冀亚飞 收藏
( 任职于 药学院制药工程系)
多年来国内外发表论文140余篇，获得中国发明专利授权10项，获省部级科技进步奖3项，上海市教学一等奖1项，校级奖项2项。担任制药工程系制药工艺学责任教授，受邀作为精细化工，应用化学，Research on Chemical Intermediates,Synthetic Communications, Catalysis Letters, Fuel Processing Technology等国内外刊物的审稿人；受邀作为国家自然科学基金委评议人。有多个药物合成工艺在企业得到应用，具有知识产权的新一代甲氧苄啶、甲乙基香兰素绿色技术居于领先水平。承担重大应用课题、国家自然科学基金、博士点基金等... 详细>>
- Palladium-catalyzed direct mono -aroylation of O -arylmethyl and aryl-substituted acetoxime ethers被引量：96收藏
- 作者：Shao, Ling-Yan Xu, Zhi Wang, Cun-Ying Fu, Xiao-Pan Chen, Miao-Miao Liu, Hong-Wei Ji, Ya-Fei
- 机构： School of Pharmacy; School of Chemical Engineering and Technology
- 来源：Organic and Biomolecular Chemistry 2018
- 关键词：Catalysis - Organometallics - Ketones - Palladium
- 质疑
- Interplay of Direct Stereocontrol and Dynamic Kinetic Resolution in a Bifunctional Amine Thiourea Catalyzed Highly Enantioselective Cascade Michael-Michael Reaction被引量：69收藏
- 作者：Yu, Chenguang Zhang, Yinan Song, Aiguo Ji, Yafei Wang, Wei
- 机构：Univ New Mexico;Beijing Univ Chem Technol;E China Univ Sci & Technol;Chinese Acad Sci
- 来源：CHEMISTRY-A EUROPEAN JOURNAL 2011
- 关键词：amine thioureas cascade catalysis dynamic kinetic resolution organocatalysis tetrahydrothiophenes
- 质疑
- Metal-free directed C-H borylation of 2-(N-methylanilino)-5-fluoropyridines and 2-benzyl-5-fluoropyridines被引量：60收藏
- 作者：Wu, Gaorong Xu, Xiaobo Wang, Shuai Chen, Lu Pang, Binghan Ma, Tao Ji, Yafei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Univ Chinese Med
- 来源：CHINESE CHEMICAL LETTERS 2022
- 关键词：Metal-free C-H borylation 2-(N-Methylanilino)-5-fluoropyridines 2-Benzyl-5-fluoropyridines BBr3
- 质疑
- Diastereo- and Enantioselective Organocatalytic Direct Conjugate Addition of γ-Butenolide to Chalcones被引量：56收藏
- 作者：Zhang, Yinan Yu, Chenguang Ji, Yafei Wang, Wei
- 机构：E China Univ Sci & Technol;Univ New Mexico;Chinese Acad Sci
- 来源：CHEMISTRY-AN ASIAN JOURNAL 2010
- 关键词：enones lactones Michael addition organocatalysis thioureas
- 质疑
- Cu(OAc)2-catalyzed remote benzylic C(sp3)-H oxyfunctionalization for C=O formation directed by the hindered para-hydroxyl group with ambient air as the terminal oxidant under ligand- and additive-free conditions被引量：44收藏
- 作者：Jiang, Jian-An Chen, Cheng Huang, Jian-Gang Liu, Hong-Wei Cao, Song Ji, Ya-Fei
- 机构：E China Univ Sci & Technol
- 来源：GREEN CHEMISTRY 2014
- 质疑
- Concurrent synthesis of vanillin and isovanillin被引量：42收藏
- 作者：Huang, Wei-Bin Du, Cai-Yan Jiang, Jian-An Ji, Ya-Fei
- 机构：E China Univ Sci & Technol
- 来源：RESEARCH ON CHEMICAL INTERMEDIATES 2013
- 关键词：Concurrent synthesis Vanillin Isovanillin Vilsmeier-Haack reaction Selective dealkylation
- 质疑
- Tandem C-C/C-N Formation via Palladium-Catalyzed C-H Activation/Styrenation and Sequential Annulation of O-Methylketoxime with Styrenes被引量：42收藏
- 作者：Fu, Xiaopan Yang, Jinyue Deng, Kezuan Shao, Lingyan Xia, Chengcai Ji, Yafei
- 机构：East China Univ Sci & Technol;Shandong First Med Univ & Shandong Acad Med Sci
- 来源：ORGANIC LETTERS 2019
- 质疑
- A highly efficient approach to vanillin starting from 4-cresol被引量：41收藏
- 作者：Jiang, Jian-An Chen, Cheng Guo, Ying Liao, Dao-Hua Pan, Xian-Dao Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Chinese Acad Med Sci;Peking Union Med Coll
- 来源：GREEN CHEMISTRY 2014
- 质疑
- C-H Borylation of Diphenylamines through Adamantane-1-carbonyl Auxiliary by BBr3被引量：29收藏
- 作者：Wu, Gaorong Fu, Xiaopan Wang, Yangyang Deng, Kezuan Zhang, Lili Ma, Tao Ji, Yafei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Univ Chinese Med
- 来源：ORGANIC LETTERS 2020
- 质疑
- 'One-pot' synthesis of 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylates via lithium tert-butoxide-mediated sterically hindered Claisen condensation and Knorr reaction被引量：28收藏
- 作者：Jiang, Jian-An Huang, Wei-Bin Zhai, Jiao-Jiao Liu, Hong-Wei Cai, Qi Xu, Liu-Xin Wang, Wei Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Univ New Mexico
- 来源：TETRAHEDRON 2013
- 关键词：Lithium tert-butoxide Sterically hindered Claisen condensation 3-Substituted 4-aryl-2,4-diketoesters Knorr reaction 4-Substituted 1,5-diaryl-1H-pyrazole-3-carboxylates
- 质疑
- Practical Cu(OAc)2/TEMPO-catalyzed selective aerobic alcohol oxidation under ambient conditions in aqueous acetonitrile被引量：27收藏
- 作者：Jiang, Jian-An Du, Jia-Lei Wang, Zhan-Guo Zhang, Zhong-Nan Xu, Xi Zheng, Gan-Lin Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Roche R&D Ctr China Ltd
- 来源：TETRAHEDRON LETTERS 2014
- 关键词：Aerobic alcohol oxidation Ambient conditions Copper(II) acetate TEMPO Formation of carbonyl group
- 质疑
- ALTERNATE SYNTHESIS OF APIXABAN (BMS-562247), AN INHIBITOR OF BLOOD COAGULATION FACTOR XA被引量：26收藏
- 作者：Jiang, Jian'an Ji, Yafei
- 机构：E China Univ Sci & Technol
- 来源：SYNTHETIC COMMUNICATIONS 2013
- 关键词：Apixaban cost-effective synthetic route inhibitor of blood coagulation factor Xa 4-nitroaniline
- 质疑
- Metal-Free ortho-Selective C-H Borylation of 2-Phenylthiopyridines Using BBr3被引量：22收藏
- 作者：Wu, Gaorong Pang, Binghan Wang, Yangyang Yan, Li Chen, Lu Ma, Tao Ji, Yafei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Beijing Inst Technol;Beijing Univ Chinese Med
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2021
- 关键词：Reaction intermediates - Boron
- 质疑
- Ruthenium(II)-Catalyzed α-Fluoroalkenylation of Oxime Ethers with gem-Difluorostyrenes via C-H Activation and C-F Cleavage被引量：21收藏
- 作者：Zhang, Lili Deng, Kezuan Wu, Gaorong Yang, Jinyue Tang, Shibiao Fu, Xiaopan Xia, Chengcai Ji, Yafei
- 机构：East China Univ Sci & Technol;Shandong First Med Univ & Shandong Acad Med Sci
- 来源：JOURNAL OF ORGANIC CHEMISTRY 2020
- 关键词：Catalysis - Ketones - Reaction intermediates - Ruthenium compounds - Activation analysis - Ethers
- 质疑
- Adamantane-1-Carbonyl-Directed C-H Borylation and Hydroxylation of Benzenethiols被引量：21收藏
- 作者：Xu, Xiaobo Wu, Gaorong Yang, Zhaoziyuan Liu, Xian Hao, Liqiang Wang, Yangyang Ma, Zhihong Ji, Yafei
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol;Biotalk Co LTD
- 来源：ORGANIC LETTERS 2022
- 质疑
- Metal-Free Boron-Mediated ortho-C-H Hydroxylation of N-Benzyl-3,4,5-tribromopyrazoles被引量：19收藏
- 作者：Wu, Gaorong Yang, Zhaoziyuan Xu, Xiaobo Hao, Liqiang Chen, Lu Wang, Yangyang Ji, Yafei
- 机构：East China Univ Sci & Technol
- 来源：ORGANIC LETTERS 2022
- 质疑
- Efficient Co(OAc)2-catalyzed aerobic oxidation of EWG-substituted 4-cresols to access 4-hydroxybenzaldehydes被引量：18收藏
- 作者：Jiang, Jian-An Du, Jia-Lei Liao, Dao-Hua Wang, Zhan-Guo Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Roche R&D Ctr China Ltd
- 来源：TETRAHEDRON LETTERS 2014
- 关键词：Aerobic oxidation 4-Cresols 4-Hydroxybenzaldehydes Co(OAc)(2) Ethylene glycol
- 质疑
- Cascade Reaction for the Synthesis of Carbolines from O-Methylketoximes and Styrenes via Palladium-Catalyzed C-H Activation and Sequential Annulation被引量：18收藏
- 作者：Fu, Xiao-Pan Tang, Shi-Biao Yang, Jin-Yue Zhang, Li-Li Xia, Cheng-Cai Ji, Ya-Fei
- 机构：East China Univ Sci & Technol;Shandong First Med Univ & Shandong Acad Med Sci
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2019
- 关键词：Carbolines Dual C-C C-N formation Annulation Styrenes Palladium
- 质疑
- Palladium-Catalyzed Divergent Regioselective Homocoupling and Hydroxylation of 3-Arylbenzo[d]isoxazoles被引量：18收藏
- 作者：Guo, Ying Yu, Kun-Kun Xing, Li-Hao Liu, Hong-Wei Wang, Wei Ji, Ya-Fei
- 机构：East China Univ Sci & Technol;Univ New Mexico
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2017
- 关键词：benzoisoxazoles C-H bond activation divergent synthesis homocoupling hydroxylation
- 质疑
- 制药工程专业学生创新能力培养的探索与实践被引量：17收藏
- 作者：虞心红 宋恭华 卓超 马红梅 施小新 冀亚飞 侯志安 沈永嘉
- 机构：华东理工大学药学院
- 来源：《化工高等教育》 2008
- 关键词：制药工程专业 创新 人才培养体系 探索 实践
- 摘要：如何培养工科专业学生的创新能力,是富有挑战性的研究课题。制药工程专业是一个隶属于化工与制药类的工科专业。本着知识、素质和能力协调发展的培养原则,本文对制药工程专业的创新人才培养体系和人才培养模式进行了认真的探索和实践分析...
- 下载全文在线阅读质疑
- One-Pot Synthesis of 4-Substituted 1,5-Diaryl-1H-pyrazole-3-carboxylic Acids via a MeONa/LiCl-Mediated Sterically Hindered Claisen Condensation-Knorr Reaction-Hydrolysis Sequence被引量：17收藏
- 作者：Jiang, Jian-An Du, Cai-Yan Gu, Chun-Hui Ji, Ya-Fei
- 机构：E China Univ Sci & Technol
- 来源：SYNLETT 2012
- 关键词：MeONa/LiCl sterically hindered Claisen condensation Knorr reaction 4-substituted 1,5-diaryl-1H-pyrazole-3-carboxylic acids "one-pot" synthesis
- 质疑
- Pd-catalyzed direct oxidative mono-aroyloxylation of O-aralkyl substituted acetoxime ethers被引量：16收藏
- 作者：Shao, Ling-Yan Li, Chao Guo, Ying Yu, Kun-Kun Zhao, Fei-Yi Qiao, Wen-Li Liu, Hong-Wei Liao, Dao-Hua Ji, Ya-Fei
- 机构：East China Univ Sci & Technol;Roche R&D Ctr China Ltd
- 来源：RSC ADVANCES 2016
- 关键词：Aromatic compounds - Catalysis - Organometallics
- 质疑
- 深化实践教学改革 提高生产实习教学质量被引量：16收藏
- 作者：马红梅 侯志安 刘宏伟 段梅莉 冀亚飞 卓超 虞心红 施小新
- 机构：华东理工大学药学院
- 来源：《化工高等教育》 2010
- 关键词：校外实习 师资建设 创新教育 主动学习 教学改革
- 摘要：校外生产实习是工科专业大学生在大学学习过程中必不可少的一个重要环节,对工科专业的人才培养质量有着非常重要的影响。本文针对华东理工大学制药工程专业校外实习现状,介绍了近年来该专业在校外实习基地建设、校外实习师资队伍建设、生...
- 下载全文在线阅读质疑
- 氯虫酰胺的合成被引量：16收藏
- 作者：陈一芬 刘爱霞 冀亚飞
- 机构：华东理工大学药学院
- 来源：《化学试剂》 2010
- 关键词：氯虫酰胺 杀虫剂 鱼尼丁受体 合成
- 摘要：以3-甲基-2-硝基苯甲酸为原料,经酯化、还原、氯化、氨解制得关键中间体2-氨基-5-氯-N,3-二甲基苯甲酰胺。中间体与3-溴-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酸发生酰胺化反应制得标题化合物,总收率55....
- 下载全文在线阅读质疑
- Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides被引量：15收藏
- 作者：Guo, Ying Fan, Xue-Min Nie, Min Liu, Hong-Wei Liao, Dao-Hua Pan, Xian-Dao Ji, Ya-Fei
- 机构：E China Univ Sci & Technol;Chinese Acad Med Sci;Peking Union Med Coll
- 来源：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY 2015
- 关键词：Homogeneous catalysis Copper Alkoxylation Aromatic substitution
- 质疑
- Azobenzene-isoxazoline as photopharmacological ligand for optical control of insect GABA receptor and behavior被引量：15收藏
- 作者：Qiao, Zhi Ji, Yunfan Zhang, Yongchao Li, Zhong Xu, Zhiping Shao, Xusheng
- 机构：East China Univ Sci & Technol;East China Univ Sci & Technol
- 来源：PEST MANAGEMENT SCIENCE 2022
- 关键词：photopharmacology photochromic GABARs isoxazoline invertebrates
- 质疑
- Pd-Catalyzed Late-Stage Monoacetoxylation and Monoiodination of 4-Alkyl-1,5-diaryl-1H-pyrazole-3-carboxylates via Direct Csp2-H Bond Activation被引量：15收藏
- 作者：Fan, Xue-Min Guo, Ying Li, Yu-Dan Yu, Kun-Kun Liu, Hong-Wei Liao, Dao-Hua Ji, Ya-Fei
- 机构：E China Univ Sci & Technol
- 来源：ASIAN JOURNAL OF ORGANIC CHEMISTRY 2016
- 关键词：acetoxylation C-H activation iodination palladium pyrazoles
- 质疑
- 达格列净的合成被引量：15收藏
- 作者：禹艳坤 冀亚飞
- 机构：华东理工大学药学院
- 来源：《中国医药工业杂志》 2011
- 关键词：达格列净 降糖药 合成
- 摘要：5-溴-2-氯苯甲酸经酰氯化、与苯乙醚发生付-克反应、还原羰基得5-溴-2-氯-4'-乙氧基二苯甲烷,再与2,3,4,6-四-O-三甲基硅-D-吡喃葡萄糖酸-1,5-内酯(3)缩合、异头碳羟基醚化、脱保护得2-氯-5-(...
- 下载全文在线阅读质疑
- 对甲苯磺酸索拉非尼的合成被引量：15收藏
- 作者：赵乘有 陈林捷 许煦 罗晓燕 冀亚飞
- 机构：华东理工大学药学院;华东理工大学化工学院
- 来源：《中国医药工业杂志》 2007
- 关键词：索拉非尼 抗肿瘤药 多激酶抑制剂 合成
- 摘要：吡啶甲酸经氯化、酰胺化、亲核取代得中间体4-(4-氨基苯氧基)-2-(甲基氨甲酰基)吡啶,与4-氯-3-(三氟甲基)苯异氰酸酯缩合、再成盐得对甲苯磺酸索拉非尼,总收率为64%。
- 下载全文在线阅读质疑
- Electrochemically Induced Desulfurization of Thioureas for the Synthesis of Substituted 5-Aminotetrazoles被引量：15收藏
- 作者：Yu, Xiao Hao, Liqiang Liu, Xian Jin, Shengkui Liu, Yiping Ji, Yafei
- 机构：Minist Educ;East China Univ Sci & Technol;Chongqing Med & Pharmaceut Coll
- 来源：ADVANCED SYNTHESIS & CATALYSIS 2024
- 关键词：Addition-cyclization Desulfurization Electrosynthesis Substituted 5-aminotetrazoles
- 质疑
