zhang, Zhi-Jun Chen, Qi Xu, Jian-He Wang, Zhi-Long Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：CATALYSIS SCIENCE & TECHNOLOGY 2020
- 关键词：Ammonia - Amino acids - Amines
- 质疑
- Asymmetric Reductive Amination of Structurally Diverse Ketones with Ammonia Using a Spectrum-Extended Amine Dehydrogenase被引量：41收藏
- 作者：Wang, Dong-Hao Chen, Qi Yin, Sai-Nan Ding, Xu-Wei Zheng, Yu-Cong Zhang, Zhi Zhang, Yu-Hui Chen, Fei-Fei Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ACS CATALYSIS 2021
- 关键词：< em > reductive amination < em > < em > amine dehydrogenase < em > < em > protein engineering < em > < em > substrate scope < em > < em > chiral amine < em >
- 质疑
- Efficient production of succinic acid in engineered Escherichia coli strains controlled by anaerobically-induced nirB promoter using sweet potato waste hydrolysate被引量：36收藏
- 作者：Huang, Meihua Cheng, Jie Chen, Peng Zheng, Gaowei Wang, Dan Hu, Yuanliang
- 机构：Chongqing Univ;East China Univ Sci & Technol;Hubei Normal Univ
- 来源：JOURNAL OF ENVIRONMENTAL MANAGEMENT 2019
- 关键词：Anaerobically-induced nirB promoter Sweet potato waste Succinic acid Engineered Escherichia coil
- 质疑
- Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases被引量：35收藏
- 作者：Zhang, Yu-Hui Chen, Fei-Fei Li, Bo-Bo Zhou, Xin-Yi Chen, Qi Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2020
- 质疑
- Evolution of Glucose Dehydrogenase for Cofactor Regeneration in Bioredox Processes with Denaturing Agents被引量：35收藏
- 作者：Qian, Wen-Zhuo Ou, Ling Li, Chun-Xiu Pan, Jiang Xu, Jian-He Chen, Qi Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol
- 来源：CHEMBIOCHEM 2020
- 关键词：biocatalysis chemical stability cofactor regeneration directed evolution glucose dehydrogenase
- 质疑
- Efficient production of l-menthol in a two-phase system with SDS using an immobilized bacillus subtilis esterase被引量：32收藏
- 作者：Pan, Jiang Dang, Ngoc-Duy Zheng, Gao-Wei Cheng, Bo Ye, Qin Xu, Jian-He
- 机构： Laboratory of Biocatalysis and Synthetic Biotechnology; Sunflower Pharmaceutical Group Company Limited
- 来源：Bioresources and Bioprocessing 2014
- 关键词：Cloning - Crosslinking - Enantioselectivity - Enzymatic hydrolysis - Enzyme activity - Enzyme inhibition - Esters - Sulfur compounds
- 质疑
- Efficient production of (R)-o-chloromandelic acid by deracemization of o-chloromandelonitrile with a new nitrilase mined from Labrenzia aggregata被引量：32收藏
- 作者：Zhang, Chen-Sheng Zhang, Zhi-Jun Li, Chun-Xiu Yu, Hui-Lei Zheng, Gao-Wei Xu, Jian-He
- 机构： Laboratory of Biocatalysis and Synthetic Biotechnology
- 来源：Applied Microbiology and Biotechnology 2012
- 关键词：Data mining - Hydrolysis - Lanthanum compounds - Enantioselectivity
- 质疑
- Reductive Amination of Biobased Levulinic Acid to Unnatural Chiral γ-Amino Acid Using an Engineered Amine Dehydrogenase被引量：32收藏
- 作者：Cai, Rui-Feng Liu, Lei Chen, Fei-Fei Li, Aitao Xu, Jian-He Zheng, Gao-Wei
- 机构：East China Univ Sci & Technol;Hubei Univ;East China Univ Sci & Technol
- 来源：ACS SUSTAINABLE CHEMISTRY & ENGINEERING 2020
- 关键词：biomass reductive amination amine dehydrogenase directed evolution unnatural gamma-amino acid (S)-4-aminopentanoic acid
- 质疑
- Highly efficient bioreduction of 2-hydroxyacetophenone to (S)- and (R)-1-phenyl-1,2-ethanediol by two substrate tolerance carbonyl reductases with cofactor regeneration被引量：32收藏
- 作者：Cui, Zhi-Mei Zhang, Jian-Dong Fan, Xiao-Jun Zheng, Gao-Wei Chang, Hong-Hong Wei, Wen-Long
- 机构：Taiyuan Univ Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF BIOTECHNOLOGY 2017
- 关键词：Highly enantioselective Carbonyl reductase 2-Hydroxyacetophenone Chiral 1-phenyl-1,2-ethanediol Cofactor regeneration
- 质疑
