成果/Result
- Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides被引量：163收藏
- 作者：Wu, Yueming Zhang, Danfeng Ma, Pengcheng Zhou, Ruiyi Hua, Lei Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：NATURE COMMUNICATIONS 2018
- Therapeutic strategies against bacterial biofilms被引量：139收藏
- 作者：Bi, Yufang Xia, Guixue Shi, Chao Wan, Jianglin Liu, Longqiang Chen, Yuan Wu, Yueming Zhang, Wenjing Zhou, Min He, Hongyan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：FUNDAMENTAL RESEARCH 2021
- 关键词：Antimicrobial resistance Biofilm Persister cell Nanomaterials Drug delivery
- Recent Advances and Future Developments in the Preparation of Polypeptides via N-Carboxyanhydride (NCA) Ring-Opening Polymerization被引量：68收藏
- 作者：Wu, Yueming Chen, Kang Wang, Jiangzhou Chen, Minzhang Dai, Wenhui Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2024
- Heterochiral β-Peptide Polymers Combating Multidrug-Resistant Cancers Effectively without Inducing Drug Resistance被引量：67收藏
- 作者：Shao, Ning Yuan, Ling Ma, Pengcheng Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Xiao, Guohui Fei, Jian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2022
- 关键词：Diseases - Biocompatibility - Cancer cells - Tumors
- Water-Insensitive Synthesis of Poly-β-Peptides with Defined Architecture被引量：66收藏
- 作者：Zhou, Min Xiao, Ximian Cong, Zihao Wu, Yueming Zhang, Wenjing Ma, Pengcheng Chen, Sheng Zhang, Haodong Zhang, Danfeng Zhang, Donghui Luan, Xiangfeng Mai, Yiyong Liu, Runhui
- 机构：East China Univ Sci & Technol;Shanghai Jiao Tong Univ
- 来源：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 2020
- 关键词：polymerization poly-beta-peptides secondary structure water-insensitive polymerization beta-NTA
- A dual-targeting antifungal is effective against multidrug-resistant human fungal pathogens被引量：61收藏
- 作者：Zhou, Min Liu, Longqiang Cong, Zihao Jiang, Weinan Xiao, Ximian Xie, Jiayang Luo, Zhengjie Chen, Sheng Wu, Yueming Xue, Xinying Shao, Ning Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Capital Med Univ;Shandong Second Med Univ
- 来源：NATURE MICROBIOLOGY 2024
- Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization on N-Carboxyanhydride被引量：53收藏
- 作者：Chen, Kang Wu, Yueming Chen, Minzhang Wang, Jiangzhou Zhou, Min Chen, Xin Liu, Runhui
- 机构： State Key Laboratory of Bioreactor Engineering; Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism; Department of Biomaterials and Stem Cells; Key Laboratory for Ultrafine Materials
- 来源：ACS Central Science 2025
- 关键词：Carboxylation - Cationic polymerization - Organocatalyst - Reaction intermediates - Reaction rates - Ring opening polymerization
- Antimicrobial Properties and Application of Polysaccharides and Their Derivatives被引量：51收藏
- 作者：Xia, Gui-Xue Wu, Yue-Ming Bi, Yu-Fang Chen, Kang Zhang, Wei-Wei Liu, Shi-Qi Zhang, Wen-Jing Liu, Run-Hui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF POLYMER SCIENCE 2021
- 关键词：Antimicrobial Drug resistance Polysaccharides Polysaccharide derivatives Chitosan
- Peptide-Mimicking Poly(2-oxazoline)s Possessing Potent Antifungal Activity and BBB Penetrating Property to Treat Invasive Infections and Meningitis被引量：47收藏
- 作者：Jiang, Weinan Zhou, Min Chen, Sheng Xie, Jiayang Chen, Minzhang Zhang, Haodong Wu, Yueming Chen, Xin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2023
- 关键词：Antifungal agents - Drug interactions - Mammals - Peptides
- Peptide polymer displaying potent activity against clinically isolated multidrug resistant Pseudomonas aeruginosa in vitro and in vivo被引量：41收藏
- 作者：Jiang, Weinan Xiao, Ximian Wu, Yueming Zhang, Weiwei Cong, Zihao Liu, Jingjing Chen, Sheng Zhang, Haodong Xie, Jiayang Deng, Shuai Chen, Minzhang Wang, Yun Shao, Xiaoyan Dai, Yidong Sun, Yun Fei, Jian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Ruijin Rehabil Hosp;Shanghai Jiao Tong Univ
- 来源：BIOMATERIALS SCIENCE 2020
- 关键词：Antimicrobial agents - Bacteria - Antibiotics - Lithium compounds - Network security
- Reversing Anticancer Drug Resistance by Synergistic Combination of Chemotherapeutics and Membranolytic Antitumor β-Peptide Polymer被引量：27收藏
- 作者：Shao, Ning Yuan, Ling Liu, Longqiang Cong, Zihao Wang, Jiangzhou Wu, Yueming Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2024
- 关键词：Cancer cells - Cells - Chemotherapy - Diseases
- Synthesis of poly-α/β-peptides with tunable sequence via the copolymerization on N-carboxyanhydride and N-thiocarboxyanhydride被引量：27收藏
- 作者：Zhou, Min Zou, Jingcheng Liu, Longqiang Xiao, Ximian Deng, Shuai Wu, Yueming Xie, Jiayang Cong, Zihao Ji, Zhemin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：ISCIENCE 2021
- A Polymeric Strategy Empowering Vascular Cell Selectivity and Potential Application Superior to Extracellular Matrix Peptides被引量：26收藏
- 作者：Zhou, Ruiyi Wu, Yueming Chen, Kang Zhang, Deteng Chen, Qi Zhang, Donghui She, Yunrui Zhang, Wenjing Liu, Longqiang Zhu, Yueqi Gao, Changyou Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Zhejiang Univ;Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6;Soochow Univ
- 来源：ADVANCED MATERIALS 2022
- 关键词：EC-selective biomaterials endothelialization polymeric strategies vascular stents beta-peptide polymers
- Statistic Copolymers Working as Growth Factor-Binding Mimics of Fibronectin被引量：23收藏
- 作者：Zhang, Wenjing Wu, Yueming Chen, Qi Zhang, Haodong Zhou, Min Chen, Kang Cao, Chuntao Guo, Han Xu, Jianrong Liu, Honglai Lin, Haodong Liu, Changsheng Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Shanghai Univ Tradit Chinese Med;East China Univ Sci & Technol
- 来源：ADVANCED SCIENCE 2022
- 关键词：fibronectin mimicking growth factor binding statistic copolymers
- Host defense peptide-mimicking peptide polymer-based antibacterial hydrogel enables efficient healing of MRSA-infected wounds被引量：19收藏
- 作者：Qiao, Zhongqian Zhang, Wenjing Wu, Yueming Jiang, Weinan Shao, Ning Xie, Jiayang Xia, Guixue Chen, Qimeng Liu, Zhefeng Zou, Jingcheng Gu, Jiawei Luan, Shifang Lin, Haodong Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Chinese Acad Sci
- 来源：SCIENCE CHINA-CHEMISTRY 2023
- 关键词：peptide polymer wound healing MRSA drug-resistance host defense peptide
- Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture被引量：19收藏
- 作者：Ma, Pengcheng Wu, Yueming Jiang, Weinan Shao, Ning Zhou, Min Chen, Yuan Xie, Jiayang Qiao, Zhongqian Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：BIOMATERIALS SCIENCE 2022
- 关键词：Antibiotics - Aquaculture - Bacteria - Biodegradable polymers - Disease control
- Efficient synthesis of amino acid polymers for protein stabilization被引量：17收藏
- 作者：Li, Bing Wu, Yueming Zhang, Wenjing Zhang, Si Shao, Ning Zhang, Weiwei Zhang, Lixin Fei, Jian Dai, Yidong Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol;Shanghai Jiao Tong Univ;Shanghai Ruijin Rehabil Hosp
- 来源：BIOMATERIALS SCIENCE 2019
- 关键词：Biosynthesis - High resolution transmission electron microscopy - Ring opening polymerization - Stabilization - Lithium compounds - Proteins - Dynamic light scattering - Phase locked loops
- A host defense peptide-mimicking prodrug activated by drug-resistant Gram-negative bacterial infections被引量：17收藏
- 作者：Xie, Jiayang Zhou, Min Cong, Zihao Xiao, Ximian Liu, Longqiang Chen, Sheng Jiang, Weinan Wu, Yueming Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：SCIENCE TRANSLATIONAL MEDICINE 2025
- Controllable Polymerization of N-Substituted β-Alanine N-Thiocarboxyanhydrides for Convenient Synthesis of Functional Poly(β-peptoid)s被引量：13收藏
- 作者：Xiao, Ximian Zhou, Min Cong, Zihao Liu, Longqiang Zou, Jingcheng Ji, Zhemin Cui, Ruxin Wu, Yueming Zhang, Haodong Chen, Sheng Li, Maoquan Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Tongji Univ
- 来源：CCS CHEMISTRY 2023
- 关键词：ring-opening polymerization poly(beta-peptoid) beta-NNTA functionlization
- Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing被引量：13收藏
- 作者：Zhang, Haodong Liang, Qian Ji, Yanxiu Chen, Qi Jiang, Weinan Zhang, Donghui Wu, Yueming Yu, Liangmin Chen, Wei Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;Fudan Univ;Ocean Univ China
- 来源：BIOACTIVE MATERIALS 2025
- 关键词：Antioxidative Antibacterial Hydrogel films Infected diabetic wound healing Wound dressing
- Peptide-mimicking poly(2-oxazoline) displaying potent antibacterial and antibiofilm activities against multidrug-resistant Gram-positive pathogenic bacteria被引量：12收藏
- 作者：Cong, Zihao Yan, Zi Xiao, Ximian Liu, Longqiang Luo, Zhengjie Zou, Jingcheng Chen, Minzhang Wu, Yueming Zhou, Min Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 2025
- 关键词：Poly(2-oxazoline)s Host defense peptide Antibiofilm MRSA Drug-resistance
- Open-vessel polymerization of N-carboxyanhydride (NCA) for polypeptide synthesis被引量：11收藏
- 作者：Wu, Yueming Chen, Kang Wang, Jiangzhou Dai, Wenhui Yu, Haowen Xie, Xinyi Chen, Minzhang Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：NATURE PROTOCOLS 2025
- Synergistic Combination of Biodegradable Peptide Polymer and Curcumin as Promising Antibiotic Substitution in Aquaculture to Alleviate the Global Challenge of Antimicrobial Resistance被引量：11收藏
- 作者：Ma, Pengcheng Chen, Yuan Shao, Ning Zhang, Junyu Wu, Yueming Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHINESE JOURNAL OF CHEMISTRY 2022
- 关键词：Antimicrobial polymer Aquaculture Peptides Antibiotics Biological activity
- Advance and Designing Strategies in Polymeric Antifungal Agents Inspired by Membrane-Active Peptides被引量：10收藏
- 作者：Jiang, Weinan Wu, Yueming Zhou, Min Song, Gonghua Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2022
- 关键词：antifungal polymer cell-penetrating peptides drug resistance host defense peptides peptidomimetics
- Self-Assembled Poly(sarcosine) Functionalized Host Defense Peptide-Mimicking Poly-β-Peptides for Combating Drug-Resistant Fungal Infection被引量：7收藏
- 作者：Xie, Jiayang Liu, Zhefeng Zhou, Min Luo, Zhengjie Liu, Longqiang Xiao, Ximian Jiang, Weinan Hu, Weilong Wu, Yueming Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：ADVANCED FUNCTIONAL MATERIALS 2025
- 关键词：antifungal host defense peptide mimic poly(sarcosine) functionalized poly-beta-peptides self-assembly
- Controlled copolymerization of α-NCAs and α-NNTAs for preparing peptide/peptoid hybrid polymers with adjustable proteolysis被引量：7收藏
- 作者：Zou, Jingcheng Zhou, Min Ji, Zhemin Xiao, Ximian Wu, Yueming Cui, Ruxin Deng, Shuai Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：POLYMER CHEMISTRY 2022
- 关键词：Amino acids - Biocompatibility - Copolymerization - Proteolysis - Synthesis (chemical)
- Therapeutic strategies against bacterial biofilms被引量：7收藏
- 作者：Yufang Bi Guixue Xia Chao Shi Jianglin Wan Longqiang Liu Yuan Chen Yueming Wu Wenjing Zhang Min Zhou Hongyan He Runhui Liu
- 机构：State Key Laboratory of Bioreactor Engineering;Frontiers Science Center for Materiobiology and Dynamic Chemistry
- 来源：自然科学基础研究（英文版） 2021
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- Single-Center Trifunctional Organocatalyst Enables Fast and Controlled Polymerization on N-Carboxyanhydride被引量：6收藏
- 作者：Chen, Kang Wu, Yueming Chen, Minzhang Wang, Jiangzhou Zhou, Min Chen, Xin Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci;East China Univ Sci & Technol
- 来源：ACS CENTRAL SCIENCE 2024
- 基于HDP模拟聚合物与利福平协同组合的口服脂质体治疗水产养殖细菌感染被引量：4收藏
- 作者：Yu, Haowen Chen, Luhang Wu, Yueming Dai, Wenhui Chen, Minzhang Chen, Yuan Liu, Longqiang Wang, Jiangzhou Huang, Xinqi Chen, Kang Liu, Runhui
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Chinese Acad Sci
- 来源：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Frontiers Sci Ctr Materiobiol & Dynam Chem, Engn Res Ctr Biomed Mat,Minist Educ,Key Lab Ultraf, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Dept Biomat & Stem Cells, Suzhou 215163, Peoples R China 2025
- 氨基酸聚合物用于提高冻干过程中蛋白稳定性的研究被引量：4收藏
- 作者：李冰 丛自豪 肖希勉 武月铭 刘润辉
- 机构：华东理工大学生物反应器工程国家重点实验室
- 来源：《华东理工大学学报（自然科学版）》 2020
- 关键词：氨基酸聚合物 NCA聚合 蛋白稳定性 半乳糖苷酶 冻干
- 摘要：为提高蛋白在冻干过程中的稳定性,采用双(三甲基硅基)氨基锂(LiHMDS)引发的超快速氨基酸环内酸酐(NCA)开环聚合方法,制备了聚L-赖氨酸(PLL)均聚物和聚L-谷氨酸(PLG)均聚物。以β-半乳糖苷酶(β-Gal)...
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